Anti-Stress Activity of Some Plants Extracts of the North Caucasus Flora

Abstract

To date, stress is a common medical and socially significant disease that requires rational pharmacotherapeutic correction.The anti-stress properties of ethnolic and aqueous extracts obtained from leaves of Ribes nigrum L., inflorescences of Gaillardia pulchella Foug., stems of Lysimachia punctata L were studied in this work. Acute stress was modeled by immobilization of rats for 2h. The test-extracts were administered per os prophylactically in a dose of 1/20 of LD50 (2000mg/kg). The following parameters were evaluated: organs mass coefficient (adrenal glands, thymus, spleen), the number of stomach erosion; the biochemical changes in the blood serum (adrenaline, cortisol, total protein and glucose concentration); the mitochondrial function parameters in brain and myocardium (evaluation of mitochondrial pore transitional permeability opening and mitochondrial membrane potential). 70% ethanol extract from Gaillardia pulchella Foug. inflorescences has the highest anti-stress activity, the course application of which contributed to the normalization of the weight index of organs, a decrease in glucose concentration by 64.5% (p <0.05), and cortisol by 73.7% (p <0.05) and adrenaline -78.9% (p <0.05) in the blood, an increase in total protein level by 62.5% (p <0.05) and stabilization of mitochondrial function. The study showed a high anti-stress activity of 70 % ethanol extract from Gaillardia pulchella Foug. inflorescences.

Evaluation of Phytochemical and Antistress Activity of Averrhoa carambola L.

“…Stress disorders are on the rise in modern society, and the average person is constantly exposed to potentially stressful situations. 1 Currently, stress is a frequent medical condition with major societal consequences that calls for logical pharmacotherapeutic treatment. Increased blood levels of corticosteroids and adrenaline are two of the most important pathogenic mechanisms of stress.…”