Anti-tumor alkaloids from Peganum harmala

Zhang, Qin; Zan, Yan-Hui; Yang, Hangao; Yang, Mu; Liu, Fang-Shen; Li, Sheng-Ge; Peng, Xiaohui; Lin, Bin; Li, Zhan‐Lin; Li, Dahong; Hua, Hui‐Ming

doi:10.1016/j.phytochem.2022.113107

Cited by 13 publications

(4 citation statements)

References 28 publications

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“…Based on the high salt tolerance, reclamation potential, and medicinal value of P. harmala [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ], this study investigated the germination responses of its seeds to various environmental factors, including light, temperature, drought, and salinity. Our findings suggest that P. harmala is sensitive to temperature, light, drought, and salinity.…”

Section: Discussionmentioning

confidence: 99%

Seed Germination Ecology of the Medicinal Plant Peganum harmala (Zygophyllaceae)

Yan

Tanveer

et al. 2023

Plants

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Seed germination is a crucial stage in the life cycle of annuals in arid, saline regions and is particularly vulnerable to abiotic stresses. Peganum harmala, a valuable medicinal plant, has limited research on its seed germination response to different environmental stresses in the arid, saline regions of Central Asia. To investigate this, we studied the effects of various temperature regimes (ranging from 20/5 to 35/20 °C), light exposure (12 hours light/12 hours dark and continuous dark), seven levels of polyethylene glycol (PEG-6000) concentration (ranging from 0–30%), and four types of salinity (ranging from 0–600 mmol L−1). Our findings show that photoperiod and temperature significantly influence germination. Optimal temperature range for seed germination was observed at 30/15 °C, with simulated critical and limit values of drought tolerance being highest (17.30% and 24.98%). However, higher temperatures (35/20 °C) and lower temperatures (20/5 °C) reduced the critical and limit values of drought tolerance. Additionally, the type and concentration of salinity had a significant effect on the seed germination, shoot, and root lengths of P. harmala. Regression analysis indicated that the critical values of NaCl, Na2SO4, NaHCO3, and Na2CO3 tolerance during germination were 178 mmol L−1, 101 mmol L−1, 106 mmol L−1, and 54 mmol L−1, respectively. Salinity inhibition on seed germination followed the order: NaCl < NaHCO3 < Na2SO4 < Na2CO3. Moreover, NaCl, Na2SO4, NaHCO3, and Na2CO3 significantly inhibited the growth of P. harmala seedlings in both shoots and roots. Our study demonstrates the sensitivity of P. harmala to environmental factors such as light, temperature, drought, and salinity. The study provides valuable information on the germination ecology of P. harmala under diverse ecological scenarios, which can be useful in developing efficient propagation and utilization of this medicinal plant.

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Section: Discussionmentioning

confidence: 99%

Seed Germination Ecology of the Medicinal Plant Peganum harmala (Zygophyllaceae)

Yan

Tanveer

et al. 2023

Plants

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“…As of 2019, approximately 25% of all newly approved anticancer drugs were naturally derived. Natural alkaloids with significant medicinal value are expected to play key roles in cancer treatment in the foreseeable future ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Research progress on the antitumor effects of harmine

Hu,

Yu,

Yang

et al. 2024

Front. Oncol.

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Harmine is a naturally occurring β-carboline alkaloid originally isolated from Peganum harmala. As a major active component, harmine exhibits a broad spectrum of pharmacological properties, particularly remarkable antitumor effects. Recent mechanistic studies have shown that harmine can inhibit cancer cell proliferation and metastasis through epithelial-to-mesenchymal transition, cell cycle regulation, angiogenesis, and the induction of tumor cell apoptosis. Furthermore, harmine reduces drug resistance when used in combination with chemotherapeutic drugs. Despite its remarkable antitumor activity, the application of harmine is limited by its poor solubility and toxic side effects, particularly neurotoxicity. Novel harmine derivatives have demonstrated strong clinical application prospects, but further validation based on drug activity, acute toxicity, and other aspects is necessary. Here, we present a review of recent research on the action mechanism of harmine in cancer treatment and the development of its derivatives, providing new insights into its potential clinical applications and strategies for mitigating its toxicity while enhancing its efficacy.

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“…In addition, the extract has anti-hallucination, anti-excitation, and anti-depression activities [ 30 ]. These active alkaloids have antitumor activity owing to their anti-proliferative effects that reduce the growth of colon cancer cells [ 31 , 32 ]. Other bioactive properties of the harmal extract include its application as an efficient antimicrobial and antibacterial agent against several types of bacteria, such as Proteus vulgaris and Bacillus subtilis [ 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

An Integrated Experimental and Theoretical Studies on the Corrosion Inhibition of Carbon Steel by Harmal Extracts

Hammud

Maache²,

Otaibi

et al. 2022

Molecules

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The corrosion inhibition effect of the three extracts from Harmal roots (HRE), leaves (HLE), and flowers (HFE) were studied for carbon steel corrosion inhibition in 0.25 M H2SO4 solution. The electrochemical impedance study indicated that the three types of extracts decreased corrosion effectively through a charge transfer mechanism. Harmal roots and leaf extracts showed inhibition values of 94.1% and 94.2%, while it was 88.7% for Harmal flower extract at the inhibitor concentration of 82.6 ppm. Potentiodynamic polarization data revealed that Harmal extracts acted through predominant cathodic type inhibition. Both the corrosion current density and corrosion rate decreased significantly in the presence of Harmal extracts compared to blank solution. The corrosion rate (mpy) value was 63.3, 86.1, and 180.7 for HRE, HLE, and HFE, respectively. The adsorption-free energy change ΔGads (kJ·mol−1) values calculated from the Langmuir adsorption isotherm plots were for HRE (−35.08), HLE (−33.17), and HFE (−33.12). Thus, corrosion inhibition occurred due to the adsorption of Harmal extract on the carbon steel surface via the chemisorption mechanism. Moreover, a computational investigation using B3LYP/6-311G++(d,p) basis set in both gaseous and aqueous phases was performed for the major alkaloids (1–8) present in the Harmal extract.

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Anti-tumor alkaloids from Peganum harmala

Cited by 13 publications

References 28 publications

Seed Germination Ecology of the Medicinal Plant Peganum harmala (Zygophyllaceae)

Seed Germination Ecology of the Medicinal Plant Peganum harmala (Zygophyllaceae)

Research progress on the antitumor effects of harmine

An Integrated Experimental and Theoretical Studies on the Corrosion Inhibition of Carbon Steel by Harmal Extracts

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