Anti-tumor effect of 4-Amino-2-Trifluoromethyl-Phenyl Retinate on human breast cancer MCF-7 cells via up-regulation of retinoid receptor-induced gene-1

A novel retinoic acid analog, 4-amino-2-trifluoromethyl-phenyl retinate, inhibits gastric cancer cell growth

“…In the present study, ATPR inhibited gastric cancer cell growth to a greater extent compared with ATRA. The anti-proliferative effects of ATPR are consistent with those reported in previous in vivo and in vitro studies (24). ATPR reduced the cyclin E level in MKN-74 cells, and altered cell cycle progression in the AGS and MKN-74 cells; however, no such effects were observed following treatment with ATRA.…”

“…In addition to influencing cell growth and apoptosis, RA analogs, including ATPR, can induce cell differentiation in embryonic and adult tissues (1,2,24). Similarly, RA and a number of its analogs inhibit tumor progression by inducing cell differentiation (16), possibly through phosphatidylinositol 3-kinase (PI3K) signaling (35).…”

A Novel All-trans Retinoid Acid Derivative N-(3-trifluoromethyl-phenyl)-Retinamide Inhibits Lung Adenocarcinoma A549 Cell Migration through Down-regulating Expression of Myosin Light Chain Kinase

“…Several researches indicated that ATRA was able to induce morphological differentiation and control cells invasion and migration of many types of tumors (Garattini et al, 2014;Hu et al, 2014b;Zhang et al, 2014a), making it the foremost inducing differentiation therapeutic agent. However, because of its instability and toxicity (Gui et al, 2011;Wang et al, 2013c), ATRA was not applied extensively in clinical except for dermatosis. In the study of our lab, ATPR, a novel derivative of ATRA, with the advantage of lower toxicity and better stability, showed more intense pharmacological action on biological behavior of A549 cells.…”

“…In our previous studies, it was explored that ATPR might inhibit tumor cells migration by down-regulating the expression of MLCK involving p38 signaling pathway (Wang et al, 2013a), one of MAPKs pathway cascade. The mitogen-activated protein kinases (MAPKs) cascades include three classical signal pathways: p38, ERK1/2 and JNK, which play crucial roles in different physiological processes, such as cell growth, apoptosis and inflammatory reaction (Zhu et al, 2012b;2014a;Wang et al, 2013c). It was also reported that the elevation of ERK1/2 might activate the MLCK along with a series of downstream pathways activation (Srinivas et al, 2004;Zhou et al, 2008;Muralidharan-Chari et al, 2009;Zhu et al, 2012b;2014a;Harrison et al, 2013).…”

“…Hence, it is requisite to modify the structure and properties of ATRA to overcome its drawbacks. N-(3-trifluoromethyl-phenyl)-retinamide (ATPR), synthesized by Pharmacy School of Anhui Medical University, is a novel ATRA derivative and has lower toxicity and more powerful effects on both growth and differentiation of A549 cells than ATRA (Chew et al, 2002;Gui et al, 2011;Clemens et al, 2013;Wang et al, 2013c). This may give us a new treatment strategy.…”