Anti-ulcer constituents of Annona squamosa twigs

A natural source of medicine, Enicosanthellum pulchrum is a tropical plant which belongs to the family Annonaceae. In this study, methanol extract from the leaves and stems of this species was evaluated for its gastroprotective potential against mucosal lesions induced by ethanol in rats. Seven groups of rats were assigned, groups 1 and 2 were given Tween 20 (10% v/v) orally. Group 3 was administered omeprazole 20 mg/kg (10% Tween 20) whilst the remaining groups received the leaf and stem extracts at doses of 150 and 300 mg/kg, respectively. After an additional hour, the rats in groups 2–7 received ethanol (95% v/v; 8 mL/kg) orally while group 1 received Tween 20 (10% v/v) instead. Rats were sacrificed after 1 h and their stomachs subjected to further studies. Macroscopically and histologically, group 2 rats showed extremely severe disruption of the gastric mucosa compared to rats pre-treated with the E. pulchrum extracts based on the ulcer index, where remarkable protection was noticed. Meanwhile, a significant percentage of inhibition was shown with the stem extract at 62% (150 mg/kg) and 65% (300 mg/kg), whilst the percentage with the leaf extract at doses of 150 and 300 mg/kg was 63% and 75%, respectively. An increase in mucus content, nitric oxide, glutathione, prostaglandin E2, superoxide dismutase, protein and catalase, and a decrease in malondialdehyde level compared to group 2 were also obtained. Furthermore, immunohistochemical staining of groups 4–7 exhibited down-regulation of Bax and up-regulation of Hsp70 proteins. The methanol extract from the leaves and the stems showed notable gastroprotective potential against ethanol.

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“…Pendula. [14], Annona squamosa L. [15] and Annona reticulata L. [16]. Some of these have been traditionally used to treat peptic ulcers.…”

Section: Introductionmentioning

confidence: 99%

Anti-Ulcerogenic Effect of Methanolic Extracts from Enicosanthellum pulchrum (King) Heusden against Ethanol-Induced Acute Gastric Lesion in Animal Models

et al. 2014

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“…They reduce gastric acidity, pepsin and gastrin level, and inhibit H + -K + ATPase pump. The effect was comparable to that of Omeprazole [81]. This supports the traditional use of the twigs in peptic ulcers.…”

Section: Anti-ulcer Activitysupporting

confidence: 70%

Pharmacological Activities of <i>Annona squamosa</i>: Updated Review

Oo¹

2017

IJPC

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Abstract:Annona squamosa is a medicinal plant which has been used in alternative medicine from ancient times. Different parts of Annona squamosa such as fruits, seeds, leaves and barks have been used to treat many diseases. Some of the active constituents have been identified and investigated for biological actions while the rest are yet to be explored. Current understanding of pharmacological properties of Annona squamosa not only supports alternative medicine but also contributes to the development of potential drugs for certain diseases. Therefore, an updated review on pharmacological actions of Annona squamosa is in urgent need. The purpose of this review is to provide current understanding of important pharmacological properties of Annona squamosa. The information provided in this article could be used to proceed to the designation and development of new pharmacological agents prepared from Annona squamosa for commonly encountered diseases.

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“…In NSAIDs-model, the lower effective dose for both species, SOL (100 mg/kg) and ACL (50 mg/kg) signifi cantly reduced ulcer occurrence in the NSAIDs induced model (73 and 63% inhibition; respectively), supporting its cytoprotective effect, which may be mediated by prostaglandin production ( Figure 2). Other species of the genus Annona (Annona muricata L. and Annona squamosa) were active against gastric ulcers, increased the mucus secretion and PGE production [19,20]. The identifi cation by 1 H NMR of secondary metabolites classes present on the ethanolic extracts from leaves of S. odoratissima and A. coriacea was based on characteristic chemical shifts (ppm) of them and literature data of isolated compounds from these species.…”

Section: Resultsmentioning

confidence: 99%

Antiulcerogenic activity of species Annona coriacea Mart. and Spiranthera odoratissima A. St. Hil

Anderson¹

2017

Arch Clin Gastroenterol

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Background: Medicinal plants from the Brazilian Cerrado are used in folk medicine to treat several diseases such as gastric disorders.Purpose: The present work evaluated the antiulcerogenic and antimicrobial effects of the ethanolic extracts obtained from leaves of two Cerrado plant species. Methods:The action of ethanolic extracts of Spiranthera odoratissima (SOL) and Annona coriacea (ACL) were evaluated in experimental in vivo models in rats that simulated this disease in human gastric mucosa. Additionally, a pharmacological study to test antimicrobial activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa were also evaluated by microdilution methods.Results: The pretreated with SOL (100, 200 and 300 mg/kg, p.o.) promoted signifi cant inhibition of mucosal injury (93, 99 and 98% inhibition; respectively). This inhibition also was detected in ACL treatment (50, 100, 200 and 300 mg/kg; 67, 52, 48 and 67% inhibition, respectively). The both extracts SOL (100 mg/ kg) and ACL (50 mg/kg) also reduced signifi cantly the formation of gastric lesions induced by indomethacin (73 and 63%, respectively) when compared to animals treated with respective vehicle. The phytochemical profi le from SOL and ACL indicated the presence alkaloids as a main constituent of these extracts. ACL but not displayed antimicrobial activities in vitro. Conclusion:Spiranthera odoratissima and Annona coriacea species present gastroprotective activity, supporting previous claims that its traditional use can treat gastrointestinal disorders.

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Anti-ulcer constituents of Annona squamosa twigs

Cited by 63 publications

References 31 publications

Anti-Ulcerogenic Effect of Methanolic Extracts from Enicosanthellum pulchrum (King) Heusden against Ethanol-Induced Acute Gastric Lesion in Animal Models

Anti-Ulcerogenic Effect of Methanolic Extracts from Enicosanthellum pulchrum (King) Heusden against Ethanol-Induced Acute Gastric Lesion in Animal Models

Pharmacological Activities of <i>Annona squamosa</i>: Updated Review

Antiulcerogenic activity of species Annona coriacea Mart. and Spiranthera odoratissima A. St. Hil

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Anti-ulcer constituents of Annona squamosa twigs

Cited by 63 publications

References 31 publications

Anti-Ulcerogenic Effect of Methanolic Extracts from Enicosanthellum pulchrum (King) Heusden against Ethanol-Induced Acute Gastric Lesion in Animal Models

Anti-Ulcerogenic Effect of Methanolic Extracts from Enicosanthellum pulchrum (King) Heusden against Ethanol-Induced Acute Gastric Lesion in Animal Models

Pharmacological Activities of &lt;i&gt;Annona squamosa&lt;/i&gt;: Updated Review

Antiulcerogenic activity of species Annona coriacea Mart. and Spiranthera odoratissima A. St. Hil

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Pharmacological Activities of <i>Annona squamosa</i>: Updated Review