Anti-Toxoplasma gondii RH strain activity of herbal extracts used in traditional medicine

Antiretroviral activity of protease inhibitors against Toxoplasma gondii

“…The compounds were toxic to mammalian host, with selectivity index from 6 to 15 and IC 50 values from 15.9 to 76.8 µg/mL. Sulfadiazine and pyrimethamine were active in a similar concentrations reported 3,5 . Nevertheless, both compounds showed higher cytotoxicity compared with APIs, with selectivity index of 4 and 1, respectively.…”

“…Three replicates were carried out and the results are presented as average ± standard deviation. Selectivity indices (SI) were then calculated by dividing the CC 50 for peritoneal macrophage of mice by the IC 50 for T. gondii 3 .…”

Human toxoplasmosis–Searching for novel chemotherapeutics

“…Both extracts have shown high selectivity toward T. gondii RH strain. Particularly in the case of Zingiber officinale, the value of EC 50 (half maximal effective concentration) determined for T. gondii was ten times lower than EC 50 for HeLa cells [75]. In other studies, two Eurycoma longifolia fractions [76], Dictamnus dasycarpus extract [77] as well as oleuropein isolated from Fraxinus rhynchopchylla [78] revealed significant anti-Toxoplasma activity.…”

In vitro activity of Piper sarmentosum ethanol leaf extract against <i>Toxoplasma gondii</i> tachyzoites

“…The results of the ethanol extracts of P. sarmentosum leaves were comparable to those of clindamycin (IC 50 = 7.2 ± 1.52 μg/mL) ( Figure 3 and Figure 4). A previous study by Saadatnia [21] concluded that the propagation of T. gondii parasites in Vero cells produced high yield and viability of tachyzoites, with minimal host cell contamination. Hence, Vero cells were used as the host cells for T. gondii in the present study to determine the anti-parasitic activity of the plant extracts.…”