Anti-tumor and chemosensitization effects of Cryptotanshinone extracted from Salvia miltiorrhiza Bge. on ovarian cancer cells in vitro

Jiang, Guoqiang; Liu, Jia; Ren, Baoyin; Zhang, Lin; Owusu, Lawrence; Liu, Likun; Zhang, Jing; Tang, Yawei; Li, Weiling

doi:10.1016/j.jep.2017.04.026

Cited by 69 publications

(56 citation statements)

References 35 publications

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“…CT also suppressed the proliferation of prostate cancer cells via the inhibition of JNK/STAT3 signaling pathway . Meanwhile, CT was found to inhibit the proliferation of ovarian cancer cells and sensitize ovarian cancer cells to chemotherapy . In the present study, we demonstrated that CT had the anti‐cancer effects on ovarian cancer cells in a dose‐dependent manner.…”

Section: Discussionsupporting

confidence: 53%

“…Cryptotanshinone (CT) is isolated from the plant Salvia miltiorrhiza Bunge and has been identified to block STAT3 phosphorylation and homodimerization . CT has been demonstrated to have anti‐tumor activities in various malignancies, including breast cancer,liver cancer,prostate cancer, and ovarian cancer . CT was found to induced apoptosis and cell cycle arrest in gastric cancer cells via reactive oxygen species (ROS)‐mediated MAPK and AKT signaling pathways .…”

Section: Introductionmentioning

confidence: 99%

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Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells

et al. 2018

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Ovarian cancer is the most malignant gynecologic cancer among women worldwide. Cryptotanshinone (CT), isolated from Salvia miltiorrhiza Bunge, has been identified as a potential therapeutic agent in treating several malignant tumors, but the molecular mechanism of CT in ovarian cancer still remains illustrated. Here, we sought to elucidate the regulatory function of CT on cell glucose metabolism in ovarian cancer. The treatment of CT on ovarian cancer cells effectively inhibited glucose uptake and lactate production in ovarian cancer cells. The expression levels of glycolysis‐related proteins, such as GLUT1, LDHA, and HK2, were decreased by the treatment of CT detected by qRT‐PCR and immunoblotting. Mechanistically, CT exerted its anti‐tumor effect by targeting STAT3/SIRT3/HIF‐1α signaling pathway in vitro and in vivo, which could be rescued by the introduction of SIRT3 shRNA in ovarian cancer cells. The clinical data showed that the expression level of STAT3 in ovarian cancer patients’ sera and tissues was positively correlated with those of GLUT1, LDHA, HK2 and HIF‐1α, but negatively with that of SIRT3These findings provide evidence that CT inhibited cellular glycolysis‐induced cell growth and proliferation through repression of STAT3/SIRT3/HIF‐1α signaling pathway, indicating that CT may be developed as a chemotherapeutic agent to treat ovarian cancer.

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Section: Discussionsupporting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells

et al. 2018

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“…Considering the chemosensitizing effect, Jiang et al . showed that a quinoid diterpene, cryptotanshinone (isolated from the roots of Salvia miltiorrhiza ) sensitized ovarian cancer cells to cisplatin by inhibiting MMP‐2 and MMP‐9 expression …”

Section: Discussionmentioning

confidence: 99%

“…The literature reports some chemosensitizing effects of some compounds isolated from natural sources in association with chemotherapeutic agents: Cryptotanshinone, a diterpenoid extracted from Salvia miltiorrhiza, could sensitize A2780 ovarian cancer cells to cisplatin treatment. [10] The glycoalkaloid solamargine increased the susceptibility of breast cancer cells to cisplatin. [27] A low dose of the benzylisoquinoline alkaloid noscapine acted as a chemosensitizer for docetaxel on triple negative breast cancer cells.…”

Section: Discussionmentioning

confidence: 99%

“…Such efforts are motivated by their chemosensitizing or synergetic/additive effects against malignant tumors . In this context, bioactive compounds from natural products have been explored to act as potent chemosensitizer in combination with conventional chemotherapeutic drugs . This strategy can offer several benefits such as overcoming limitations with existing chemotherapeutic regimes by reducing the dosage required and consequently, the side effects of the chemosensitizing agent used.…”

Section: Introductionmentioning

confidence: 99%

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Chemosensitizing Effect of Cernumidine Extracted from Solanum cernuum on Bladder Cancer Cells in Vitro

Miranda

Mondal

Singh

et al. 2019

Chemistry & Biodiversity

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Cernumidine (CER) is a guanidinic alkaloid isolated from Solanum cernuum leaves. In this work, we investigated the cytotoxicity, chemosensitizing effect of cernumidine to cisplatin (cDDP) and the possible mechanism of action of the combination on bladder cancer cells. Cernumidine showed cytotoxicity and could sensitize bladder cancer cells to cisplatin. The combination of CER+cDDP inhibited cell migration on T24 cells. CER+cDDP down‐regulated MMP‐2/9 and p‐ERK1/2, while it increased EGFR activity corroborating the observed cell migration inhibition. Down‐regulation of Bcl‐2 and up‐regulation pro‐apoptotic Bax and further depletion of the mitochondrial membrane potential (ΔΨm) indicates that mitochondria play a central role in the combination treatment inducing the mitochondrial signaling pathway of apoptosis in T24 cells. Our data showed that the alkaloid cernumidine is worthy of further studies as a chemosensitizing agent to be used in complementary chemotherapy.

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Qualitative and quantitative determination of YiXinShu Tablet using ultra high performance liquid chromatography with Q Exactive hybrid quadrupole orbitrap high-resolution accurate mass spectrometry

Sun

Zuo

et al. 2017

J. Sep. Sci.

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To clarify and quantify the chemical profile of YiXinShu Tablet rapidly, a feasible and accurate strategy was developed by applying ultra high performance liquid chromatography with Q Exactive hybrid quadrupole orbitrap high-resolution accurate mass spectrometry. A total of 105 components were identified, including 25 phenanthraquinones, 11 lactones, 19 lignans, 24 acids, and 26 other compounds. Among them, 26 major compounds were unambiguously detected by comparing with reference standards. And 19 of these compounds in three batches of YiXinShu Tablet were selected for quantitative determination. (Z)-Ligustilide, salvianic acid A, salvianolic acid A, salvianolic acid B, and rosmarinic acid were abundant in these three batches with contents over 1 mg/g. The established analysis methods were examined to be accurate and feasible. The results show that the ultra high performance liquid chromatography with Q Exactive hybrid quadrupole orbitrap high-resolution accurate mass spectrometry method has a powerful qualitative ability and promising quantitative application.

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Anti-tumor and chemosensitization effects of Cryptotanshinone extracted from Salvia miltiorrhiza Bge. on ovarian cancer cells in vitro

Cited by 69 publications

References 35 publications

Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells

Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells

Chemosensitizing Effect of Cernumidine Extracted from Solanum cernuum on Bladder Cancer Cells in Vitro

Qualitative and quantitative determination of YiXinShu Tablet using ultra high performance liquid chromatography with Q Exactive hybrid quadrupole orbitrap high-resolution accurate mass spectrometry

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