Anti-tyrosinase, total phenolic content and antioxidant activity of selected Sudanese medicinal plants

Muddathir, Ali Mahmoud; Yamauchi, Kosei; Batubara, Irmanida; Mohieldin, Ebtihal Abdalla M.; Mitsunaga, Tohru

doi:10.1016/j.sajb.2016.12.013

Cited by 91 publications

(52 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These findings were well positioned within the broad range of total polyphenols (19.00–10,133.00 mg GAE/100 g) in numerous medicinal plants (Li et al, ) and the range 28.0–1,887.0 mg GAE/100 g in many oil‐bearing plants (Alu'datt et al, ). However, relatively high content of total phenolic of Argel leaves methanolic extract (3,290.00 mg GAE/100 g) has recently been reported (Muddathir, Yamauchi, Batubara, Mohieldin, & Mitsunaga, ). The discrepancy between these studies could be attributed to the differences in the genetic makeup, growing environment, growth stage, harvesting time, handling processes and storage, and extracting solvents and methods.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Argel (Solenostemma argel) leaf powder on the quality attributes of camel patties during cold storage

Al‐Juhaimi

Ahmed

Adiamo

et al. 2017

J Food Process Preserv

View full text Add to dashboard Cite

The phytochemical composition and antioxidant activity of Argel leaf powder (ALP) and its effect on the quality attributes of camel patties were investigated. ALP contains substantial amounts of total phenolics (1,262.50 mg GAE/100 g), and anthocyanin (60.11 µmol/g) and possesses high 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) scavenging activity (86.85%). The major phenolic compounds in ALP were isorhamnetin, (+)‐catechin, catechol, gallic acid, and protocatechuic acid. Increasing the concentration of ALP in camel patties improved (p ≤ .05) the protein and fat contents, cooking yield, moisture and fat retention, total phenolic content, DPPH, redness (a), yellowness (b), pH, and microbiological stability, while the dimensional shrinkage, TBARS, and lightness (L) were reduced. Throughout the storage period, the ALP formulated camel patties revealed better stability of the physicochemical, oxidation, microbiological, and sensory attributes compared to nonformulated patties. Generally, the findings of this study proved the antioxidant and antimicrobial potentials of 4–6% ALP as a functional additive to preserve patties. Practical applications Natural herbs play an important role in preserving sensitive foods. Camel meat is highly subjected to microbial and chemical spoilage as they are rich in essential nutrients. The adverse effects of different chemical preservatives attract the consumer's attention to natural alternatives. Therefore, in order to increase the shelf life and quality characteristics of camel meat, new processing technologies and new ingredient systems that are associated with natural herbs are applied. These results showed that the potentiality of Argel powder in the development of novel healthy meat products with improved shelf life and superior product quality was high.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Mitsunaga, 2017). The discrepancy between these studies could be attributed to the differences in the genetic makeup, growing environment, growth stage, harvesting time, handling processes and storage, and extracting solvents and methods.…”

mentioning

confidence: 99%

Effect of Argel (Solenostemma argel) leaf powder on the quality attributes of camel patties during cold storage

Al‐Juhaimi

Ahmed

Adiamo

et al. 2017

J Food Process Preserv

View full text Add to dashboard Cite

show abstract

“…The molecular mechanism of these skin lightening agents is to decrease the melanin production that determines skin color. Tyrosinase is a key enzyme involved in melanin biosynthesis and therefore, inhibitors of this enzyme may lead to novel skin whitening agents that are safer and effective in comparison to the currently available ones [36]. From this standpoint, we assessed the anti-tyrosinase effect of the studied extracts and we observed that only the methanolic extracts obtained using the maceration and Soxhlet methods of C. szovitsii subsp.…”

Section: Enzyme Inhibitory Activitymentioning

confidence: 99%

Chemical Profiling and Biological Properties of Extracts from Different Parts of Colchicum Szovitsii Subsp. Szovitsii

