Anti-viral triterpenes: a review

Darshani, Priya; Sarma, Shreya Sen; Srivastava, Amit Kumar; Baishya, Rinku; Kumar, Deepak

doi:10.1007/s11101-022-09808-1

Cited by 32 publications

(20 citation statements)

References 206 publications

(263 reference statements)

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“…From this extract, five cycloartane triterpenoids (1-5), two sterols (6, 7) and two aliphatic compounds (8,9) were isolated, of which compounds 2-5, 8, 9 have been identified for the first time from C. papaya. Cycloartane triterpenoids, the class of compounds which have been reported to possess antiviral properties, [22] were found as the main constituents of the active antidengue n-hexane extract of C. papaya leaves. Further study on antidengue virus activity of the above isolated compounds are being proceeded in our group to investigate potential inhibitors from Papaya leaf extract against dengue fever.…”

Section: Structural Elucidation Of the Compounds Isolated From The Ac...mentioning

confidence: 99%

Phytochemistry of the unpolar extract of Carica papaya leaves and its antidengue activity

Thao,

Dung,

Ninh

et al. 2022

Vietnam Journal of Chemistry

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Antidenge activity of the n‐hexane, ethyl acetate and n‐butanol extracts from the leaves of Carica papaya against four dengue virus serotypes (DENV1‐4) were evaluated. As a result, the n‐hexane extract showed the best antiviral activity on all denge virus with PNRT50 from 15.625 to 31.25 μg/ml. From n‐hexane extract, nine compounds including cycloartenol (1), cycloart‐23,25‐dien‐3β‐ol (2), cycloart‐25‐ene‐3β,24β‐diol (3), cycloart‐25‐ene‐3β,24α‐diol (4), 25‐hydroxycycloart‐23‐ene‐3‐one (5), β‐sitosterol (6), stigmasterol (7), nonacosan‐1‐ol (8), all‐trans‐polyprenol‐12 (9) were isolated. Structural elucidation of the above compounds was supported by analysis of their spectral data. Compounds 2‐5, 8 and 9 were isolated for the first time from the plant Carica papaya.

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Section: Structural Elucidation Of the Compounds Isolated From The Ac...mentioning

confidence: 99%

Phytochemistry of the unpolar extract of Carica papaya leaves and its antidengue activity

Thao,

Dung,

Ninh

et al. 2022

Vietnam Journal of Chemistry

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“…As a result, the current review deals with all available plant-derived antiviral metabolites which are available as an alternative approach against COVID-19. In order to create targeted treatments for newly found diseases, researchers must first understand the structure, life cycle, pathogenicity, cell signaling, epidemiology, pharmaceutical targets, and drug discovery process of these viruses [ 45 - 46 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Plant Metabolites on the Growth of COVID-19 (Coronavirus Disease-19) Including Omicron Strain

Bagde¹,

Dhopte²

2022

Cureus

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According to recent reports out of India, a new strain of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) B1.1.529 Omicron virus has emerged. In comparison to the Wuhan (WHU) strain and the delta variant, this variant showed a far stronger effect on the angiotensin converting enzyme2 (ACE2) receptor. There are several medicinal compounds in plant metabolites, and their diverse chemical structures make them ideal for the treatment of serious illnesses. It's possible that some of these could be useful alternative pharmaceuticals, as well as a starting point for the repurposing of existing medications and new chemical discoveries. SARS-CoV-2 infection triggered a worldwide epidemic of the severe acute respiratory syndrome (SARS). There have been trials for different therapies for SARS-CoV-2 and so also there are recent announcements of extensive research into the development of viable medicines for this global health calamity. After a thorough examination of plant-derived treatments for COVID-19, investigators in the current study decided to focus on plant-derived secondary metabolites (PSMs). According to some researchers, new MDR (Multi-Drug Resistant) antibiotics may one day be developed due to the adaptability of secondary metabolites. Identifying plant metabolites that can treat a wide range of viral infections was one of the study's aims. Many natural medications that could be recommended for the treatment of COVID-19 were discovered as a result of this research, including remedies from plant families, viral candidates that are susceptible, antiviral assays, and mechanisms of therapeutic action. The findings of this study will inspire further research and speed up the development of new antiviral plant-based medications.

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“…Triterpenes are secondary metabolites and have received close attention because they are known to have anti-inflammatory [ 8 ], antioxidant [ 9 , 10 ], antiviral [ 11 ], antibacterial [ 12 , 13 ], antifungal [ 14 ] and antineoplastic activities [ 9 ], among others. Their antineoplastic activities are of particular interest in cancer research.…”

Section: Introductionmentioning

confidence: 99%

Lupane Triterpene Derivatives Improve Antiproliferative Effect on Leukemia Cells through Apoptosis Induction

et al. 2022

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Leukemia is one of the most frequent types of cancer. No effective treatment currently exists, driving a search for new compounds. Simple structural modifications were made to novel triterpenes isolated from Phoradendron wattii. Of the three resulting derivatives, 3α-methoxy-24-hydroxylup-20(29)-en-28-oic acid (T1m) caused a decrease in the median inhibitory concentration (IC50) on the K562 cell line. Its mode of action was apparently apoptosis, ROS generation, and loss of mitochondrial membrane potential (MMP). Molecular docking analysis showed T1m to produce lower binding energies than its precursor for the Bcl-2 and EGFR proteins. Small, simple, and viable modifications to triterpenes can improve their activity against leukemia cell lines. T1m is a potentially promising element for future research. Clarifying the targets in its mode of action will improve its applicability.

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Anti-viral triterpenes: a review

Cited by 32 publications

References 206 publications

Phytochemistry of the unpolar extract of Carica papaya leaves and its antidengue activity

Phytochemistry of the unpolar extract of Carica papaya leaves and its antidengue activity

Effects of Plant Metabolites on the Growth of COVID-19 (Coronavirus Disease-19) Including Omicron Strain

Lupane Triterpene Derivatives Improve Antiproliferative Effect on Leukemia Cells through Apoptosis Induction

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