Anti-α-glucosidase and anti-oxidative isoflavonoids from the immature fruits of Maclura tricuspidata

Jo, Yang Hee; Lee, Solip; Yeon, Sang Won; Ryu, Se Hwan; Turk, Ayman; Hwang, Bang Yeon; Han, Yoo Kyong; Lee, Ki Yong; Lee, Mi Kyeong

doi:10.1016/j.phytochem.2021.113016

Cited by 9 publications

(6 citation statements)

References 36 publications

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“…The techniques of molecular docking, ultraviolet absorption, and fluorescence quenching tests have demonstrated that the bee bread contains functional fatty acids thatinteract with the amino acid residues of hydrolyzing enzymes through hydrogens bonds and vander Waals interactions [ 70 ]. Bee bread is a complex product with a high flavonoid content; flavonoids are known for their capacity to embed in the active site of the enzyme by bond and alkyl interactions, which are facilitated through the diverse methyl and hydroxyl groups that characterize the flavonoid’s structure [ 71 ]. The ability of bee bread to control metabolism disorders through the inhibition of carbohydrate-hydrolyzing enzymes has been confirmed by in vivo studies detailing the pharmacological effects of bee bread, as shown in the in vivo investigations section ( Table 2 ).…”

Section: The Bioactive Effect Of Bee Bread: In Vitro Investigationsmentioning

confidence: 99%

Bee Bread as a Promising Source of Bioactive Molecules and Functional Properties: An Up-To-Date Review

et al. 2022

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Bee bread is a natural product obtained from the fermentation of bee pollen mixed with bee saliva and flower nectar inside the honeycomb cells of a hive. Bee bread is considered a functional product, having several nutritional virtues and various bioactive molecules with curative or preventive effects. This paper aims to review current knowledge regarding the chemical composition and medicinal properties of bee bread, evaluated in vitro and in vivo, and to highlight the benefits of the diet supplementation of bee bread for human health. Bee bread extracts (distilled water, ethanol, methanol, diethyl ether, and ethyl acetate) have been proven to have antioxidant, antifungal, antibacterial, and antitumoral activities, and they can also inhibit α-amylase and angiotensin I-converting enzyme in vitro. More than 300 compounds have been identified in bee bread from different countries around the world, such as free amino acids, sugars, fatty acids, minerals, organic acids, polyphenols, and vitamins. In vivo studies have revealed the efficiency of bee bread in relieving several pathological cases, such as hyperglycemia, hyperlipidemia, inflammation, and oxidative stress.

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Section: The Bioactive Effect Of Bee Bread: In Vitro Investigationsmentioning

confidence: 99%

Bee Bread as a Promising Source of Bioactive Molecules and Functional Properties: An Up-To-Date Review

et al. 2022

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“…The description of the α-amylase and α-glucosidase inhibitory capacity of the extracts from M. pomifera bark and periderm represents a novel and original aspect of the present study. The current literature provides information on a moderate potential for αglucosidase inhibition in extracts obtained through maceration in ethyl acetate from M. fruticosa branches, as well as the efficiency of the flavonoid fraction isolated from immature fruits of M. tricuspida in inhibiting the activity of this enzyme (Polbuppha et al 2017;Jo et al 2022). Another study demonstrated that pomiferin significantly stimulated blood insulin levels while simultaneously reducing serum glucose and triglyceride levels in normal rats over a 14-day period following administration of doses at 100 and 300 mg/kg.…”

Section: Discussionmentioning

confidence: 99%

Comparative study on the chemical composition and biological activity of polyphenolic extracts obtained from Maclura pomifera (Raf.) C.K. Schneid bark and periderm

Coman,

Babotă,

Nădășan

et al. 2023

BioRes

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Literature is limited regarding the potential use of the bark of Maclura pomifera as a source of bioactive compounds. The influence of different extraction methods was assessed for the chemical and biological properties of extracts obtained from the bark and periderm of M. pomifera. The extraction process was completed using three methods: microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE), and sonicator-assisted extraction (SAE). The extracts were characterized by total polyphenol content. The antioxidant capacity was evaluated using DPPH and ABTS methods, the antimicrobial effect was tested against Gram-positive and Gram-negative bacterial strains, and the inhibition of enzyme activity was conducted using α-glucosidase, lipase, and α-amylase assays. The extracts obtained from the periderm exhibited a lower total polyphenolic content compared to those obtained from the bark. The highest antioxidant activity using the DPPH method was observed in the MAE bark extracts and when using the ABTS method, and the highest activity was observed in the UAE bark extracts. Enzymatic activity was most strongly inhibited by the SAE bark extract. The most pronounced antibacterial potential was observed in the MAE and UAE bark extracts, with minimum inhibitory concentration values obtained below 1 mg/mL.

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“…Daidzein and genistein are commonly known as phytoestrogens because of their oestrogenic activity in various models of animals. Tey have antidiabetic, antioxidant, and also effective against Leishmania infantum, cytotoxicity against Hep G2 cell lines, and Leishmania amazonensis [24,25]. Isofavonoids are essential for preventing cataract development in diabetic and hypertensive animal models [26].…”

Section: Flavonolsmentioning

confidence: 99%

A Comprehensive Review of the Pharmacological Importance of Dietary Flavonoids as Hepatoprotective Agents

Gajender

Mazumder

Sharma

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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The liver is a crucial organ that is involved in various kinds of metabolic activity and a very stable accessory gland for the digestive system. Long-term or persistent inflammation and oxidative stress due to any reasons have a substantial impact on the beginning and continuation of chronic diseases such as hepatocellular carcinoma, liver cirrhosis, liver fibrosis, and other hepatic conditions. There are many sources which can help the liver to be healthy and enhance its metabolic potential of the liver. Since the diet is rich origin of bioactive along with antioxidant chemicals including flavonoids and polyphenols, it can control different stages of inflammation and hepatic diseases. Numerous food sources, notably vegetables, nuts, fruits, cereals, beverages, and herbal medicinal plants, are rich in bioactive chemicals called flavonoids and their derivatives like Flavones, Anthocyanins, Iso-flavonoid, Flavanones, Flavanols, and Flavan-3-ols. Most recently occurred research on flavonoids has demonstrated that they can regulate hepatoprotective properties. This is because they are essential parts of pharmaceutical and nutraceutical products due to their hepatoprotective, antioxidative, and immune-modulating characteristics. However, the characteristics of their hepatoprotective impact remain unclear. The purpose of this comprehensive review is to survey the flavonoid structure and enriched sources for their hepatoprotective and antioxidant effects concerning liver toxicity or injury.

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Anti-α-glucosidase and anti-oxidative isoflavonoids from the immature fruits of Maclura tricuspidata

Cited by 9 publications

References 36 publications

Bee Bread as a Promising Source of Bioactive Molecules and Functional Properties: An Up-To-Date Review

Bee Bread as a Promising Source of Bioactive Molecules and Functional Properties: An Up-To-Date Review

Comparative study on the chemical composition and biological activity of polyphenolic extracts obtained from Maclura pomifera (Raf.) C.K. Schneid bark and periderm

A Comprehensive Review of the Pharmacological Importance of Dietary Flavonoids as Hepatoprotective Agents

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