Anti-tumor effect of local injectable hydrogel-loaded endostatin alone and in combination with radiotherapy for lung cancer

Wang, Na; Gao, Qin; Tang, Juan; Jiang, Yiqing; Yang, Liu; Shi, Xiangxiang; Chen, Yue; Zhang, Yan; Fu, Shaozhi; Lin, Sheng

doi:10.1080/10717544.2020.1869864

Cited by 15 publications

(14 citation statements)

References 41 publications

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“…Numerous injectable hydrogels have been developed over the past years ( 121 ). Injectable hydrogels offer many advantages, including good biocompatibility and biodegradability, minimal invasion, convenient synthesis, versatility, high drug-loading capacity, and controlled drug release ability ( 122 ).…”

Section: Discussionmentioning

confidence: 99%

“…Hydrogels provide a promising platform for the co-delivery of multiple agents targeting various components of the TME while causing minimal systemic toxicity. In addition, injectable hydrogels can also be combined with conventional treatments, such as radiotherapy and chemotherapy, to transform immunosuppressive TME to a pro-inflammatory state and amplify the antitumor immune response ( 50 , 121 , 125 ).…”

Section: Discussionmentioning

confidence: 99%

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Injectable Hydrogel as a Unique Platform for Antitumor Therapy Targeting Immunosuppressive Tumor Microenvironment

et al. 2022

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Cancer immunotherapy can boost the immune response of patients to eliminate tumor cells and suppress tumor metastasis and recurrence. However, immunotherapy resistance and the occurrence of severe immune-related adverse effects are clinical challenges that remain to be addressed. The tumor microenvironment plays a crucial role in the therapeutic efficacy of cancer immunotherapy. Injectable hydrogels have emerged as powerful drug delivery platforms offering good biocompatibility and biodegradability, minimal invasion, convenient synthesis, versatility, high drug-loading capacity, controlled drug release, and low toxicity. In this review, we summarize the application of injectable hydrogels as a unique platform for targeting the immunosuppressive tumor microenvironment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Injectable Hydrogel as a Unique Platform for Antitumor Therapy Targeting Immunosuppressive Tumor Microenvironment

et al. 2022

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“…RE loading into liposomes has also been used in a nanoformulation that was used as a mode of gene therapy with strong anti-tumour effects in vivo [ 95 ]. Nanoformulations of RE have also been studied in combination with RT [ 96 ]. Using hyaluronic acid-tyramine as a carrier, an ES-loaded hydrogel drug (ES/HA-Tyr) was synthesized for local injection [ 96 ].…”

Section: Endostatin and Its Mechanism Of Actionmentioning

confidence: 99%

“…Nanoformulations of RE have also been studied in combination with RT [ 96 ]. Using hyaluronic acid-tyramine as a carrier, an ES-loaded hydrogel drug (ES/HA-Tyr) was synthesized for local injection [ 96 ]. The ES/HA-Tyr formulation increased local drug concentration, decreased blood drug concentration, and caused less systemic toxicity in an in vivo study design.…”

Section: Endostatin and Its Mechanism Of Actionmentioning

confidence: 99%

Recombinant Endostatin as a Potential Radiosensitizer in the Treatment of Non-Small Cell Lung Cancer

et al. 2023

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Non-small cell lung cancer (NSCLC) is the most prevalent type of lung cancer, which is the leading cause of cancer-related deaths worldwide. Over the past decades, tumour angiogenesis has been intensely studied in the treatment of NSCLC due to its fundamental role in cancer progression. Several anti-angiogenic drugs, such as recombinant endostatin (RE), have been evaluated in several preclinical and clinical trials, with mixed and often disappointing results. However, there is currently an emerging interest in RE due to its ability to create a vascular normalization window, which could further improve treatment efficacy of the standard NSCLC treatment. This review provides an overview of preclinical and clinical studies that combined RE and radiotherapy for NSCLC treatment. Furthermore, it highlights the ongoing challenges that have to be overcome in order to maximize the benefit; as well as the potential advantage of combinations with particle therapy and immunotherapy, which are rapidly gaining momentum in the treatment landscape of NSCLC. Different angiogenic and immunosuppressive effects are observed between particle therapy and conventional X-ray radiotherapy. The combination of RE, particle therapy and immunotherapy presents a promising future therapeutic triad for NSCLC.

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“…For example, Amano et al developed a nano-sized hyaluronic acid (HA)-based cisplatin-loaded hydrogel, which showed a significant therapeutic effect in both the xenograft and allograft models [ 14 ]. Wang et al proposed a locally injectable endostatin-loaded hydrogel to remodel the tumor microenvironment through anti-angiogenic effects [ 15 ]. These studies underline the potential and feasibility of hydrogels in cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

Temperature-Ion-pH Triple Responsive Gellan Gum as In Situ Hydrogel for Long-Acting Cancer Treatment

Zhou

Zheng

et al. 2022

Gels

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Background: Promising cancer chemotherapy requires the development of suitable drug delivery systems (DDSs). Previous research has indicated that a hydrogel is a powerful DDS for tumor therapy and holds great potential to offer a feasible method for cancer management. Methods: In this study, glutathione-gellan gum conjugate (GSH-GG) was synthesized through chemical reaction. Doxorubicin hydrochloride (DOX) was loaded into GSH-GG to accomplish DOX-loaded GSH-GG. The properties, injectability, drug release, and in vitro and in vivo anticancer effects of DOX-loaded GSH-GG were tested. Results: DOX-loaded GSH-GG showed a temperature-ion dual responsive gelling property with good viscosity, strength, and injectability at an optimized gel concentration of 1.5%. In addition, lower drug release was found under acidic conditions, offering beneficial long-acting drug release in the tumor microenvironment. DOX-loaded GSH-GG presented selective action by exerting substantially higher cytotoxicity on cancer cells (4T1) than on normal epithelial cells (L929), signifying the potential of complete inhibition of tumor progression, without affecting the health quality of the subjects. Conclusions: GSH-GG can be applied as a responsive gelling material for delivering DOX for promising cancer therapy.

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Anti-tumor effect of local injectable hydrogel-loaded endostatin alone and in combination with radiotherapy for lung cancer

Cited by 15 publications

References 41 publications

Injectable Hydrogel as a Unique Platform for Antitumor Therapy Targeting Immunosuppressive Tumor Microenvironment

Injectable Hydrogel as a Unique Platform for Antitumor Therapy Targeting Immunosuppressive Tumor Microenvironment

Recombinant Endostatin as a Potential Radiosensitizer in the Treatment of Non-Small Cell Lung Cancer

Temperature-Ion-pH Triple Responsive Gellan Gum as In Situ Hydrogel for Long-Acting Cancer Treatment

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