Anti stress activity of olea europaea

Abstract

Stress and stressor-related disorders are the global illnesses. The immune system is thought to be strengthened by apoptogenic substances due to their ability of restoring normal body functions, which were imbalanced due to the presence of stressful conditions. The aim of study is to evaluate anti stress potential in ethanolic extract of () leaves on swimming endurance test in mice, cold and immobilization stress in rats. The effect was assessed by swimming survival time and estimation of biochemical parameter, weight of gland, organs, blood count in cold and immobilization stress at a dose 400 and 600 mg/kg per oral(p.o).The results demonstrated on comparison with stress models with leaf extract and Gerifort Syrup showing significant increase (p<0.001) in swimming time, significant decrease (p<0.001) in blood glucose, cholesterol, triglyceride (TG), plasma cortisol and Blood urea nitrogen (BUN) levels and also decrease in the weight of adrenal gland and organs weights. Blood cell count such as WBC, polymorphs and neutrophils significant decrease (p<0.01) under physiological limits. It was experimentally compared to control and gerifort group. Thus, obtained results revealed that the leaf extract of have potential Anti-stress activity due to the existence of phenolic compounds, especially secoiridoids and iridoids and antioxidant molecules, such as oleuropein, hydroxytyrosol, tyrosol, caffeic acid, and ligstroside proving its significant anti stress activity.