Anti‐tissue transglutaminase antibodies in the follow‐up of adult coeliac disease

Dipper, C. R.; Maitra, Sohom; Thomas, Reena; Lamb, Christopher A; McLean‐Tooke, Andrew; Ward, Rachel; Smith, D; Spickett, GP; Mansfield, John C.

doi:10.1111/j.1365-2036.2009.04039.x

Cited by 60 publications

(51 citation statements)

References 39 publications

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“…18,21,23 An important insight provided by our study is the finding that antibodies can remain elevated despite adequate dietary compliance-a finding that challenges the conclusions drawn from other populations. 21,27,28 Despite complete mucosal healing (and thus presumed compliance), 13% had elevated coeliac antibodies. We were also unable to demonstrate better performance for a lower cut-off value for any antibody in predicting mucosal disease activity, as proposed.…”

Section: Discussionmentioning

confidence: 98%

Adherence to the gluten‐free diet can achieve the therapeutic goals in almost all patients with coeliac disease: A 5‐year longitudinal study from diagnosis

Newnham

Shepherd

Strauss

et al. 2016

J of Gastro and Hepatol

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Section: Discussionmentioning

confidence: 98%

Adherence to the gluten‐free diet can achieve the therapeutic goals in almost all patients with coeliac disease: A 5‐year longitudinal study from diagnosis

Newnham

Shepherd

Strauss

et al. 2016

J of Gastro and Hepatol

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“…In addition, adherence was defined meticulously by both dietary interview and serological testing, which is important in that patients may easily underestimate their inadvertent gluten intake when approached trough questionnaires only [8,21,35]. Limitation of the study was that a substantial number of participants were recruited via celiac societies.…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with Dietary Adherence in Celiac Disease: A Nationwide Study

Kurppa

Lauronen²,

Collin³

et al. 2012

Digestion

117

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Aims: Diagnostics and follow-up of celiac disease have gradually shifted from tertiary centers to secondary and primary health care. In order to establish whether this has affected the success of treatment, and to identify predictors for dietary non-adherence, we carried out a study in a nationwide cohort of treated celiac patients. Patients and Methods: 843 biopsy-proven patients, 94 children and 749 adults, were enrolled and interviewed. Adherence to a gluten-free diet was determined by means of an interview and serological testing. Results: Altogether, 88% were on a strict gluten-free diet; the rest had occasional dietary transgressions. Younger age at diagnosis, being currently a teenager, and current symptoms were associated with non-adherence. There was no association between non-adherence and place of diagnosis, gender, disease phenotype or severity of symptoms before diagnosis, presence of comorbidities, family history of celiac disease, smoking, duration of diet, use of oats, self-efficacy for the diet or lack of follow-up. Conclusions: Good dietary adherence can be achieved also in patients diagnosed and followed in primary health care. In a country with a high prevalence and good general knowledge of celiac disease, only age at diagnosis and age at present would appear to be major determinants for adherence.

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“…It is believed that tTG levels might be followed to reduce the risk of c omplic ations and monitor histologic al c hanges in the upper small bowel [66] .…”

Section: Mucosal Histologymentioning

confidence: 99%

Recent advances in celiac disease

Freeman

Chopra²,

Clandinin³

et al. 2011

WJG

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Celiac disease now affects about one person in a hundred in Europe and North America. In this review, we consider a number of important and exciting recent developments, such as clinical associations, HLA-DQ2 and HLA-DQ8 predispositions, the concept of potential celiac disease, the use of new imaging/endoscopy techniques, and the development of refractory disease. This review will be of use to all internists, pediatricians and gastroenterologists.

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Anti‐tissue transglutaminase antibodies in the follow‐up of adult coeliac disease

Abstract: SUMMARY BackgroundThe detection of auto antibodies directed against tissue transglutaminase (anti-tTG antibodies) has a well-established role in the diagnosis of coeliac disease, but the value of these antibodies in long-term followup is controversial.

Cited by 60 publications

References 39 publications

Adherence to the gluten‐free diet can achieve the therapeutic goals in almost all patients with coeliac disease: A 5‐year longitudinal study from diagnosis

Adherence to the gluten‐free diet can achieve the therapeutic goals in almost all patients with coeliac disease: A 5‐year longitudinal study from diagnosis

Factors Associated with Dietary Adherence in Celiac Disease: A Nationwide Study

Recent advances in celiac disease

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