Anti-ulcerogenic activity of some plants used as folk remedy in Turkey

Gürbüz, İlhan; Üstün, Osman; Yeşilada, Erdem; Sezik, Ekrem; Kutsal, Osman

doi:10.1016/s0378-8741(03)00174-0

Cited by 136 publications

(79 citation statements)

References 4 publications

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“…However, the anti-ulcerogenic effect was not statistically significant. This finding also differs from earlier reports by Deliorman Orhan et al 2 and Gürbüz et al 7 who found up to 100% ulcerogenic protection by R. canina extracts made from whole fruits containing a combination of seeds and shells.…”

Section: Studies In Ratscontrasting

confidence: 99%

“…Interestingly, extractions of whole rose hip or fruits of R. canina have earlier been indicated with a strong anti-ulcerogenic potential. 7 It is also common knowledge that NSAIDs and ASA can cause ulcerations in the gastrointestinal (GI) tract of mammals, while other painkillers such as COX-2 inhibitors (Viox) do not cause GI bleeding. The in vitro studies of Jäger et al 8,9 clearly demonstrate that rose hip powder contains components that act mainly as a COX-2 inhibitor.…”

mentioning

confidence: 99%

“…55,56 Aqueous and more lipophilic extractions of rose hip have been tested in animal models with different results. 2,7,13,18 To the best of our knowledge, there are no randomized, placebo controlled clinical studies on extractions from rose hip tested on humans. We found one open uncontrolled observational study in humans with osteoarthritis, who were given an aqueous extraction of rose hip added to collagen hydrolysate.…”

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confidence: 99%

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The role of rose hip (Rosa canina L) powder in alleviating arthritis pain and inflammation – part II animal and human studies

Marstrand¹,

Campbell-Tofte²

2016

BTAT

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Rosa canina fruits (often known as rose hip) have been used in herbal remedies since ancient times. On the basis of anecdotal reports about the effects of rose hip preparations on human health and citations to the same in ancient texts, in vitro and in vivo studies have been conducted that have made it possible to learn about some active ingredients in rose hip, as well as how the component compounds might exert their effects. From such studies, it has been documented that there is a great variation in active ingredients when comparing different rose hip products. Factors which affect the quality and quantity of active ingredients in the rose hip products include the subspecies of the particular R. canina from which the fruits are harvested, the environment during plant growth, time of harvesting, and the amount of seeds and shells/husks incorporated into the preparation. Studies in animals and in humans are of great importance for determining the true bio-effects of rose hip. Such in vivo studies that have only been performed during the last 2 decades indicate that the treatment of patients with different types of joint disease with rose hip powder based on a subspecies of R. canina (Lito) containing a certain galactolipid (GOPO) can alleviate pain, improve daily activity, and even reduce the consumption of regular pain relievers. As several rose hip components have been shown to be anti-inflammatory, it is suggested that anti-inflammatory mechanisms might explain some reductions in symptoms associated with administering rose hip to arthritic conditions. Although the number of publications of randomized and placebo-controlled clinic studies with rose hip is small, the overriding evidence is that the anti-inflammatory effects from administration of rose hip preparations containing both shells and seeds are superior to preparations containing shells alone.

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Section: Studies In Ratscontrasting

confidence: 99%

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confidence: 99%

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confidence: 99%

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The role of rose hip (Rosa canina L) powder in alleviating arthritis pain and inflammation – part II animal and human studies

Marstrand¹,

Campbell-Tofte²

2016

BTAT

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“…A cupful of mucilage mixed with a ripe banana is given as a tonic food during the treatment of colitis, cystitis, hepatitis, and jaundice [15]. A gastroprotective effect of the methanolic extract of okra in ethanol-induced gastric ulcer in rats was reported [15,16]. OFG is inexpensive, consistent in quality, chemically inert, biodegradable, biocompatible in nature, and reliable in supply [8,17].…”

Section: Introductionmentioning

confidence: 99%

Extraction of Gum From Abelmoschus Esculentus: Physicochemical Peculiarity and Antioxidant Prepatent

