Anti-tuberculosis activity and its structure-activity relationship (SAR) studies of oxadiazole derivatives: A key review

Verma, Santosh Kumar; Verma, Rameshwari; Verma, Shekhar; Vaishnav, Yogesh; Tiwari, S.P.; Rakesh, K.P.

doi:10.1016/j.ejmech.2020.112886

Cited by 55 publications

(31 citation statements)

References 84 publications

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“…Oxadiazoles possess a broad range of therapeutic applications [ 197 ]. Besides this, these privileged scaffolds display a broad array of biological applications such as anti-viral, anti-bacterial, anti-tuberculosis, anti-cancer, anti-HIV, anti-convulsant, analgesics, pesticide, and so on [ [198] , [199] , [200] , [201] ].…”

Section: Mixed Heterocyclic Scaffoldsmentioning

confidence: 99%

Seeking heterocyclic scaffolds as antivirals against dengue virus

Aamna²,

Sahu³

et al. 2022

European Journal of Medicinal Chemistry

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Section: Mixed Heterocyclic Scaffoldsmentioning

confidence: 99%

Seeking heterocyclic scaffolds as antivirals against dengue virus

Aamna²,

Sahu³

et al. 2022

European Journal of Medicinal Chemistry

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“…Tuberculosis is an infectious disease that has existed for thousands of years and is still a major threat to human health. [ 148 ] When acrylonitrile‐based compounds with antimycobacterial activity are examined, benzotriazole, benzothiazole, benzimidazole, and imidazole rings are observed frequently in their molecular structures.…”

Section: Biological Activities Of Acrylonitrilesmentioning

confidence: 99%

Insights into the chemistry and therapeutic potential of acrylonitrile derivatives

Tan

Zengin

2021

Archiv der Pharmazie

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Acrylonitrile is a fascinating scaffold widely found in many natural products, drugs, and drug candidates with various biological activities. Several drug molecules such as entacapone, rilpivirine, teriflunomide, and so forth, bearing an acrylonitrile moiety have been marketed. In this review, diverse synthetic strategies for constructing desired acrylonitriles are discussed, and the different biological activities and medicinal significance of various acrylonitrile derivatives are critically evaluated. The information gathered is expected to provide rational guidance for the development of clinically useful agents from acrylonitriles.

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“…The presence of oxadiazole moiety is required for producing biological activities like antibacterial, antifungal, anticancer, antitubercular, antioxidant, analgesic and antiinflammatory, etc. [68].…”

Section: Structure-activity Relationship (Sar) Studymentioning

confidence: 99%

Green Synthetic Approach: An Efficient Eco-Friendly Tool for Synthesis of Biologically Active Oxadiazole Derivatives

et al. 2021

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Green synthetic protocol refers to the development of processes for the sustainable production of chemicals and materials. For the synthesis of various biologically active compounds, energy-efficient and environmentally benign processes are applied, such as microwave irradiation technology, ultrasound-mediated synthesis, photo-catalysis (ultraviolet, visible and infrared irradiation), molecular sieving, grinding and milling techniques, etc. Thesemethods are considered sustainable technology and become valuable green protocol to synthesize new drug molecules as theyprovidenumerous benefits over conventional synthetic methods.Based on this concept, oxadiazole derivatives are synthesized under microwave irradiation technique to reduce the formation of byproduct so that the product yield can be increased quantitatively in less reaction time. Hence, the synthesis of drug molecules under microwave irradiation follows a green chemistry approach that employs a set of principles to minimize or remove the utilization and production of hazardous toxic materials during the design, manufacture and application of chemical substances.This approach plays a major role in controlling environmental pollution by utilizing safer solvents, catalysts, suitable reaction conditions and thereby increases the atom economy and energy efficiency. Oxadiazole is a five-membered heterocyclic compound that possesses one oxygen and two nitrogen atoms in the ring system.Oxadiazole moiety is drawing considerable interest for the development of new drug candidates with potential therapeutic activities including antibacterial, antifungal, antiviral, anticonvulsant, anticancer, antimalarial, antitubercular, anti-asthmatic, antidepressant, antidiabetic, antioxidant, antiparkinsonian, analgesic and antiinflammatory, etc. This review focuses on different synthetic approaches of oxadiazole derivatives under microwave heating method and study of their various biological activities.

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Anti-tuberculosis activity and its structure-activity relationship (SAR) studies of oxadiazole derivatives: A key review

Cited by 55 publications

References 84 publications

Seeking heterocyclic scaffolds as antivirals against dengue virus

Seeking heterocyclic scaffolds as antivirals against dengue virus

Insights into the chemistry and therapeutic potential of acrylonitrile derivatives

Green Synthetic Approach: An Efficient Eco-Friendly Tool for Synthesis of Biologically Active Oxadiazole Derivatives

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