Anti-tumor activities and apoptosis-regulated mechanisms of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice

Abstract

Bufalin has significant anti-tumor activities in the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice with no marked toxicity and was able to induce apoptosis of transplanted tumor cells. This apoptosis may be mediated mainly via up-regulating the expression of apoptosis-regulated gene bax, which may be involved in its anti-tumor mechanism of bufalin.

Characterization and Resistance Mechanisms of A 5-fluorouracil-resistant Hepatocellular Carcinoma Cell Line

“…The ratio of Bcl-2/Bax is a critical determinant for cell apoptosis. In our previous study, a loss of Bcl-2 expression was found in BEL-7402 cells (Han et al, 2007). Therefore, the expression of Bcl-xl instead of Bcl-2 was examined combined with Bax, and the ratio of Bcl-xl/ Bax were analyzed in this study.…”

Bufalin, a Traditional Oriental Medicine, Induces Apoptosis in Human Cancer Cells

“…Bufalin has significant anti-tumor activities in the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice with no marked toxicity and was able to induce apoptosis of transplanted tumor cells. This apoptosis may be mediated mainly via up-regulating the expression of apoptosisregulated gene bax, which may be involved in its anti- tumor mechanism of bufalin (Han et al, 2007).…”

Three Bufadienolides-Induced Human Lung Cancer CL1-5 Cell Death Mainly through Autophagy

“…Bufalin induced autophagy through Akt/mTOR pathway and apoptosis in liver cancer SK-HEP-1 cells [9]. In vivo examination of anti-human hepatocellular carcinoma in nude mice, bufalin exhibited a tumor inhibitory effect [10].…”