Anti-Toxoplasma Activity of Natural Products: A Review

Sepúlveda-Arias, Juan Carlos; Veloza, Luz Ángela; Mantilla-Muriel, Luz Eliana

doi:10.2174/1574891x10666150410120321

Cited by 41 publications

(36 citation statements)

References 45 publications

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“…Anti (29,30). However, the development of safe and efficient agents for prophylactic and therapeutic purposes for toxoplasmosis is of principal importance, which needs a wide-ranging study of medicinal plants having the capability to destroy the parasite with minimum or no toxicity to humans.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Zataria multiflora Boiss Essential Oil against Acute Toxoplasmosis in Mice

Mahmoudvand

Kareshk

Moradi

et al. 2020

IJPA

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Background: Broad spectrums of pharmacological properties, including antimicrobial activity have been attributed to Zataria multiflora Boiss (Laminaceae). The in vivo efficacy and safety of Z. multiflora essential oil (ZM-EO) were evaluated against acute toxoplasmosis caused by Toxoplasma gondii (Sarcocystidae) in mice. Methods: Z. multiflora (aerial parts) was obtained from the rural districts of Kerman city (Kerman Province) Southwestern Iran, in May of 2016. Male NMRI mice were orally treated with normal saline (control group) and ZM-EO at the doses of 0.2 and 0.4 mL/kg once a day for 14 d (8 mice in each group). On the 15th day, the mice were infected with 104 tachyzoites of T. gondii RH strain by intraperitoneal route. The mortality rate and parasite load were determined in the infected mice. Additionally, 24 mice were applied to examine the sub-acute toxicity of ZM-EO at the above doses after treatment during 14 d. Results: GC/MS analysis displayed that the key constituents were thymol (45.4%), carvacrol (23%) and p-cymene (10.6%), respectively. Overall, 100% mortality was observed on the 8th and 9th days in treated mice with the concentrations of 0.2 and 0.4 mL/kg, respectively. The mean number of tachyzoites in the mice treated with 0.2 and 0.4 mL/kg of ZM-EO were 189×104 and 76×104 cell/mL, respectively, meaningfully (P<0.05) reduced compared with the control mice. Results also demonstrated that ZM-EO had no important toxicity on mice. Conclusion: The results demonstrated the efficacy of ZM-EO against acute toxoplasmosis. Nevertheless, supplementary surveys are mandatory to examine its precise effects, mainly immunomodulatory effect on toxoplasmosis.

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Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Zataria multiflora Boiss Essential Oil against Acute Toxoplasmosis in Mice

Mahmoudvand

Kareshk

Moradi

et al. 2020

IJPA

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“…Plant-derived natural products are now increasingly being found to have anti-Toxoplasma activity (Sepulveda-Arias et al, 2014). It is noteworthy that traditionally, in West Africa, S. bicolor grains, leaves, roots and stalks are considered to have medicinal properties and are thus used in the treatment of a range of ailments (Oladiji et al, 2007;Abugri et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

In vitro activity of Sorghum bicolor extracts, 3-deoxyanthocyanidins, against Toxoplasma gondii

Abugri

Witola

Jaynes

et al. 2016

Experimental Parasitology

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We investigated dried red leaf extracts of Sorghum bicolor for activity against Toxoplasma gondii tachyzoites. S. bicolor red leaf extracts were obtained by bioassay-guided fractionation using ethanol and ethyl acetate as solvents. Analysis of the crude and fractionated extracts from S. bicolor using electrospray ionization mass spectrometry (ESI-MS) showed that they contained significant amounts of apigeninidin, luteolinidin, 7-methoxyapigeninidin, 5-methoxyapigeninidin, 5-methoxyluteolinidin, 7-methoxyluteolinidin 5,7-dimethoxyapigeninidin or 5,7-dimethoxyluteolinidin, based on mass per charge (m/z). When tested in vitro, the IC50s for inhibitory activity against T. gondii tachyzoites' growth of the ethanol and ethyl acetate extracts were 2.3- and 4-fold, respectively, lower than their cytotoxic IC50s in mammalian cells. Ethyl acetate extracts fractionated in chloroform-methanol and chloroform had IC50s against T. gondii that were 56.1- and 3-fold lower than their respective cytotoxic IC50s in mammalian cells. These antiparasitic activities were found to be consistent with those of the respective pure 3-deoxyanthocyanidin compounds identified to be contained in the fractions in significant amounts. Further, we observed that, the position and number of methoxy groups possessed by the 3-deoyanthocyanidins influenced their antiparasitic activity. Together, our findings indicate that S. bicolor red-leaf 3-deoxyanthocyanidins-rich extracts have potent in vitro inhibitory activity against the proliferative stage of T. gondii parasites.

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“…Based on studies, approximately 70% of new anti-infective drugs are of natural origin, including 14 approved antiparasitics [19]. Natural products provide a unique structural variety, and a valuable opportunity for the discovery of new active compounds of low molecular weight [20]. …”

Section: Introductionmentioning

confidence: 99%

“…According to our previous study, the extracts of Feijoa sellowiana (leaves and fruits), Quercus castaneifolia (fruits), and Allium paradoxum (leaves) were evaluated against T. gondii [22]. Currently no natural products exist that have been patented for use in the treatment of toxoplasmosis [20]. …”

Section: Introductionmentioning

confidence: 99%

Anti-Toxoplasma Activities of Zea Mays and Eryngium Caucasicum Extracts, In Vitro and In Vivo

et al. 2019

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Anti-Toxoplasma Activity of Natural Products: A Review

Cited by 41 publications

References 45 publications

Efficacy and Safety of Zataria multiflora Boiss Essential Oil against Acute Toxoplasmosis in Mice

Efficacy and Safety of Zataria multiflora Boiss Essential Oil against Acute Toxoplasmosis in Mice

In vitro activity of Sorghum bicolor extracts, 3-deoxyanthocyanidins, against Toxoplasma gondii

Anti-Toxoplasma Activities of Zea Mays and Eryngium Caucasicum Extracts, In Vitro and In Vivo

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