Anti-Tubercular Activities and Molecular Characterization of Salivary Extract of Leech (&amp;lt;i&amp;gt;Hirudo medicinalis&amp;lt;/i&amp;gt;) against &amp;lt;i&amp;gt;Mycobacterium tuberculosis&amp;lt;/i&amp;gt;

Ojo, Praise Olufunmilola; Babayi, Hausatu; Olayemi, Israel Kayode; Peter, Oladosun Oluwale; Fadipe, Labake Ajoke; Baba, Elisha; Izebe, Kasim

doi:10.4236/jtr.2018.61001

Cited by 4 publications

(2 citation statements)

References 9 publications

(8 reference statements)

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“…This mainly depends on the ingestion of a medicinal leech substance -destabilase. Among the world's major diseases, their positive effect on cancer cells and cancer therapy has been proven now, which may be due to the effect on them of biologically active substances of eglin, which prevent division and destroy cancer pain and cancer cells (Kalender et al, 2010;Shakouri et al, 2018), Mycobacterium tuberculosis (Ojo et al, 2018). Their action has also been proven in various diseases of a non-infectious nature.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2022

JJBS

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Study areas include cell biology, genomics, microbiology, immunology, molecular biology, biochemistry, embryology, immunogenetics, cell a n d tissue culture, molecular ecology, genetic engineering and biological engineering, bioremediation and biodegradation, bioinformatics, biotechnology regulations, gene therapy, organismal biology, microbial and environmental biotechnology, marine sciences. The JJBS welcomes the submission of manuscripts that meet the general criteria of significance and academic excellence. All articles published in JJBS are peerreviewed. Papers will be published approximately in one to two months after acceptance.

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Section: Introductionmentioning

confidence: 99%

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2022

JJBS

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Section: Introductionmentioning

confidence: 99%

The Effect of the Biologically Complex of a Medical Leech Active Substances on The Immunosuppressive State of Rats

2022

JJBS

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The course of all infectious diseases largely depends on immunity. An organism with a weak immune system gives up faster before diseases. Also, the number of immunodeficiencies with various etiologies has increased. Therefore, scientists are looking for various methods of dealing with these diseases. One such method is hirudotherapy using medicinal leeches, which has many therapeutic effects. As a result, the study of animals with a chemically immunosuppressive state has become relevant. The experiment was carried out on 45 mature male nonlinear rats with a body weight of 360-370 g. To simulate immunosuppression in experimental groups of animals, we used "Endoxan". It was administered intraperitoneally to mature rats after the formation of 3 study groups: 1) control -without intervention; 2) "Endoxan" at a dose of 100 mg / kg; 3) "Endoxan" at a dose of 100 mg / kg + water-salt extract of Hirudo verbanа. After 3 weeks, the animals were measured for weight and body length, and were decapitated. Blood was taken with the addition of an anticoagulant. Then the total number of erythrocytes and leukocytes, the relative blood leukocyte formula, the mass and morphology of the thymus, the weight of the spleen and liver were examined. As a result, in the second and third groups, all indicators decreased, which indicates the immunosuppressive effect of the drug. After the introduction of the water-salt extract in the third group, the indicators increased (in some respects, even more) in comparison with the control group.

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Evaluation of Mitotic Activity of Bone Marrow Under Short-Term Hypothermia

Aminov¹,

Frolov²,

Aminova³

et al. 2022

Probl Cryobiol Cryomed

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In this research, we have studied the mitotic activity of bone marrow when applying medicinal leeches and short-term hypothermia. The bone marrow mitotic indices were compared within an immediate examination of the thigh removed from the body and during a short-term hypothermia. As a result, no statistical differences were found between the mitotic levels during immediate examination and a short-term hypothermia in the intact animals and those after medicinal leech application, that evidenced to a hypothermal fixation of initial level of this index, preservation of biomembrane physiological state prior to hypotonic stress and cell morphology. The used here short-term hypothermia on bone marrow cells may be included in the multi-profile algorithm of laboratory analysis when studying a mitotic index in actively proliferating cells.

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Anti-Tubercular Activities and Molecular Characterization of Salivary Extract of Leech (<i>Hirudo medicinalis</i>) against <i>Mycobacterium tuberculosis</i>

Cited by 4 publications

References 9 publications

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The Effect of the Biologically Complex of a Medical Leech Active Substances on The Immunosuppressive State of Rats

Evaluation of Mitotic Activity of Bone Marrow Under Short-Term Hypothermia

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