Anti-tumor activity evaluation of novel chrysin–organogermanium(IV) complex in MCF-7 cells

Yang, Fen; Jin, Hua; Pi, Jiang; Jiang, Jie; Liu, Li; Bai, Han; Yang, Peihui; Cai, Jiye

doi:10.1016/j.bmcl.2013.08.055

Cited by 53 publications

(25 citation statements)

References 38 publications

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“…The anti-carcinogenic activity of chrysin has been reported by numerous studies [16][17][18]20,21]. A number of molecular pathways contribute to the anticancer property of chrysin, such as sensitizing TNFa-mediated apoptosis by inhibiting NFjB activation [20], or reducing Nrf2 expression through down-regulating PI3K-Akt and the ERK pathway to reverse doxorubicin resistance [36].…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that chrysin (5,7-dihydroxyflavone), a flavone commonly found in various plants and foods, had strong anti-inflammation [11] and antioxidative [12] properties. In addition, chrysin exhibited anti-cancer activity in a diverse range of human [13][14][15][16][17][18] and animal derived cells [19]. However, the underlying mechanisms of the anti-cancer property of chrysin are not fully understood.…”

Section: Introductionmentioning

confidence: 99%

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Combination of chrysin and cisplatin promotes the apoptosis of Hep G2 cells by up-regulating p53

Huang²,

Wang

et al. 2015

Chemico-Biological Interactions

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Combination of chrysin and cisplatin promotes the apoptosis of Hep G2 cells by up-regulating p53

Huang²,

Wang

et al. 2015

Chemico-Biological Interactions

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“…Previous studies have suggested that chrysin possesses antioxidant (8), antihypertensive (9), antidiabetogenic (10) and anxiolytic properties (11). In addition, chrysin exerts a strong anticancer effect in multiple types of human cancer, since it induces cell cycle arrest and cell apoptosis (12); however, whether chrysin may be used as a novel antitumor drug against HCC has not been extensively investigated.…”

Section: Introductionmentioning

confidence: 99%

Chrysin induces cell apoptosis via activation of the p53/Bcl-2/caspase-9 pathway in hepatocellular carcinoma cells

Zhang

Liu

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Chrysin is a major active ingredient of flavonoids, known to exhibit protective effects against various types of cancer. However, the anticancer role of chrysin against hepatocellular carcinoma (HCC) and the underlying molecular mechanisms remain unclear. In order to evaluate the effects of chrysin on cell viability and apoptosis in human HCC, HepG2 and QGY7701 cells were used in the present study. Cell viability was monitored using an MTT assay. In addition, an Annexin V-fluorescein isothiocyanate/propidium iodide kit was used for the labeling of the apoptotic cells, which were then measured using flow cytometry. Western blotting was used to examine the protein expression of p53, B-cell lymphoma-2 (Bcl-2), Bcl-2-associated X (Bax), Bcl-2-associated death promoter (Bad), Bcl-2 homologous antagonist/killer (Bak), caspases-3 and -9, and cleaved-caspases-3 and -9. The results of the present study revealed that chrysin suppressed the cell viability of HepG2 and QGY7701 cells in a concentration-dependent manner. In addition, chrysin induced significant apoptosis in HepG2 and QGY7701 cells. Furthermore, it was demonstrated that chrysin treatment increased the expression of proapoptotic proteins, including p53, Bax, Bad and Bak, while it decreased the protein level of antiapoptotic protein Bcl-2. It was also demonstrated that chrysin induced apoptosis in the HCC cells by regulating the p53/Bcl-2/caspase-9 signaling pathway. In conclusion, the results of the present study suggested that chrysin may be a potential candidate agent for the induction of cell apoptosis in human HCC.

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“…Recently, antitumor properties of propolis, the most remarkable activity, have been widely documented in various culture cell lines such as human leukemia (HL-60, CI41, U937), human colon cancer cells (SW480, HCT116), human cervical cancer (ME180, Hela), human glioblastoma cells (U87MG), human lung carcinoma (A549), human hepatocellular carcinoma (HepG2, SNU449), human pancreatic cancer (PANC-1, BxPC-3) cells, and mammary carcinoma (MCF-7) [6–15]. However, the molecular mechanisms of Chinese propolis on antitumor effects have not been fully elucidated and need to be deeply clarified.…”

Section: Introductionmentioning

confidence: 99%

Antitumor Activity of Chinese Propolis in Human Breast Cancer MCF-7 and MDA-MB-231 Cells

Han

Yan

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Chinese propolis has been reported to possess various biological activities such as antitumor. In present study, anticancer activity of ethanol extract of Chinese propolis (EECP) at 25, 50, 100, and 200 μg/mL was explored by testing the cytotoxicity in MCF-7 (human breast cancer ER(+)) and MDA-MB-231 (human breast cancer ER(−)) cells. EECP revealed a dose- and time-dependent cytotoxic effect. Furthermore, annexin A7 (ANXA7), p53, nuclear factor-κB p65 (NF-κB p65), reactive oxygen species (ROS) levels, and mitochondrial membrane potential were investigated. Our data indicated that treatment of EECP for 24 and 48 h induced both cells apoptosis obviously. Exposure to EECP significantly increased ANXA7 expression and ROS level, and NF-κB p65 level and mitochondrial membrane potential were depressed by EECP dramatically. The effects of EECP on p53 level were different in MCF-7 and MDA-MB-231 cells, which indicated that EECP exerted its antitumor effects in MCF-7 and MDA-MB-231 cells by inducing apoptosis, regulating the levels of ANXA7, p53, and NF-κB p65, upregulating intracellular ROS, and decreasing mitochondrial membrane potential. Interestingly, EECP had little or small cytotoxicity on normal human umbilical vein endothelial cells (HUVECs). These results suggest that EECP is a potential alternative agent on breast cancer treatment.

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Anti-tumor activity evaluation of novel chrysin–organogermanium(IV) complex in MCF-7 cells

Cited by 53 publications

References 38 publications

Combination of chrysin and cisplatin promotes the apoptosis of Hep G2 cells by up-regulating p53

Combination of chrysin and cisplatin promotes the apoptosis of Hep G2 cells by up-regulating p53

Chrysin induces cell apoptosis via activation of the p53/Bcl-2/caspase-9 pathway in hepatocellular carcinoma cells

Antitumor Activity of Chinese Propolis in Human Breast Cancer MCF-7 and MDA-MB-231 Cells

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