Anti-tumor effects of PC-SPES, an herbal formulation in prostate cancer.

PC-SPES and Prostate Cancer

“…We have demonstrated that incorporating PC-SPES into the Copenhagen rat diet significantly protects rats from trans-plantable MAT-LyLu tumor cells (Tiwari et al 1999). This is noteworthy because the MAT-LyLu cell line is nonimmunogenic and highly resistant to treatment.…”

PC-SPES: A unique inhibitor of proliferation of prostate cancer cells in vitro and in vivo

“…However, after taking PC-SPES for 6 months or longer, testosterone returned to near normal, while PSA continued to remain low in a cohort of the patients. Independently, Hsieh et al [36] found that PC-SPES enhanced immune function by downregulation of the bcl-6 gene, which in turn modulated T-and B-lymphocytes. These results strongly suggest that the action of PC-SPES results from more than just an estrogenic effect.…”

Saw Palmetto induces growth arrest and apoptosis of androgen-dependent prostate cancer LNCaP cells via inactivation of STAT 3 and androgen receptor signaling

“…One of the herbal mixtures frequently used by individuals with prostate cancer is the Chinese herbal mixture denoted PC-SPES (17)(18)(19)(20)(21)(22)(23)(24) Scutellaria baicalensis, Georgi and Serenoa repens (17)(18)(19)(20)(21)(22)(23)(24). Previous studies showed that PC-SPES mediated an antiproliferative effect on prostate cancer cells in vivo and in vitro (16)(17)(18)(19)(20)(21)(22)(23)(24)(25). In addition, recent clinical studies showed that PC-SPES reduced prostate specific antigen (PSA) levels in more than 80% of individuals with prostate cancer (26,27).…”