Anti-urolithiatic and anti-inflammatory activities through a different mechanism of actions of Cissus gongylodes corroborated its ethnopharmacological historic

Salem, Paula P.O.; Vieira, Nátalie B.; Garcia, Daniela A.; Nicácio, Karen J.; Dias, Danielle Ferreira; Paula, Alessandro Vinícius de; Assis, Diego M.; Caldas, Ivo Santana; Novaes, Rômulo Dias; Marinho, Maria Vanda; Rosa, Iara M. L.; Soares, Marisi G.; Chagas‐Paula, Daniela Aparecida

doi:10.1016/j.jep.2020.112655

Cited by 5 publications

(6 citation statements)

References 60 publications

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“…Considering the ethnopharmacological data indicating the traditional utilization of E. arborea against kidney stones, there has been no scientific documentation established on the antiurolithic activity of leaves and flower extracts of E. arborea . Nephrolithiasis is a very common urologic disorder consisting of the appearance of kidney stones ( Salem et al, 2020 ), due to many stages through supersaturation, aggregation, crystal nucleation, and growth of different mineral elements in the urine. Kidney stones consist of CaOx, which accounts for about 80% of patients ( Mammate et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…However, the elevated price and the side effects of traditional treatments make it less focused by the public ( Ly et al, 2021 ). In this context, the wide use of medicinal plants in the therapy of kidney stones and the development of anti-urolithiasis drugs, with minimal side effects and largely expanded in the world, could decrease urolithiasis diseases ( Salem et al, 2020 , Kumar et al, 2021 ). The curative effect and efficiency of medicinal plants in anti-crystallization properties may be associated with several chemical phytoconstituents, which can act as inhibitors ( Salem et al, 2020 , Mammate et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…In this context, the wide use of medicinal plants in the therapy of kidney stones and the development of anti-urolithiasis drugs, with minimal side effects and largely expanded in the world, could decrease urolithiasis diseases ( Salem et al, 2020 , Kumar et al, 2021 ). The curative effect and efficiency of medicinal plants in anti-crystallization properties may be associated with several chemical phytoconstituents, which can act as inhibitors ( Salem et al, 2020 , Mammate et al, 2022 ). It is largely indicated that flavonoids, tannins, coumarins, and terpenoids isolated from different anti-urolithiasis plants can lead to diuretic and anti-urolithiasis effects ( Ahmed et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

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Anti-urolithiatic, antibacterial, anti-inflammatory and analgesic effects of Erica arborea flowers and leaves hydromethanolic extracts: An ethnopharmacological study

Amari,

Karbab,

Charef

et al. 2023

Saudi Journal of Biological Sciences

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Anti-urolithiatic, antibacterial, anti-inflammatory and analgesic effects of Erica arborea flowers and leaves hydromethanolic extracts: An ethnopharmacological study

Amari,

Karbab,

Charef

et al. 2023

Saudi Journal of Biological Sciences

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“…The first scan event was a full-scan mass spectrum. The second scan event was an MS/MS experiment carried out by using a data-dependent analysis (Salem et al 2020) and the collision-induced dissociation (CID) with CE=30eV.…”

Section: Chromatographic Methods and Chemical Annotationmentioning

confidence: 99%

Chemical annotation of the infusion of Jungia floribunda Less and its inhibitory potential on the elastase enzyme

Ribeiro,

Santos,

Salem

et al. 2023

Natural Product Research

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Jungia floribunda Less. is a shrub belonging to the Asteraceae. The infusion of its leaves has been used, in folk medicine of several South American countries, as anti-inflammatory and hypoglycemic agent. In the present study, the infusion of leaves from J. floribunda was obtained and its chemical composition was determined by UHPLC-MS associated with molecular network allowing the annotation of flavonoids, sesquiterpene lactones, coumarins, and chlorogenic acid derivatives. Besides, in vitro elastase activity assay was carried out with the infusion. As observed, elastase was inhibited at concentrations ranging from 15 to 240 µg/mL, reaching to 71% of inhibition at the maximum of evaluated concentration. Given that species of plants are promising sources for the discovery of new drugs, these results corroborate the infusion of J. floribunda as a potential source of bioactive compounds for the discovery of new inhibitors for elastase, besides its ethnopharmacological aspects.

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“…Nonetheless, herbal medicine is attractive for various metabolic diseases, including obesity, owing to its broad range of safety margins. Cissus spp., belonging to the family Vitaceae, consists of approximately 80 species [19] and has been used to treat diabetes, inflammation, epilepsy, and pain in traditional medicine [20][21][22][23][24]. Among Cissus spp., Cissus verticillata (also called Cissus sicyoides) and Cissus quadrangularis are the most popular; they decrease fat accumulation and weight gain [25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Extracts from the Leaves of Cissus verticillata Ameliorate High-Fat Diet-Induced Memory Deficits in Mice

Kim

Kwon

Jung

et al. 2021

Plants

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We investigated the effects of Cissus verticillata leaf extract (CVE) on a high-fat diet (HFD)-induced obesity and memory deficits. Male mice (5 weeks of age) were fed vehicle (distilled water), or 30, 100, or 300 mg/kg of CVE once a day for 8 weeks with an HFD. Treatment with CVE resulted in lower body weight and glucose levels in a concentration- and feeding time-dependent manner. LDL cholesterol and triglyceride levels were significantly lower in the CVE-treated HFD group than in the vehicle-treated HFD group. In contrast, high-density lipoprotein cholesterol levels did not show any significant changes. Lipid droplets and ballooning were reduced depending on the concentration of CVE treatment compared to the HFD group. Treatment with CVE ameliorated the increase in glucagon and immunoreactivities in the pancreas, and novel object recognition memory was improved by 300 mg/kg CVE treatment compared to the HFD group. More proliferating cells and differentiated neuroblasts were higher in mice treated with CVE than in vehicle-treated HFD-fed mice. Brain-derived neurotrophic factor (BDNF) levels were significantly decreased in the HFD group, which was facilitated by treatment with 300 mg/kg CVE in hippocampal homogenates. These results suggest that CVE ameliorates HFD-induced obesity and memory deficits in mice, associated with increased BDNF levels in the hippocampus.

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Anti-urolithiatic and anti-inflammatory activities through a different mechanism of actions of Cissus gongylodes corroborated its ethnopharmacological historic

Cited by 5 publications

References 60 publications

Anti-urolithiatic, antibacterial, anti-inflammatory and analgesic effects of Erica arborea flowers and leaves hydromethanolic extracts: An ethnopharmacological study

Anti-urolithiatic, antibacterial, anti-inflammatory and analgesic effects of Erica arborea flowers and leaves hydromethanolic extracts: An ethnopharmacological study

Chemical annotation of the infusion of Jungia floribunda Less and its inhibitory potential on the elastase enzyme

Extracts from the Leaves of Cissus verticillata Ameliorate High-Fat Diet-Induced Memory Deficits in Mice

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