Anti-Ulcer Activity of<i>Teucrium polium</i>

Twaij, Husni A.A.; Al-Badr, Ammar A.; Abul-Khail, Ali

doi:10.3109/13880208709088138

Cited by 16 publications

(11 citation statements)

References 2 publications

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“…Traditionally TP is used for its antispasmodic and hypoglycemic activities by the native inhabitants and is recommended by the herbalists (Ali-Shtayeh et al, 2000;Abu-Irmaileh and Afifi, 2003). It is also known for its anti-ulcer, anti-inflammatory, antihypertensive, antinociceptive, and anorexic effects (Twaij et al, 1987;Tariq et al, 1989;Suleiman et al, 1998;Abdollahi et al, 2003;Baluchnejadmojarad et al, 2005;Gharaibeh et al, 1989). Nevertheless, the effect of the TP plant extract on human cancer remains to be determined.…”

Section: Introductionmentioning

confidence: 96%

Teucrium polium plant extract inhibits cell invasion and motility of human prostate cancer cells via the restoration of the E-cadherin/catenin complex

Kandouz

Alachkar

Zhang

et al. 2010

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 96%

Teucrium polium plant extract inhibits cell invasion and motility of human prostate cancer cells via the restoration of the E-cadherin/catenin complex

Kandouz

Alachkar

Zhang

et al. 2010

Journal of Ethnopharmacology

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“…The species are mainly distributed in central and southern America, southeast Asia, and Mediterranean region (Kandouz et al, 2010;Miri et al, 2012). The extract isolated from Teucrium species has been used for treatment of diabetes, obesity, inflammation, and hyperlipidemia (Twaij et al, 1987;Tariq et al, 1989;Miri et al, 2012). Also, there are reports on antioxidant, anticancer, and antibacterial activities of some Teucrium species (Kadifkova Panovska et al, 2005;Miri et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Anticancer Properties of Teucrium persicum in PC-3 Prostate Cancer Cells

Tafrihi

Toosi²,

Minaei³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Crude extracts or phytochemicals obtained from some plants have potential anti-cancer properties. Teucrium persicum is an Iranian endemic plant belonging to the Lamiaceae family which has traditionally been used to relieve abdominal pains. However, the anti-cancer properties of this species of the Teucrium genus have not been investigated previously. In this study, we have used a highly invasive prostate cancer cell line, PC-3, which is an appropriate cell system to study anti-tumor properties of plants. A methanolic extract obtained from T persicum potently inhibited viability of PC-3 cells. The viability of SW480 colon and T47D breast cancer cells was also significantly decreased in the presence of the T persicum extract. Flow cytometry suggested that the reduction of cell viability was due to induction of apoptosis. In addition, the results of wound healing and gelatin zymography experiments supported anti-cell invasion activity of T persicum. Interestingly, sublethal concentrations of T persicum extract induced an epithelial-like morphology in a subpopulation of cells with an increase in E-Cadherin and β-Catenin protein levels at the cell membrane. These results strongly suggest that T persicum is a plant with very potent anti-tumor activity

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“…The results obtained from the present studies showed that the oral administration of the aerial parts of Artemisea herba alba to glucose-fed, and to alloxan-induced diabetic rats and rabbits produced significant hypoglycemic activity (Twaij et al, 1987a). The aerial aqueous extract of both Phangnalon rupestre and Eryngium creticum also exhibited a potent and significant hypoglycemic effects in normal-fed and glucose loaded rats A-Jaleel and Twaij, 2002).…”

Section: Anti-diabetic and Hypoglycemic Studymentioning

confidence: 53%

Evaluation of the Anti-Diabetic and Anti-Ulcer Properties of Some Jordanian and Iraqi Medicinal Plants; a Screening Study

Twaij¹,

Al-Dujaili²

2014

JMED

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A large number of Jordanian and Iraqi medicinal plants have been used in traditional medicine for hypoglycemic and anti-ulcer activities. We have started a screening program to evaluate the activity of some of these plants and their extracts taking in consideration their use as an alternative therapy. Various parts of several plants were extracted and the hypoglycemic effects of the aqueous extracts have been examined in normal, glucose loaded and alloxan diabetic experimental animals. Teucrium polium aqueous extract was studied for its anti-ulcer activity of ulcers induced in rats by starvation and reserpine and/or stress. The aqueous extract of the aerial parts of Artemisia herba alba was administered orally to normoglycemic and alloxan diabetic rabbits and rats and found to produce a significant hypoglycemic activity (normoglycaemic: plasma glucose levels reduced from 116±4 to 90±3mg/dL after 90minutes, p<0.001; diabetic animals from 471±7 to 399±9mg/dL, p<0.001). The aerial aqueous extract of Phangnalon rupestre, Sinapis arvensis and Eryngium creticum also exhibited significant hypoglycemic effects in euglycaemic and glucose loaded rats. The other plants examined (Ditrichia graveolens, Alkanna strigosa, , Centaurea iberica, Asphodelin lutea, Paronychia argentea, rosmarinus officinalis, Achillea santolina, Achillea micrantha, Allium sativum, Centaurea phyllacephala, Centaurea behen, Crataegus azarolus, Prosopis farcta and Myrtus communis) failed to produce a significant change in the plasma glucose levels. One herb was comprehensively tested in detail for its anti-ulcer activity; Teucrium polium aqueous extract (intraperitoneally;150mg/kg) produced an average of 50% healing of ulcers where as the orally administered extract produced 85% healing activity of ulcers when compared with the controls.

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Anti-Ulcer Activity ofTeucrium polium

Cited by 16 publications

References 2 publications

Teucrium polium plant extract inhibits cell invasion and motility of human prostate cancer cells via the restoration of the E-cadherin/catenin complex

Teucrium polium plant extract inhibits cell invasion and motility of human prostate cancer cells via the restoration of the E-cadherin/catenin complex

Anticancer Properties of Teucrium persicum in PC-3 Prostate Cancer Cells

Evaluation of the Anti-Diabetic and Anti-Ulcer Properties of Some Jordanian and Iraqi Medicinal Plants; a Screening Study

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