Anti-Ulcerative Potential of &lt;i&gt;Punica granatum&lt;/i&gt; L (Lythraceae) Hydroalcohol Fruit Peel Extract

Moghaddam, Ghazaleh; Sharifzadeh, Mohammad; Hassanzadeh, Gholamreza; Khanavi, Mahnaz; Dolatshahi, F; Sadeghi, Naficeh; Oveisi,; Hajimahmoodi, Mannan

doi:10.4314/tjpr.v13i7.12

Cited by 15 publications

(11 citation statements)

References 14 publications

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“…Gastric ulcer is the most widespread gastrointestinal tract disorders and gastric mucosa is recurrently exposed to several destructive and injurious factors [1] .…”

Section: Discussionmentioning

confidence: 99%

“…They include gastric and duodenal ulcer. Gastric ulcer is an interruption of the continuity of the gastric or duodenal mucosa that extends towards the muscularis mucosa and may reach deeper into submucosa [1][2][3] . It can cause major complications such as bleeding, perforation and finally death if associated with decompensating of coexisting medical conditions [1,4] .…”

Section: Introductionmentioning

confidence: 99%

“…For this reason, there is a need to search for alternative drug sources or natural products which are more effective and safe against gastric ulcers [3,7] . Nowadays, dietary antioxidants of natural products are considered as promising alternative therapy and may have several health benefits [1] . The pomegranate (Punica granatum L.) is vastly cultivated in Mediterranean countries as Egypt, Turkey, Tunisia, Spain, and Morocco [8,9] .…”

Section: Introductionmentioning

confidence: 99%

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Comparative study of the therapeutic effect of pomegranate alone or in combination with bone marrow mesenchymal stem cells on experimentally induced gastric ulcer in adult male rats: A histological and immunohistochemical study

El-Azab

Mansy

El-Mahalaway

et al. 2018

Egyptian Journal of Histology

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Introduction: Gastric ulcers are the most prevalent gastrointestinal disorders. Pomegranate fruits have many beneficial therapeutic effects. Bone marrow mesenchymal stem cells (BMSCs) are a novel approach with promising therapeutic potential for curing human diseases. Aim of the work: To evaluate the effect of pomegranate and BMSCs on experimentally induced gastric ulcer in adult male rats. Materials and Methods: Sixty adult male rats were divided into four groups. Group I kept as the control group. Group II (Gastric ulcer), rats received 100% ethanol orally by gastric tube. Group (III) subdivided into 3 subgroups. Subgroup IIIa included rats with gastric ulcer that treated with pomegranate only. Subgroup IIIb, rats with gastric ulcer treated with BMSCs alone. Subgroup IIIc; gastric ulcer rats treated with a combination of pomegranate and BMSCs. Group IV included the untreated gastric ulcer rats. Fundus of stomach specimens were prepared and examined using histological and immunohistochemical techniques. Results: Groups II and IV showed various changes as deep erosion, marked damage of most of the cells. The presence of the inflammatory cells in gastric mucosa were supported by a significant increase of tumor necrosis factor α (TNF-α) expression and collagen fibers depositions (P<0.01). A significant decrease of Periodic Acid Schiff (PAS) positive reaction and vascular endothelial growth factor (VEGF) expression was observed (P<0.01). Subgroup IIIa showed attenuation of some histological changes, while subgroups IIIb and IIIc revealed more improvement of the histological and immunohistochemical changes described before. Conclusion: BMSCs can ameliorate experimentally-induced gastric injury in rats and protect the gastric tissue. Addition of pomegranate to BMSCs can lead to better results.

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“…Gastric ulcer is the most widespread gastrointestinal tract disorders and gastric mucosa is recurrently exposed to several destructive and injurious factors [1] .…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparative study of the therapeutic effect of pomegranate alone or in combination with bone marrow mesenchymal stem cells on experimentally induced gastric ulcer in adult male rats: A histological and immunohistochemical study

El-Azab

Mansy

El-Mahalaway

et al. 2018

Egyptian Journal of Histology

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show abstract

“…Lesions of the mucosa ranging from hyperaemia at one extreme, through haemorrhagic lesions, and up to full erosions at the other extreme were recorded. The ulcer index of each animal was calculated by using the following scoring system [45]: -0 = normal coloured stomach; -0.5 = red coloration; -1 = spot ulceration; -1.5 = haemorrhagic streaks; -2 = ulcers between 3 and 5 mm in greatest dimension; -3 = ulcers greater than 5 mm in greatest dimension; -4 = perforations.…”

Section: Macroscopic and Ulcer Index Studymentioning

confidence: 99%

“…A dose of 50 mg/kg body weight was administered to the animals daily for 15 consecutive days, starting from 6 h after indomethacin administration [45].…”

Section: Chemicalsmentioning

confidence: 99%