Nagpal

Aggarwal

Jain

et al. 2017

Asian J Pharm Clin Res

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Objective: This study is aimed to extract gum from Abelmoschus esculentus using ultrasonic assisted method and exploring physicochemical, functional, and antioxidant potential of gum for food and pharmaceuticals. Materials and Methods:The extraction of gum from okra was done employing ultrasound-assisted method to improvise the yield. The extracted gum was further characterized for physical properties including swelling index, solubility, water sorption time, packing and flow properties, electrical properties, zeta potential, scanning electron microscopy, and antioxidant activity. Results:The extraction yield of okra fruit gum (OFG) was found to be 31.52%±0.22% (n=3). The OFG powder obtained after lyophilization showed good flow properties as determined from the results of angle of repose (34.21°), Hausner ratio (1.14), and % compressibility (12.5%). An increase in solubility and swelling index of OFG with increase in pH of buffer from 2.0 to 7.4 was observed. The freeze dried OFG possess rough surface and zeta potential of −9.85 mV. Application of derivatized/interacted OFG gum for modification of drug release profiles is concluded from high degree of esterification of 7.8. Conclusion:The result suggest that the antioxidant activity of OFG was higher compared to corn flour gum. Thus, OFG could be utilized as natural antioxidant food ingredients and also for application in medicine and health-care products.

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“…The mucilage of Bhindi has been used for treating various diseases such as diarrhea, dysentery, and gastric ulcer as calming softener. Alqasoumi [1] and Gürbüz et al [2] testified that extract of okra in methanol possessed a gastroprotective effect in rats suffering from gastric ulcer induced with ethanol. Okra mucilage, when mixed with ripe banana, possess its application in the treatment of various GIT diseases including colitis, cystitis, hepatitis, and jaundice [1].…”

Section: Introductionmentioning

confidence: 99%

Okra Fruit Gum-Chitosan Impregnated Polymer Network Films: Formulation and Substantial Depiction

Nagpal

Aggarwal

Jain

et al. 2017

Asian J Pharm Clin Res

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Objective: The present research is aimed at formulation and evaluation of okra fruit gum (OFG)-chitosan (CH) impregnated polymer network films. Methods:The film forming property of the gum attained from fruits of Abelmoschus esculentus was enhanced by co-processing it with CH. Estimation of properties including swelling index (SI), film volume, volume index, film surface contact angle with buffer solutions (pH 1.2, 7.4 or 6.8), work of adhesion (Wa), and spreading coefficient was done. Results:The contact angle and SI of OFG-CH film in both acidic and alkaline buffers were witnessed to be lowest when equated with the films prepared with difference in ratios of both gum and CH. Moreover, the Wa and spreading coefficient were less for this film. These results could be attributed to the optimum interaction between -COO − groups of gum and -NH3 + groups of CH. Conclusion:The actual nature of the film found to be tough, flexible, and water resistant. Hence, the results have shown that the films produced have a high potential for use in modified drug release and in food and pharmaceuticals.

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Anti-ulcerogenic activity of some plants used as folk remedy in Turkey

Cited by 136 publications

References 4 publications

The role of rose hip (Rosa canina L) powder in alleviating arthritis pain and inflammation – part II animal and human studies

The role of rose hip (Rosa canina L) powder in alleviating arthritis pain and inflammation – part II animal and human studies

Extraction of Gum From Abelmoschus Esculentus: Physicochemical Peculiarity and Antioxidant Prepatent

Okra Fruit Gum-Chitosan Impregnated Polymer Network Films: Formulation and Substantial Depiction

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Anti-ulcerogenic activity of some plants used as folk remedy in Turkey

Cited by 136 publications

References 4 publications

The role of rose hip (Rosa canina L) powder in alleviating arthritis pain and inflammation &ndash; part II animal and human studies

The role of rose hip (Rosa canina L) powder in alleviating arthritis pain and inflammation &ndash; part II animal and human studies

Extraction of Gum From Abelmoschus Esculentus: Physicochemical Peculiarity and Antioxidant Prepatent

Okra Fruit Gum-Chitosan Impregnated Polymer Network Films: Formulation and Substantial Depiction

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Product

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The role of rose hip (Rosa canina L) powder in alleviating arthritis pain and inflammation – part II animal and human studies

The role of rose hip (Rosa canina L) powder in alleviating arthritis pain and inflammation – part II animal and human studies