Anti-sulfatide antibodies in neuropathy

Quattrini, Angelo; Corbo, M; Dodd, J.; Dhaliwal, S.K.; Sadiq, Saud; Uncini, Antonino; Hays, Arthur P.; Latov, N.

doi:10.1016/0165-5728(91)90932-w

Cited by 2 publications

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“…A close correlation between the number of widely spaced myelin lamellae and the deposition of IgM has been demonstrated [16]. Sulfatide is a common glycolipid in peripheral nerve myelin and dorsal root ganglia [12,14]. Various patterns of anti-sulfatide IgM antibody binding to neural tissue have been reported.…”

Section: Discussionmentioning

confidence: 93%

Polyneuropathy attributes: a comparison between patients with anti-MAG and anti-sulfatide antibodies

Erb

Ferracin

Fuhr

et al. 2000

Journal of Neurology

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Thirty-two patients with a peripheral neuropathy and paraproteinemia were tested for IgM antibodies against myelin-associated protein (MAG) and sulfatide by means of enzyme-linked immunosorbent assay. Nine patients (28 %) had increased anti-sulfatide IgM antibodies and showed a chronic, slowly progressive, distally pronounced, and symmetric polyneuropathy with sensory to sensory-motor impairment, ataxia, hyporeflexia, and axonal involvement in electrophysiological studies. Ten patients (31 %) with increased anti-MAG antibodies had a similar, homogeneous polyneuropathy syndrome but presented with demyelinating features. A weak cross-reactivity between anti-MAG and anti-sulfatide antibodies was present in only three patients. In conclusion, although the two neuropathy groups clearly differed in their electrophysiological features, their clinical presentation was rather similar.

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Section: Discussionmentioning

confidence: 93%

Polyneuropathy attributes: a comparison between patients with anti-MAG and anti-sulfatide antibodies

Erb

Ferracin

Fuhr

et al. 2000

Journal of Neurology

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Anti-sulphatide antibodies in peripheral neuropathy.

Berg¹,

Lankamp²,

Jager³

et al. 1993

Journal of Neurology, Neurosurgery & Psychiatry

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A study was carried out on 135 patients with chronic idiopathic neuropathy (63), neuropathy associated with monoclonal gammopathy (51, including eight with anti-MAG antibody activity) and the Guillain-Barre syndrome (GBS) (21). Serum IgM, IgG and IgA anti-sulphatide antibody titres were compared with titres in 304 patients with other neurological or immunological diseases and in 50 normal subjects. Titres were presented a) as the highest serum dilution at which reactivity could be detected, and b) in the linear region of the optical density curve. A substantial number of patients with neurological or immunological diseases had higher titres than normal subjects.

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Anti-sulfatide antibodies in neuropathy

Cited by 2 publications

References 0 publications

Polyneuropathy attributes: a comparison between patients with anti-MAG and anti-sulfatide antibodies

Polyneuropathy attributes: a comparison between patients with anti-MAG and anti-sulfatide antibodies

Anti-sulphatide antibodies in peripheral neuropathy.

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