Anti-tumour effects of elatol, a marine derivative compound obtained from red algae Laurencia microcladia

Campos, Andreza; Souza, C. B. L. de; Lhullier, Cíntia; Falkenberg, Miriam; Schenkel, Eloir Paulo; Ribeiro‐do‐Valle, Rosa Maria; Siqueira, Jarbas Mota

doi:10.1111/j.2042-7158.2012.01493.x

Cited by 64 publications

(53 citation statements)

References 36 publications

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“…This substance showed of IC 50 1.1 µM in L929 cells and IC 50 of 10.1 µM in B16F10 cells. It also caused a delay in the transition from the G1/S phase of the cell cycle and induces apoptosis [84].…”

Section: Red Seaweeds As a Source Of New Bioactive Prototypesmentioning

confidence: 99%

Seaweeds as Source of New Bioactive Prototypes

Nogueira¹,

Teixeira²

2016

Algae - Organisms for Imminent Biotechnology

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Living organisms endowed with natural benefits have been used for millions of years in the medical practice. Seaweeds have been widely used around the world for the production of agar and food; however, the pharmaceutical industry has drawn attention to the activities of these natural products. In this chapter, we present some bioactive metabolites of the three phyla of seaweed (green, brown, and red algae) along with their potential for drug development.

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Section: Red Seaweeds As a Source Of New Bioactive Prototypesmentioning

confidence: 99%

Seaweeds as Source of New Bioactive Prototypes

Nogueira¹,

Teixeira²

2016

Algae - Organisms for Imminent Biotechnology

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“…(2012) shows an anticancer effect by reducing cell viability of B16F10 (melanoma murine), A549 (human lung carcinoma), DU145 (carcinoma of human prostate), L929 (mouse fibroblasts), and MCF-7 (human breast adenocarcinoma). In addition, treatment with elatol was able to reduce tumor growth in vivo in mice inoculated by B16F10 cells (Campos et al, 2012). Another study indicates that the polyether of Laurencia viridis has cytotoxic activity against human cancer cell lines Jurkat (acute T cell leukemia), MM144 (myeloma), HeLa (cervix adenocarcinoma), and CADO-ES1 (Ewing sarcoma human).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Cytotoxic Activity of Laurencia papillosa, Marine Red Algae from the Lebanese Coast

2017

J App Pharma Sci

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Marine algae are an excellent source of bioactive compounds with a variety of biological activities. This paper presents a study on the cytotoxic activity of Laurencia papillosa (Rhodomelaceae), marine red algae collected at the Lebanese coast against the human cancer cell line Jurkat (acute lymphoblastic leukemia) through the trypan blue exclusion assay. The results show that the percentage of cell viability was reduced by increasing the concentration of both algal extracts: ethanol/ water extract, and ethanol/ chloroform extract. The ethanol/ chloroform extract exhibits the highest levels of cytotoxicity with IC50 value of 57.77 µg/ mL against Jurkat cancer cell line especially after 72 hours of treatment compared with the ethanol/water extract with IC50 value of 121.642 µg/ mL. Further research should be explored in order to study the bioactive compounds of Laurencia papillosa that could be potentially useful therapeutic agents for patients with acute lymphoblastic leukemia.

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“…2 c) isolated from Laurencia microcladia, down regulate the cyclin-D1, cyclin-E, cyclin-dependent kinase (Cdk) 2 and cdk4. Elatol has been reported to decrease the expression of bcl-xl and an increase in bak, caspase-9 and p53 expression resulting in activation of the apoptotic process in in vivo condition in C57Bl6 mice [32].…”

Section: Laurenciamentioning

confidence: 99%

Algae as potential repository of anti cancerous natural compounds

Mridha¹,

Paul²

2017

ijpm

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Algae constitute a promising source of novel compounds with potential as human therapeutic agents. In particular, algae have been considered as a potential source of new bio-active compound. Algae possess several biological activities, including anticancer activity. This review provides a comprehensive report on the several genera of algae belonging to Chlorophyceae, Pheophyceae and Rhodophyceae having anti-proliferative, apoptotic, anti angiogenic as well as cytotoxic efficacy and their mode of action in vitro as well as in vivo condition. Algae are extensively used as functional foods and medicinal herbs, and have a long history of use in Asian countries. Many algae have been used for the treatment of cancer, many crude or partially purified polysaccharides from various brown, green, and red algae have been tested for their antitumor activities. Relevant information was collected from scientific journals, books, and reports via library and electronic search using Medline, Pubmed, Science Direct, and Scopus. The different extracts with some other solvent shows a huge anti-proliferative action on different cancer as well as on different leukemia cell lines. Here we focus on several bioactive compounds that have been derived as well as characterized from different genera of algae and there mechanism of inhibiting cancer cell growth. Considering the ability of the golden treasure present in algae to act against different cancers, this review highlights the potential use of algae as anticancer agents.

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Anti-tumour effects of elatol, a marine derivative compound obtained from red algae Laurencia microcladia

Cited by 64 publications

References 36 publications

Seaweeds as Source of New Bioactive Prototypes

Seaweeds as Source of New Bioactive Prototypes

In Vitro Cytotoxic Activity of Laurencia papillosa, Marine Red Algae from the Lebanese Coast

Algae as potential repository of anti cancerous natural compounds

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