Abstract:Humanin (HN) is a secretory 24-residue peptide. HN was first identified as a cytoprotective factor that suppresses neuronal death in Alzheimer's disease and exerts the activity through cell surface receptors. Subsequent studies revealed that HN can reverse disease-associated change in cellular functions of various types of tissues including brain, muscle, and pancreas. It is also reported that HN increases mitochondrial ATP production in some cell types. The level of HN in circulation decreases age-dependently… Show more
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