Anti-teratogenic potential and curtailing toxicity of valproic acid

Abstract

Oxidative stress responsible for causing damage in the building material of cellular macromolecules such as DNA, lipids, and proteins, along with changing redox-sensitive signaling pathways MOJ Toxicol. 2018;4(4):289-293. 289 AbstractValproic acid (VPA) is widely used as an anticonvulsant and mood-stabilizing drug. It is highly prescribed drug, particularly for epilepsy. However, besides beneficial VPA have a number of side effects due to affecting several signaling pathways through different mechanisms. VPA act as a potent teraogen causing birth defects via interfering with folate metabolism or oxidative stress generation, and histone deacetylase inhibition. However, this article aims to give an overview of the these adverse consequences of VPA are significantly curtailed by the various substances like Vitamin E, Ascorbic Acid, Folic acid, Pantothenic acid, S-adenosyl methionine (SAM) and Curcumin etc which can be focus on its therapeutic use in future against it because of no such other alternative.