Anti-tumor effect of Scutellaria barbata D. Don extracts on ovarian cancer and its phytochemicals characterisation

Zhang, Lin; Ren, Baoyin; Zhang, Jing; Liu, Likun; Liu, Jia; Jiang, Guoqiang; Li, Man; Ding, Yanfang; Li, Weiling

doi:10.1016/j.jep.2017.05.032

Cited by 47 publications

(32 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence, its name "the miracle root for the preservation of life". Scutellaria barbata has a potent antitumor activity in breast cancer [17], colorectal cancer [18], hepatocarcinoma [19], skin cancer [20], lung cancer [21], and ovarian cancer [22]. Moreover, Lee et al, (2017) [23] reported that the active fractions of Scutellaria barbata have antiinflammatory activity in BV-2 cells.…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of gold nanoparticles from Scutellaria barbata and its anticancer activity in pancreatic cancer cell (PANC‐1)

Wang

Yan

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

103

View full text Add to dashboard Cite

Nanotechnology has been materialized as a proficient technology for the development of anticancer nanoparticles all the way through an environment-friendly approach. Conventionally, nanoparticles have been assembled by dissimilar methods, but regrettably rely on the negative impact on the natural environment. Amalgamation of nanoparticles by means of plant extract is alternate conservative methods. Scutellaria barbata species was used majorly as food or as medicines against various diseases, and extensive research was conducted for their therapeutic properties. The present research was mainly focused on the synthesis of gold nanoparticles from the Scutellaria barbata by green route method and evaluation of its anticancer activity against pancreatic cancer cell lines (PANC-1). The gold nanoparticles have been characterized by UV-visible spectroscopy, TEM, SAED, AFM, and FTIR analysis. The synthesized gold nanoparticles (AuNPs) possessed effective anticancer activity against pancreatic cancer cell lines (PANC-1). Hence, further research on this plant may lead to the development of novel anticancer drugs which can be used to combat pancreatic cancer.

show abstract

Section: Introductionmentioning

confidence: 99%

Green synthesis of gold nanoparticles from Scutellaria barbata and its anticancer activity in pancreatic cancer cell (PANC‐1)

Wang

Yan

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

103

View full text Add to dashboard Cite

show abstract

“…Tumour/cancer is one of the leading causes of disease‐related death in both men and women in the world, and increasing investigations have revealed that natural products derived from plants might be good sources for searching candidate antitumour agents . The previous researches also revealed that a great number of Chinese medicines possess potential antitumour effects, such as Hedyotis diffusa , Toona sinensis and Scutellaria barbata . Importantly, lots of previous investigations have also indicated that extracts/monomers from Cinnamomi ramulus possess antitumour effects against various cancers/tumours.…”

Section: Methodsmentioning

confidence: 99%

The traditional uses, phytochemistry, pharmacology and toxicology of Cinnamomi ramulus: a review

Liu

Zhang

et al. 2019

Journal of Pharmacy and Pharmacology

Self Cite

View full text Add to dashboard Cite

Objectives Cinnamomi ramulus (called Guizhi in Chinese) is a traditional medicine used to treat gastrointestinal dysfunction, cancer, arthritis, osteoporosis, spleen deficiency, Alzheimer's disease and obesity. This review aimed to provide a systematic summary on the geographical distribution, botany, traditional application, phytochemistry, pharmacology, pharmacokinetics, toxicology and other aspects of Cinnamomi ramulus. Key finding So far, more than 121 chemical compounds have been isolated from Cinnamomi ramulus, including volatile oil, organic acids, triterpenoid saponins, coumarins, tannins, flavonoids and flavonoid glycosides, steroids and polysaccharides. This paper reviews the pharmacological effects of Cinnamomi ramulus on antibacterial, anti-inflammatory, antiviral, antitumour, antipyretic and analgesic, antidiabetic and antiplatelet aggregation effects. Furthermore, the present review also indicates that Cinnamomi ramulus has the potential to develop into drugs for treating various diseases with high efficacy and low toxicity. Summary The convictive evidence from modern pharmacology research supports the traditional application of Cinnamomi ramulus. However, further studies on the structure-activity relationship of some of the isolated compounds may improve their biological potency. More toxicological studies will also contribute to the progress of clinical trial studies.

show abstract

“…Scutellaria barbata D. Don has been used to treat various cancers in China [ 39 , 40 , 41 ]. Wong et al’s in vivo data showed that S. barbata (32 mg/day) delayed tumor development in a transgenic prostate adenocarcinoma mouse model ,and the complementary in vitro data indicated that S. barbata (1 mg/mL) might exert this function by upregulating the apoptotic pathway and downregulating the survival pathway in TRAMP-C1 and LNCaP prostate cancer cells [ 42 ].…”

Section: Chinese Medicine Extracts Inhibit Prostate Cancermentioning

confidence: 99%

Chinese Medicines in the Treatment of Prostate Cancer: From Formulas to Extracts and Compounds

2018

View full text Add to dashboard Cite

In order to fully understand the progresses and achievements in Chinese medicines for the treatment of prostate cancer, we summarize all the available reports on formulas, extracts, and compounds of Chinese medicines against prostate cancer. A number of clinical trials verified that traditional Chinese formulas had some unique advantages in the treatment of prostate cancer. Many Chinese medicine extracts could protect against prostate cancer, and many compounds isolated from Chinese traditional medicines showed a clear anti-prostate cancer effect. However, Chinese medicines are facing many problems regarding their multicomponent nature, complicated mechanisms of action, and high doses required for therapy. Herein, we review the functions of Chinese medicines in prostate cancer and focus on their mechanisms. The review will deepen the understanding of Chinese medicines potential in the anti-prostate cancer field. In addition, we put forward a question concerning the current research on Chinese medicines: in order to better illustrate that Chinese medicines can be used in the clinical treatment of prostate cancer, should our research focus on formulas, extracts, or compounds?

show abstract

Anti-tumor effect of Scutellaria barbata D. Don extracts on ovarian cancer and its phytochemicals characterisation

Cited by 47 publications

References 22 publications

Green synthesis of gold nanoparticles from Scutellaria barbata and its anticancer activity in pancreatic cancer cell (PANC‐1)

Green synthesis of gold nanoparticles from Scutellaria barbata and its anticancer activity in pancreatic cancer cell (PANC‐1)

The traditional uses, phytochemistry, pharmacology and toxicology of Cinnamomi ramulus: a review

Chinese Medicines in the Treatment of Prostate Cancer: From Formulas to Extracts and Compounds

Contact Info

Product

Resources

About