Anti-tumor activity of the farnesyl-protein transferase inhibitors arteminolides, isolated from Artemisa

Lee, Seung Ho; Lee, Mi-Young; Kang, Hyun-Mi; Han, Dong Cho; Son, Kwang‐Hee; Yang, Deok Cho; Sung, Nack‐Do; Lee, Chang Woo; Kim, Hwan Mook; Kwon, Byoung‐Mog

doi:10.1016/j.bmc.2003.08.008

Cited by 53 publications

(26 citation statements)

References 13 publications

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“…The genus Artemisia, one of the largest genera belonging to the Compositae family consisting of more than 350 species, is predominantly distributed in the world (21,26). Artemisia species are frequently utilized for the treatment of diseases such as inflammation, hepatitis, cancer, and infections by malaria, fungi, bacteria, and viruses (8,10,18,20,22,26). A. iwayomogi KITAMURA.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Antibacterial Activity Against Oral Bacteria by the Essential Oil of Artemisia iwayomogi

Cha

2007

J Bacteriol Virol

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Section: Introductionmentioning

confidence: 99%

Chemical Composition and Antibacterial Activity Against Oral Bacteria by the Essential Oil of Artemisia iwayomogi

Cha

2007

J Bacteriol Virol

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“…In the past decades, several natural compounds have shown a great promise in treatment of cancer and numerous natural compounds of dietary and botanical origin has been identified with chemotherapeutic and chemopreventive potential (Amin et al, 2009;Kintzios and Barberaki, 2004). Plants-derived natural compounds possess a variety of biological activities and draw considerable attention in pharmacological research due to their anti-inflammatory, anti-malarial, anti-hepatitis, and anti-cancer activities (Khan et al, 2012;Lee et al, 2003;Tan et al, 1998). As novel therapeutic agents and treatment approaches are desired to improve the clinical outcome.…”

Section: Introductionmentioning

confidence: 99%

Tubeimoside-1 upregulates p21 expression and induces apoptosis and G2/M phase cell cycle arrest in human bladder cancer T24 cells

Rasul

Shen

Wang

et al. 2014

Bangladesh J Pharmacol

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Tubeimoside-1 (TBMS1) is a triterpenoid saponin with potent anticancer properties. In this study, for the first, we examined the anti-proliferative effects of TBMS1 in human bladder cancer T24 cells and its ability to induce apoptosis and cell cycle arrest. Our results demonstrated that TBMS1 decreased the cell viability of bladder cancer T24 cells in a dose-dependent manner. Flow cytometric analysis showed that TBMS1 significantly triggered apoptosis in T24 cells and arrested cell cycle at G2/M phase in a dosedependent manner. Further characterization demonstrated that TBMS1-induced apoptosis is associated with dissipation in mitochondrial membrane potential (ΔΨm), down-regulation of Bcl-2, and up-regulation of Bax and p21 in TBMS1-treated T24 cells. These in vitro results suggested that TBMS1 is an effective anti-bladder cancer natural compound that worth further mechanistic and therapeutic studies in human bladder cancer. Article InfoReceived:12 which is regulated by down-regulation of Bcl-2 and upregulation of Bax and p21. This study will pave the way for further in vivo studies of this potent anti-bladder cancer compounds. Material and Methods Chemicals and reagents:Cell culture medium reagents and MTT [3′-(4, 5 dimethyl-thiazol-2-yl)-2, 5-diphenyl tetrazolium bromide], propidium iodide (PI), and dimethyl sulfoxide (DMSO) were purchased from Sigma. Fetal bovine serum (FBS) was purchased from the Hangzhou Sijiqing Biological Engineering Materials Co., Ltd. Annexin V-FITC apoptosis detection kit was purchased from Beyotime Institute of Biotechnology Shanghai, China. Rabbit polyclonal anti-human Bcl-2, Bax, and p21 antibodies were purchased from Wuhan Boster Biological Technology Co., Ltd. β-actin, antimouse and anti-rabbit antibodies were purchased from Santa Cruz Biotechnology. Ponceou and cell lysis buffer for Western and IP were purchased from Bio SS Beijing. Rhodamine 123 was purchased from Eugene Co. (Oregon, U.S.A.).Cell culture: Human bladder cancer cell line (T24) was purchased from the Cell Bank of Shanghai Institute of Cell Biology, Chinese Academy of Sciences (Shanghai, China). The cells were cultured in DMEM supplemented with 10% FBS and 100 unit of Penicillin at 37℃ in a CO2 incubator with 5% CO2, 95% air and 100% humidity. Cells were plated in 10 cm culture dish and allowed to grow to approximately 70% confluence before experimentation.

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“…Artemisia plants possess a variety of biological activities and draw considerable attention in pharmacological research due to their anti-inflammatory, anti-malarial, anti-hepatitis, and anti-cancer activities (Khan et al, 2012;Lee et al, 2003;Tan et al, 1998). Jaceosidin (Figure 1), isolated from Artemesia argyi, has been reported to have promising biological effects, including anti-tumorigenic, antioxidant, and anti-inflammatory activities (Khan et al, 2012;Kim et al, 2008;Min et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Jaceosidin inhibits proliferation of human bladder cancer T24 cells through induction of cell cycle arrest and apoptosis

Yong

Tan

2013

Bangladesh J Pharmacol

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Jaceosidin, isolated from Artemesia argyi, has been shown to possess promising anti-cancer potential against various cancer cells. However, its effect against bladder cancer cells remained unknown. In this study, for the first time, we investigated the effects of jaceosidin on cell proliferation, cell cycle, and apoptosis in bladder cancer T24 cells by using MTT assay and flow cytometric analysis. The results revealed that jaceosidin decreased the cell viability of bladder cancer T24 cells in a dose-and time-dependent manner. Flow cytometric analysis demonstrated that jaceosidin significantly triggered apoptosis in T24 cells and arrested cell cycle at G2/M phase in a timedependent manner. Further characterization showed that jaceosidin-induced apoptosis is associated with dissipation in mitochondrial membrane potential (ΔΨm), up-regulation of Bax and down-regulation of Bcl-2 in jaceosidintreated T24 cells. These in vitro results suggested that jaceosidin should be further examined for in vivo activity and molecular mechanism in human bladder cancer. Article Info

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Anti-tumor activity of the farnesyl-protein transferase inhibitors arteminolides, isolated from Artemisa

Cited by 53 publications

References 13 publications

Chemical Composition and Antibacterial Activity Against Oral Bacteria by the Essential Oil of Artemisia iwayomogi

Chemical Composition and Antibacterial Activity Against Oral Bacteria by the Essential Oil of Artemisia iwayomogi

Tubeimoside-1 upregulates p21 expression and induces apoptosis and G2/M phase cell cycle arrest in human bladder cancer T24 cells

Jaceosidin inhibits proliferation of human bladder cancer T24 cells through induction of cell cycle arrest and apoptosis

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