Anti-VHE IgM en casos de infección por el virus hepatitis E

Abstract

Background: Hepatitis E virus is the main enterically transmitted non A non B hepatitis agent. The host IgM response in the acute hepatitis virus E, without evidence of infection with hepatitis A, B or C virus. Measurement of the same antibodies in 25 additional samples positive for IgM antibodies against hepatitis A virus but without study for hepatitis virus B or C. Results: IgM antibodies against virus E were detected in 12 of the 35 samples positive for IgG antibodies (34%) and in five of the 25 samples positive for antibodies against virus A (20%). Conclusions: An acute hepatitis E virus infection was detected in 34% of samples positive for IgG antibodies against this virus. The absence of IgM antibodies in the rest of the IgG positive samples could be due to an old or a recent virus E infection in the stage of antibody titer reduction. The detection of IgM antibodies against virus E in samples positive for virus A antibodies, could be due to co infection by virus A and E or a cross reaction of assays (Rev Méd Chile 2005; 133: 645-7).

Seroprevalence of hepatitis E virus infection in the Americas: Estimates from a systematic review and meta-analysis

“…In 12 studies reporting IgM results from sera of patients with confirmed or suspected acute viral hepatitis (viral hepatitis group), the seroprevalence ranged from 0% to 100%, with a median of 8%. Seroprevalences higher than 10% were reported from Venezuela [ 39 ], Chile [ 40 ], Colombia [ 41 ], and Cuba [ 42 – 44 ], the latter country accounted also for the observed prevalence of 100% [ 44 ] (Fig 16, page 75 in S1 File ). Without this apparent HEV outbreak, the pooled seroprevalence was 5.5% (95% CI: 2.0%– 14.1%, I 2 = 93%, tau 2 = 2.1), significantly (Q-test, p = 0.006) higher than in the other subgroups (pooled together).…”

Infección por el virus de la hepatitis E en pacientes con diagnóstico clínico de hepatitis viral en Colombia

“…La presencia del marcador IgM anti-HEV se buscó en muestras de casos esporádicos de hepatitis no A, no B, no C de diferentes regiones de Cuba; los autores describieron una seropositividad de 33,3 % (13/39) (57). Por su parte, Hurtado, et al, analizaron 78 muestras de casos con diagnóstico presuntivo de hepatitis viral remitidas al Hospital Clínico Universidad de Chile, 66 % (35/53) de las cuales fueron positivas para el marcador IgG anti-HEV y, de estas, 34 % (12/35) presentaron, además, el marcador IgM anti-HEV (58). En un estudio en Venezuela, los autores demostraron la presencia de IgM anti-HEV en 29,7 % (22/74) de las muestras provenientes de pacientes con diagnóstico clínico de hepatitis viral aguda (59).…”

Cambios en la epidemiología de las hepatitis virales en Chile y consideraciones en estrategias de prevención

“…Es difícil obtener información sobre la incidencia de hepatitis aguda por virus E en Chile. Hay comunicaciones de casos aislados, en donde se ha utilizado anti-VHE IgG y anti-VHE IgM 49,50 . Debería investigarse cuando todos los marcadores para los virus de hepatitis A, B y C sean negativos.…”