Anti-vasospastic Effects of Epidermal Growth Factor Receptor Inhibitors After Subarachnoid Hemorrhage in Mice

Nakano, Fumi; Kawakita, Fumihiro; Liu, Lei; Nakatsuka, Yoshinari; Nishikawa, Hirofumi; Okada, Takeshi; Kanamaru, Hideki; Pak, Sujon; Shiba, Masato; Suzuki, Hiroyoshi

doi:10.1007/s12035-018-1400-6

Cited by 17 publications

(19 citation statements)

References 39 publications

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“…Delayed cerebral ischemia may be caused by cerebral vasospasm, cortical spreading depolarization, and microcirculatory dysfunction [12], which may occur secondary to EBI [13]. Although cerebral vasospasm remains an important cause of delayed cerebral ischemia [14], microcirculatory disturbance and cortical spreading depolarization may be more important than cerebral vasospasm as to the impact on functional outcomes especially in poor-grade SAH patients [15]. Thus, many basic researchers have worked hard to overcome EBI, which is believed eventually to improve outcomes of poor-grade SAH patients.…”

mentioning

confidence: 99%

Inflammation: a Good Research Target to Improve Outcomes of Poor-Grade Subarachnoid Hemorrhage

Suzuki

2019

Transl. Stroke Res.

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confidence: 99%

Inflammation: a Good Research Target to Improve Outcomes of Poor-Grade Subarachnoid Hemorrhage

Suzuki

2019

Transl. Stroke Res.

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“…Approximately 10% to 16% of patients die before hospital admission, and around 25% patients remain dependent on assistance [8]. Clinical symptoms of SAH include varying degrees of neurological disorders, from headache and aphasia to hemiplegia or coma [3,4]. The most common clinical symptom in our study was headaches ( Table 2).…”

Section: Discussionmentioning

confidence: 78%

“…Despite improvements in diagnostic and therapeutic techniques, SAH has a high morbidity and mortality rate. Moreover, only 25% of patients are able to live without assistance [1,3,4].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the platelet volume index as a prognostic factor after aneurysmal subarachnoid hemorrhage

Dündar¹,

Kitiş²,

Abdallah³

et al. 2019

Journal of Surgery and Medicine

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Aim: Subarachnoid Hemorrhage (SAH) originating from an intracranial aneurysm is a severe and life-threatening disease, witnessed by physicians in Emergency Departments (ED). Despite the improvements in diagnostic and therapeutic techniques, morbidity and mortality rates of SAH remain high. Several parameters based on biochemical analysis and imaging techniques are used to evaluate the prognosis. However, efforts for identifying an ideal marker have not been successful. For many years, Fisher Grading System, which is based on computerized tomography (CT), has been used as a reliable predictive scale to identify SAH. Besides, the immune response plays an active role in determining neuro-damage after SAH. Recently, Mean platelet volume (MPV) to platelet count (PLT) ratio has become a trend indicator to anticipate the outcome of a patient suffering from SAH. This study aims to determine whether the comparison of the immune response marker [Platelet Volume Index (PVI)] with the Fisher Grading System could be used as a prognostic factor in subarachnoid hemorrhages with ruptured intracranial aneurysms. Methods: In this retrospective cohort study, 52 patients diagnosed with spontaneous SAH in the ED were included. The patients' ages, genders, Fisher grades, locations of the ruptured aneurysm, PVI and Glasgow Coma Scale (GCS) scores were recorded. MPV:PLT ratio was defined as MPV value(fL) x100 /PLT (per 1000). Each patient's GCS at the time of their admission to the ED was noted. An experienced radiologist graded their initial CT scans immediately according to the Fisher Grading System. Patients' GCS scores were noted by the investigators and PVI was calculated. A retrospective review was carried out regarding medical records of age, sex, and other conditions. The Pearson Correlation Coefficient was used in the analysis of the interrelationship. Results: The correlation among the PVI with GCS and Fisher Grade test was found to be positive statistically correlation. Relevant literature establishes the same result. Additionally, analyses established a significant positive correlation between the Fisher Grading Scale and the PVI among the data of ruptured aneurysms. Conclusion: The PVI can be used as a prognostic, predictive factor for SAH. Nevertheless, further studies concerning the prognosis of SAH are needed to confirm this hypothesis.

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“…VEGF receptor2 (VEGFR-2), which is a major receptor of VEGF, was reported to be activated after experimental SAH and, VEGFR2 blockage suppresses post-SAH bloodbrain barrier (BBB) damage [12]. VEGFR involvement in the pathophysiology of SAH in cerebral arteries was also reported [13]. To our best knowledge there is no previous study evaluating the impact of anti_VEGF treatment effects after SAH.…”

Section: Discussionmentioning

confidence: 99%

What is the restorative effect of VEGF inhibitor bevacuzimab against subarachnoid hemorrhage in an experimental model?

DEMİRCİ,

GÜVENÇ,

ÖZEREN

et al. 2021

Turk J Med Sci

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Anti-vasospastic Effects of Epidermal Growth Factor Receptor Inhibitors After Subarachnoid Hemorrhage in Mice

Cited by 17 publications

References 39 publications

Inflammation: a Good Research Target to Improve Outcomes of Poor-Grade Subarachnoid Hemorrhage

Inflammation: a Good Research Target to Improve Outcomes of Poor-Grade Subarachnoid Hemorrhage

Evaluation of the platelet volume index as a prognostic factor after aneurysmal subarachnoid hemorrhage

What is the restorative effect of VEGF inhibitor bevacuzimab against subarachnoid hemorrhage in an experimental model?

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