et al. 2019

View full text Add to dashboard Cite

Like other members of the Colchicum genus, C. szovitsii subsp. szovitsii is also of medicinal importance in Turkish traditional medicine. However, its biological properties have not been fully investigated. Herein, we focused on the evaluation of the in vitro antioxidant and enzyme inhibitory effects of flower, root and leaf extracts, obtained using different extraction methods. In addition, a comprehensive (poly)-phenolic and alkaloid profiling of the different extracts was undertaken. In this regard, ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) allowed us to putatively annotate 195 polyphenols and 87 alkaloids. The most abundant polyphenols were flavonoids (83 compounds), whilst colchicine and 2-demethylcolchicine were some of the most widespread alkaloids in each extract analyzed. However, our findings showed that C. szovitsii leaf extracts were a superior source of both total polyphenols and total alkaloids (being, on average 24.00 and 2.50 mg/g, respectively). Overall, methanolic leaf extracts showed the highest (p < 0.05) ferric reducing antioxidant power (FRAP) reducing power (on average 109.52 mgTE/g) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging (on average 90.98 mgTE/g). Interestingly, each C. szovitsii methanolic extract was more active than the water extracts when considering enzymatic inhibition such as against tyrosinase, glucosidase, and acetylcholinesterase (AChE). Strong correlations (p < 0.01) were also observed between polyphenols/alkaloids and the biological activities determined. Multivariate statistics based on supervised orthogonal projections to latent structures discriminant analysis (OPLS-DA) allowed for the detection of those compounds most affected by the different extraction methods. Therefore, this is the first detailed evidence showing that C. szovitsii subsp. szovitsii might provide beneficial effects against oxidative stress and the associated chronic diseases. Nevertheless, the detailed mechanisms of action need to be further investigated.

show abstract

“…EAF demonstrated the strongest inhibition on tyrosinase, which was approximately 18.77‐fold of that of n BuF, and there was no significant difference between EAF and kojic acid, a well‐known positive control in screening new tyrosinase inhibitors from plants. The extracts and fractions all exhibited potent tyrosinase inhibition (especially EAF), most likely due to their strong antioxidant activity, and the hydroxyl groups of polyphenols present in fractions could form a hydrogen bond with the site of the enzyme, resulting in lower enzymatic activity (Fatiha et al, ; Muddathir et al, ).…”

Section: Resultsmentioning

confidence: 99%

“…However, over production and accumulation of melanin can cause significant pathological conditions, such as melasma, senile lentigos, solar melanosis, ephelides, even skin cancers, and postinflammatory hyperpigmentation (Di Petrillo et al, ; Lee, Baek, & Nam, ). Tyrosinase is the pivotal enzyme for melanin biosynthesis to catalyze the transformation of L‐tyrosine to 3,4‐dihydroxyphenylalanine (DOPA) and oxidize DOPA to dopaquinone (Muddathir, Yamauchi, Batubara, Mohieldin, & Mitsunaga, ). Since tyrosinase is the limiting enzyme for melanogenesis, its inhibitors are increasingly important as a pigmentation depigmenting agent.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, metabolic enzymes inhibitory ability of Torreya grandis kernels, and phytochemical profiling identified by HPLC‐QTOF‐MS/MS

Zhu

Zhang

et al. 2019

J Food Biochem

View full text Add to dashboard Cite

In this study, the antioxidant activities, α‐glucosidase and tyrosinase inhibitory ability of Torreya grandis kernels (TGK) were performed. Samples were extracted with various polarity of ethanol, and the major phytochemical profile was characterized. The results showed that 70% of ethanol extract gave the richest phenolics and flavonoids. The strongest DPPH· and ABTS·+ scavenging ability, as well as the best inhibition on tyrosinase and α‐glucosidase was also detected on 70% of ethanol extract. Among the fractions of 70% of ethanol extract, the ethyl acetate fraction (EAF) owned the highest phenolics, flavonoids, and the best DPPH· and ABTS·+ scavenging ability, and tyrosinase inhibition. Unexpectedly, the dichloromethane fraction possessed the strongest inhibition on α‐glucosidase, which was much greater than that of acarbose. HPLC‐QTOF‐MS/MS analysis result to the characterization of 19 compounds from EAF. The results implied that TGK can be a potential source of natural antioxidants, α‐glucosidase and tyrosinase inhibitors. Practical applicationsThe kernels of T. grandis are one of the precious nuts in the world, and the extracts were advertised to show a variety of biological activities and pharmacological effects. However, researches on the phytochemical constituents and bioactivities are fewer. In this study, TGK was found to show good potency in antioxidant, α‐glucosidase and tyrosinase inhibitory activities. The 70% ethanol is the best solvent for extracting above mentioned active components, and ethyl acetate can be the suitable enriching solvent. In addition, the predominant phytochemical compounds in EAF were characterized. Therefore, this research can help to the performance of further research and application of TGK in functional products.

show abstract

Anti-tyrosinase, total phenolic content and antioxidant activity of selected Sudanese medicinal plants

Cited by 91 publications

References 50 publications

Effect of Argel (Solenostemma argel) leaf powder on the quality attributes of camel patties during cold storage

Effect of Argel (Solenostemma argel) leaf powder on the quality attributes of camel patties during cold storage

Chemical Profiling and Biological Properties of Extracts from Different Parts of Colchicum Szovitsii Subsp. Szovitsii

Antioxidant, metabolic enzymes inhibitory ability of Torreya grandis kernels, and phytochemical profiling identified by HPLC‐QTOF‐MS/MS

Contact Info

Product

Resources

About