Anti-Trypanosoma cruzi antibody detection in blood donors in the Southern Brazil

Araújo, Anelise Bergmann; Vianna, Élvia Elena Silveira; Berne, M. E. A.

doi:10.1590/s1413-86702008000600007

Cited by 18 publications

(22 citation statements)

References 19 publications

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“…Os demais estudos referem-se à prevalência da doença entre doações, variando no Brasil entre 0,1 e 0,3%, segundo os trabalhos mais recentes 11,12,13,14,15,16 . O relatório de produção hemoterápica brasileira, com dados de 2013, indica 0,34% de doações reagentes para a doença de Chagas na triagem entre os doadores, com os maiores percentuais (0,5%) no Nordeste e Sudeste 17 .…”

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Prevalência da doença de Chagas entre doadores de sangue do Estado do Piauí, Brasil, no período de 2004 a 2013

2018

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Despite the decline in prevalence of Chagas disease in Brazil, the Northeast region of the country has favorable conditions for its resurgence. The study aimed to analyze positive Chagas disease serology rates among blood donors in Piauí State from 2004 to 2013. Prevalence of positive Chagas disease serology in blood donor screening was 1%, ranging from 0.4% in the Uruçuí Regional Health District to 2.4% in the São Raimundo Nonato Regional Health District. Of the state's 220 municipalities, 58.6% reported cases. Only 34.5% of the positive samples in screening were referred for complementary tests, and 84.4% of these showed negative results. Our findings suggest the possibility of persistent vector-borne transmission in areas of Piauí State and the need for measures to improve complementary testing in positive cases detected by screening.

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Section: Discussionunclassified

Prevalência da doença de Chagas entre doadores de sangue do Estado do Piauí, Brasil, no período de 2004 a 2013

2018

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“…Compared to the rest of Brazil, the obtained anti-T. cruzi Ab seroprevalence in blood donors can be regarded as low. Brazilian blood donors from various regions demonstrate anti-T. cruzi Ab prevalences of 0.47% (southern Brazil) [12], 1.4% (Londrina city, Paraná State) [13], 1.7% (Rio de Janeiro city) [14], and 1.9% (Iguatu city, Ceará State) [15]. The significant difference of the anti-T. cruzi prevalence between blood donors in the different Brazilian regions is probably due to the different sensitivity and specificity of the tests used for the blood donor screening, the year studied, the demographic characteristics of the population, the sample volume, and/or presence of vector transmission.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Trypanosoma Cruzi antibodies in blood donors from the Sao Paulo State, Brazil, between 2012 and 2014

Slavov

Otaguiri

Pinto

et al. 2017

J Infect Dev Ctries

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Introduction: American tripanosomiasis (Chagas disease), the second most neglected disease in the world, is caused by the protozoan parasite Trypanosoma cruzi. Though natural transmission by insect vectors has been controlled, there is significant risk of T. cruzi transmission by blood transfusion in non-endemic regions, generally due to immigration processes from endemic areas. Methodology: The objective of this study was to evaluate anti-T. cruzi seroprevalence in blood donors from the western part of São Paulo State, Brazil, by serologic and immunofluorescence confirmation tests for the period between 2012 and 2014. Currently, this region is regarded as a non-endemic area for Chagas disease. Results: The confirmed overall T. cruzi seroprevalence among blood donors was 0.10%, which can be considered low compared to other Brazilian regions. Nevertheless, the distribution of the anti-T. cruzi antibodies within the examined region was uneven, and some areas of significantly higher prevalence were observed. Conclusions: We could consider two tendencies in the prevalence of T. cruzi: (i) residual older undiagnosed cases from São Paulo State, and (ii) immigration from endemic Brazilian or South American regions. The discordance obtained for T. cruzi prevalence by serologic and immunofluorescence methods demonstrates that more specific routine diagnosis is needed to diminish the cost of the assays and the loss of blood supply once all seropositive blood bags are immediately discarded.

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“…Nevertheless, algorithms were developed and are considered to be appropriate to rule out the risk of Chagas disease transmission through blood products [8][9][10][11]. However, the main concerns of blood banks screening are to rule out disease in blood products and to deal with indeterminate and false-positive results after serological screening.…”

Section: Discussionmentioning

confidence: 99%

Dealing with initial inconclusive serological results for chronic Chagas disease in clinical practice

Lapa

Saraiva

Hasslocher‐Moreno

et al. 2011

Eur J Clin Microbiol Infect Dis

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Most guidelines for Chagas disease recommend the performance of two serological tests in order to detect it. However, inconclusive results may arise from this strategy. The aim was to describe whether serological follow-up together with the patient's clinical characteristics could clarify the outcome of patients with initial inconclusive test results. In this retrospective case series, all results of Chagas disease serological tests and outpatient visits recorded from 2004 to 2008 were screened for inclusion. The inclusion criterion was clinical suspicion of chronic Chagas disease and the exclusion criteria were previous diagnosis of Chagas disease, suspicion of acute Chagas disease, and serological tests with no corresponding medical evaluation. A total of 1,732 patients were analyzed. Chronic Chagas disease prevalence was 21.1%. After the initial set of serological tests, 2.9% of patients had inconclusive test results. Most of these patients had definite diagnosis after clinical follow-up and the repetition of serological tests in a new blood sample. Loss to follow-up while partaking in the diagnostic investigation reached 17.7%. The prevalence of initial inconclusive serological tests for chronic Chagas disease is low. Clinical evaluations and follow-up clarify the definite diagnosis. Noncompliance to follow-up is a frequent problem. Strategies to reduce inconclusive results and noncompliance are discussed.

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Anti-Trypanosoma cruzi antibody detection in blood donors in the Southern Brazil

Cited by 18 publications

References 19 publications

Prevalência da doença de Chagas entre doadores de sangue do Estado do Piauí, Brasil, no período de 2004 a 2013

Prevalência da doença de Chagas entre doadores de sangue do Estado do Piauí, Brasil, no período de 2004 a 2013

Prevalence of Trypanosoma Cruzi antibodies in blood donors from the Sao Paulo State, Brazil, between 2012 and 2014

Dealing with initial inconclusive serological results for chronic Chagas disease in clinical practice

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