Anti-tumor effect of IL-2 and TRAIL expressed by recombinant Salmonella: an immunotherapeutic proposal against bladder cancer by iNOS, Caspases activation and modulation of the immune system
Abstract:IL-2 and TRAIL are therapeutic agents known for their antitumor role, but they can be cleared quickly by the body or be cytotoxic, compromising their function. To reverse this impasse, the synthesis of these agents by live bacteria directly in the tumor is a viable approach, due to bacteria’s preference to colonize tumor tissue. It happens because of the high nutrient grid in this microenvironment and possible escape from the immune system since solid tumors are ischemic and have regions of hypoxia. In this co… Show more
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