Anti-ZnT8 autoantibodies: A new marker to be screened in patients with anti-adrenal antibodies

Bost, Chloé; Jordan, Teoli; Dechomet, Magali; Fortenfant, Françoise; Nicole, Fabien

doi:10.1016/j.cca.2020.09.019

Cited by 1 publication

(1 citation statement)

References 33 publications

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“…Elucidating the functional impact of the different ZnT8 protein variants is essential for understanding how they affect diabetes [312][313][314][315]. New specific antibodies are also required for immunodetection of these variants [316][317][318][319][320]. In addition, more functional studies of the variants are needed to develop specific strategies to counteract their contribution to diabetes pathology [321].…”

Section: Znt8 (Slc30a8)mentioning

confidence: 99%

Impact of Zinc Transport Mechanisms on Embryonic and Brain Development

Willekens

Runnels

2022

Nutrients

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The trace element zinc (Zn) binds to over ten percent of proteins in eukaryotic cells. Zn flexible chemistry allows it to regulate the activity of hundreds of enzymes and influence scores of metabolic processes in cells throughout the body. Deficiency of Zn in humans has a profound effect on development and in adults later in life, particularly in the brain, where Zn deficiency is linked to several neurological disorders. In this review, we will summarize the importance of Zn during development through a description of the outcomes of both genetic and early dietary Zn deficiency, focusing on the pathological consequences on the whole body and brain. The epidemiology and the symptomology of Zn deficiency in humans will be described, including the most studied inherited Zn deficiency disease, Acrodermatitis enteropathica. In addition, we will give an overview of the different forms and animal models of Zn deficiency, as well as the 24 Zn transporters, distributed into two families: the ZIPs and the ZnTs, which control the balance of Zn throughout the body. Lastly, we will describe the TRPM7 ion channel, which was recently shown to contribute to intestinal Zn absorption and has its own significant impact on early embryonic development.

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