Anti-thyroperoxidase antibodies from patients with Hashimoto's encephalopathy bind to cerebellar astrocytes

Blanchin, Stéphanie; Coffin, C.; Viader, Fausto; Ruf, Jean; Carayon, Pierre; Potier, F; Portier, Estelle; Comby, E.; Allouche, Stéphane; Ollivier, Yann; Reznik, Yves; Ballet, J.

doi:10.1016/j.jneuroim.2007.08.012

Cited by 100 publications

(64 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Regarding the association between thyroid autoimmunity and psychological well-being, Blanchin et al showed that anti-TPO antibodies bind to human cerebellar astrocytes of patients with Hashimoto's encephalopathy [19]. Therefore, the presence of high thyroid autoantibodies may lead to some alterations in the brain which might lead to poorer psychological well-being compared to the subjects without thyroid autoimmunity.…”

Section: Disclosurementioning

confidence: 99%

Is thyroid autoimmunity itself associated with psychological well-being in euthyroid Hashimoto’s thyroiditis?

et al. 2017

View full text Add to dashboard Cite

Section: Disclosurementioning

confidence: 99%

Is thyroid autoimmunity itself associated with psychological well-being in euthyroid Hashimoto’s thyroiditis?

et al. 2017

View full text Add to dashboard Cite

“…However, different from other autoimmune neurological disorders such as myasthenia gravis in which autoantibodies have definite mechanism [22], the role of antithyroid antibodies in the pathogenesis of HE is still not clear. Recently, Blanchin et al reported that anti-TPO antibody from HE patients were able to bind cerebellar astrocytes in HE patients but not in HT patients [23]. This may support the role of anti-TPO antibody in the pathogenesis of HE.…”

Section: Discussionmentioning

confidence: 89%

Hashimoto’s Encephalopathy with Reversible Diffuse Leukoencephalopathy

Hwang

Jeong

2018

J Neurocrit Care

View full text Add to dashboard Cite

Background: Hashimoto's encephalopathy is a poorly understood syndrome consisting of heterogeneous neurological symptoms and high serum antithyroid antibody titers, typically responding to steroids. More clinical series studies are required to characterize the clinical, laboratory and imaging features, and outcomes, especially in the Chinese population. Methods: We analyzed the clinical, laboratory, and imaging features and outcomes of thirteen consecutive patients with Hashimoto's encephalopathy diagnosed in Xuan Wu Hospital, Beijing from 2005 to 2010 retrospectively. Results: Cognitive impairment (84.6%) and psychiatric symptoms (38.5%) were the most frequent symptoms. Seizures (30.8%) and myoclonus (7.7%) were less common than previously described. Three (23.1%) patients showed abnormal signals in hippocampus or temporal lobe, which were believed related to their memory disorders or seizures. MRI changes showed resolution paralleling clinical improvement in one patient. Among eight patients who received steroid therapy, five patients recovered, one patient improved with residual deficits, and two patients relapsed or had no effect. Among five non-steroid treated patients, three patients experienced stable remission with antiepileptic drugs or general neurotrophic therapy, and two patients experienced continuous deterioration. Conclusions:Most patients with Hashimoto's encephalopathy showed good response to steroids. Some patients improved without steroid therapy. Considering its reversible course, we recommend that Hashimoto's encephalopathy should always be in the differential diagnosis while evaluating disorders of the central nervous system.

show abstract

“…The same study failed to prove any specific binding between anti-thyroglobulin IgG to a CNS structure. [5] A single study demonstrated that both Hashimoto's encephalopathy sera and anti-TPO monoclonal antibodies (mAb) were able to bind cerebellar cells expressing glial fibrillary acid protein using immunofluorescence assay of monkey cerebellum sections [6]. Normal human astrocytes from primary cultures also reacted with anti-TPO mAb [6].…”

Section: Discussionmentioning

confidence: 99%

Hashimoto’s encephalopathy in the setting of subclinical hypothyroidism

Bota¹,

Corrigan²

2011

IJCRI

View full text Add to dashboard Cite

Anti-thyroperoxidase antibodies from patients with Hashimoto's encephalopathy bind to cerebellar astrocytes

Cited by 100 publications

References 32 publications

Is thyroid autoimmunity itself associated with psychological well-being in euthyroid Hashimoto’s thyroiditis?

Is thyroid autoimmunity itself associated with psychological well-being in euthyroid Hashimoto’s thyroiditis?

Hashimoto’s Encephalopathy with Reversible Diffuse Leukoencephalopathy

Hashimoto’s encephalopathy in the setting of subclinical hypothyroidism

Contact Info

Product

Resources

About

Anti-thyroperoxidase antibodies from patients with Hashimoto's encephalopathy bind to cerebellar astrocytes

Cited by 100 publications

References 32 publications

Is thyroid autoimmunity itself associated with psychological well-being in euthyroid Hashimoto&rsquo;s thyroiditis?

Is thyroid autoimmunity itself associated with psychological well-being in euthyroid Hashimoto&rsquo;s thyroiditis?

Hashimoto’s Encephalopathy with Reversible Diffuse Leukoencephalopathy

Hashimoto’s encephalopathy in the setting of subclinical hypothyroidism

Contact Info

Product

Resources

About

Is thyroid autoimmunity itself associated with psychological well-being in euthyroid Hashimoto’s thyroiditis?

Is thyroid autoimmunity itself associated with psychological well-being in euthyroid Hashimoto’s thyroiditis?