Anti-thrombin action of low-dose acetylsalicylic acid

Micco, B. Di; Colonna, Giovanni; Micco, Pierpaolo Di; Micco, Gianluca Di; Russo, Bianca; Macalello, M.A.; Ragone, Raffaele

doi:10.1016/s0014-2999(02)02925-4

Cited by 11 publications

(4 citation statements)

References 18 publications

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“…Our findings validate previously published reports (10,16) suggesting that older age and African-American race are independent risk factors for RCC. Our findings thus corroborate our own clinical observations and seropositivity data, as well as frequent anecdotal reports in the literature that have strongly suggested an association between chronic HCV infection and RCC (11)(12)(13)(14)17).…”

Section: Discussionsupporting

confidence: 92%

“…It has been noted that IFN-α, which is indicated for treatment of chronic HCV infection, is also used to help stabilize advanced RCC (11,25). In addition, there is evidence that HCV patients who achieve viral eradication following IFN therapy have a lower incidence of malignant lymphoma (26).…”

Section: Discussionmentioning

confidence: 99%

“…Di Micco et al (11) reported a cluster of five cases of RCC developing among HCV patients within a brief time frame and were the first to strongly suggest a renal oncogenic potential for HCV infection. Fayek et al (12) in 2007 reported two cases of coexisting HCV and RCC in liver transplant candidates, and Garcia et al (13) in 2007 reported synchronous hepatocellular carcinoma and RCC in a liver transplant recipient.…”

Section: Introductionmentioning

confidence: 99%

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Risk for Renal Cell Carcinoma in Chronic Hepatitis C Infection

Gordon

Moonka

Brown

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Chronic infection with hepatitis C virus (HCV) confers increased risk for chronic renal disease, and numerous reports suggest an association with renal cell carcinoma (RCC), a cancer with rapidly rising global incidence. We sought to determine whether HCV infection confers an increased risk for developing RCC.Methods: With the use of administrative data from a large, integrated, and ethnically diverse healthcare system, we did a cohort study of 67,063 HCV-tested patients between 1997 and 2006 who were followed for the development of RCC until April 2008.Results: A search of the health system cancer registry for patients with the diagnosis of kidney cancer showed that RCC was diagnosed in 0.6% (17 of 3,057) of HCV-positive patients versus 0.3% (177 of 64,006) of HCV-negative patients. The mean age at RCC diagnosis was much younger in HCV-positive individuals (54 versus 63; P < 0.001). The univariate hazard ratio for RCC among HCV patients was 2.20 (95% confidence interval, 1.32-3.67; P = 0.0025). In a multivariate model that included the risk factors age, African-American race, male gender, and chronic kidney disease, the overall hazard ratio for RCC among HCV patients was 1.77 (95% confidence interval, 1.05-2.98; P = 0.0313).Conclusion: Chronic HCV infection confers a risk for the development of RCC. Impact: Clinicians should consider newly identified renal lesions in patients with chronic HCV infection with a heightened suspicion for neoplasm, and newly diagnosed cases of RCC may require more careful surveillance for the presence of HCV infection. Additional studies are required to confirm these findings and to explore potential mechanisms of oncogenesis. Cancer Epidemiol Biomarkers Prev; 19(4); 1066-73. ©2010 AACR.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Risk for Renal Cell Carcinoma in Chronic Hepatitis C Infection

Gordon

Moonka

Brown

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…In vitro activation of clotting with measurement of TAT and fibrinopeptide A showed no suppression by aspirin when patients ingested the drug before the blood draw [16]. Aspirin did not suppress thrombin generation among patients with coronary artery disease, nor among those receiving aspirin alone in the Stroke Prevention Atrial Fibrillation III study [17,18]. Aspirin had some effect suppressing F1 + 2 in the antiphospholipid syndrome, but without consistency among the patients studied [19].…”

Section: Discussionmentioning

confidence: 99%

Effects of anticoagulation on markers of activation of clotting following major orthopedic surgery

Bern

Hazel

Reilly

et al. 2015

Int J Lab Hematology

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IntroductionThis study examines makers of activation of clotting following three chemoprophylactic regimens used for prevention of postoperative venous thromboembolic disease (TED) following high-risk surgery for TED.MethodsPatients having elective primary knee or hip replacement surgery received variable dose warfarin (target international normalized ratios 2.0–2.5), 1 mg warfarin daily starting 7 days preoperatively or aspirin 325 mg daily starting on the day of surgery. Twelve patients in each group were treated for 28 ± 2 days. Thrombin–antithrombin (T-AT) and prothrombin fragment F1 + 2 were measured at baseline and postoperative days 3 and 28 ± 2.ResultsThrombin–antithrombin and F1 + 2 on postoperative day 3 were equal for the study groups. By days 28 ± 2, variable dose warfarin therapy group suppressed production of F1 + 2 (P = 0.002) with no difference in the T-AT accumulation. F1 + 2 for other patients overlapped the normal range.ConclusionThe signals of activated clotting following surgery did not differentiate the three regimens on postoperative day 3. Variable dose warfarin was associated with suppression of F1 + 2 after 1 month of therapy, with no effect on accumulation of T-AT. Fixed low-dose warfarin started 7 days prior to surgery and aspirin are not inferior on postoperative day 3, but appear to be inferior over a longer treatment.

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Vitamin K

Paul¹

2020

Textbook of Natural Medicine

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Anti-thrombin action of low-dose acetylsalicylic acid

Cited by 11 publications

References 18 publications

Risk for Renal Cell Carcinoma in Chronic Hepatitis C Infection

Risk for Renal Cell Carcinoma in Chronic Hepatitis C Infection

Effects of anticoagulation on markers of activation of clotting following major orthopedic surgery

Vitamin K

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