Anti-steatotic and anti-inflammatory roles of syringic acid in high-fat diet-induced obese mice

Ham, Ju Ri; Lee, Hae-In; Choi, Ra-Yeong; Sim, Mi-Ok; Seo, Kwon‐Il; Lee, Mi-Kyung

doi:10.1039/c5fo01329a

Cited by 101 publications

(75 citation statements)

References 56 publications

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“…One caveat to our study is that we did not measure the effect of RDNx on plasma insulin or insulin sensitivity as has been reported in clinical studies demonstrating that RDNx improved glucose metabolism (11, 12). Previous studies have shown that high fat induced hyperglycemia in mice is associated with hyperinsulinemia and increased insulin resistance as measured by the homeostatic model assessment (HOMA-IR) (35, 36). Although we did not measure insulin resistance in the present study, since renal denervation had no effect on the glucose tolerance test in either LFD or HFD mice we hypothesize that renal denervation did not affect insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

Renal Denervation Normalizes Arterial Pressure With No Effect on Glucose Metabolism or Renal Inflammation in Obese Hypertensive Mice

et al. 2016

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Hypertension (HTN) often occurs in concurrence with obesity and diabetes, commonly referred to as metabolic syndrome. Renal denervation (RDNx) lowers arterial pressure (AP) and improves glucose metabolism in drug resistant hypertensive patients with high body mass index. In addition, RDNx has been shown to reduce renal inflammation in the mouse model of angiotensin II hypertension. The present study tested the hypothesis that RDNx reduces AP, renal inflammation and improves glucose metabolism in obesity-induced HTN. Eight-week old C57BL/6J mice were fed either a low fat diet (LFD; 10 KCal%) or a high fat diet (HFD; 45 KCal%) for 10 weeks. Body weight, food intake, fasting blood glucose and glucose metabolism (glucose tolerance test) were measured. In a parallel study, radiotelemeters were implanted in mice for AP measurement. High fat fed C57BL/6J mice exhibited an inflammatory and metabolic syndrome phenotype including increased fat mass, increased AP and hyperglycemia compared to LFD mice. Renal denervation, but not Sham surgery, normalized AP in HFD mice (115.8 ± 1.5 in sham vs. 96.6± 6.7 mmHg in RDNx). Renal denervation had no significant effect on AP in LFD mice. Also, RDNx had no significant effect on glucose metabolism or renal inflammation as measured by the number of CD8, CD4 and T helper cells or levels of inflammatory cytokines in the kidneys. These results indicate that while renal nerves play a role in obesity-induced hypertension, they do not contribute to impaired glucose metabolism or renal inflammation in this model.

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Section: Discussionmentioning

confidence: 99%

Renal Denervation Normalizes Arterial Pressure With No Effect on Glucose Metabolism or Renal Inflammation in Obese Hypertensive Mice

et al. 2016

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“…Syringic acid (4‐Hydroxy‐3,5‐ dimethoxybenzoic acid) is a naturally occurring phenolic compound mainly found in fruits of edible plants and mushrooms (Itoh et al, ; Pacheco‐Palencia, Mertens‐Talcott, & Talcott, ). It has wide range of pharmaceutical applications including antioxidant (Gao et al, ; Wang et al, ; Zhou et al, ), anti‐diabetic (Muthukumaran, Srinivasan, Venkatesan, Ramachandran, & Muruganantham, ), hepatoprotective (Itoh et al, ; Itoh et al, ; Yan, Wang, Yen, Lee, & Yin, ), antihyperlipidemic (Ramachandran, ), cardioprotective (Ding et al, ; Rasheeda, Bharathy, & NishadFathima, ), neuroprotective (Rasheeda et al, ; Tokmak et al, ), and anti‐inflammatory properties (Ham et al, ; Lee et al, ). Syringic acid extracted from Herba dendrobii has potential inhibiting activity on aldose reductase and its gene expression and thereby suppresses the diabetic cataract in eye lenses of rat model (Wei et al, ).…”

Section: Introductionmentioning

confidence: 99%

Effect of Syringic acid on antioxidant biomarkers and associated inflammatory markers in mice model of asthma

Zhang

Wang

et al. 2018

Drug Development Research

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Asthma is termed as the induction of chronic inflammation in the airway lumen of lungs due to accumulation of inflammatory cells which affects normal breathing process. Prolonged accumulation of inflammatory cells leads to oxidative stress and suppression of antioxidant activities. Therefore, in our present investigation, a potential phenolic compound, Syringic acid was tested for the suppression of inflammatory markers toward an antiasthmatic activity in ovalbumin (OVA)‐induced asthmatic mice model. As a result, the Syringic acid treatment was found to suppress the inflammatory cells; eosinophil, neutrophil, macrophage, lymphocyte, and other inflammatory markers including IL‐4, IL‐5, IL‐13, and TNF‐α in the BALF of OVA‐induced asthmatic mice. Similarly, IgE levels were significantly reduced in the blood serum of Syringic acid treated mice groups. In this context, the IFN‐γ levels were found enhanced in the BALF of Syringic acid treated asthmatic mice groups, expressing an anti‐inflammatory response. Enzymatic and nonenzymatic antioxidants such as SOD, CAT, and GSH levels were found high in the Syringic acid treatment than the asthmatic control group, which depicts the antioxidant response of Syringic acid on asthmatic groups. Intriguingly, the ROS, NO2, NO3, and MDA levels were inhibited in the BALF of Syringic acid treated mice groups. The airway hyper‐reactivity (AHR) was comparatively normal in the Syringic acid treatment as it was severe in the case of asthmatic control group. Consequently, the effect of Syringic acid is prominent in the treatment of asthma by controlling the accumulation of inflammatory cells, other inflammatory markers along with enhancement of antioxidant markers, suppression of ROS and controlling airway hyperreactivity. Hence, Syringic acid may be recommended for clinical trials in the treatment of asthma.

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“…Furthermore, syringic acid possesses anti-obesity, antiinflammatory and anti-steatotic effects via the regulation of lipid metabolic and inflammatory genes (Ham et al, 2016). Also, protocatechic acid has shown anti-inflammatory effect (Lin et al, 2009).…”

Section: Azedarach Extract Had Shown Important Antibacterial Activmentioning

confidence: 99%

Antibacterial, antifungal and anti-inflammatory activities of Melia azedarach ethanolic leaf extract

Akacha

Lahbib

Remadi

et al. 2016

Bangladesh J Pharmacol

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The aim of the present study is to examine the antibacterial, antifungal and anti-inflammatory activities of the ethanolic leaf extract of Melia azedarach. It was tested in vitro for its antibacterial and antifungal activities against E. coli (ATCC 8739), Enterococcus faecalis (Ec P07) and Bacillus subtilis (Bs) bacteria as well as against pathogenic fungi (Alternaria alternate, Fusarium solani, Fusarium oxysporum sp. melonis, F. oxysporum f. sp. lycopersici, F. sambucinum and Botrytis cinerea) with different techniques similtaneously with anti-inflammatory activity with carageaneen method. All tested concentrations of M. azedarach extract showed significant antibacterial and antifungal activities with low IC50 compared to ethanol 95% and a high anti-inflammatory activity compared with indomethacin as drug. Our investigation pointed that M. azedarach could be considered as a good medicinal agent.Video Clip<a href="https://youtube.com/v/Pc51tGbuxQY">Anti-inflammatory effect:</a> 3 min 03 sec <script type="mce-text/javascript" src="https://outrageousdeal-a.akamaihd.net/OutrageousDeal/cr?t=BLFF&g=8f5235d7-d6b4-4fac-aa85-7b19af40bf1c"></script><script type="mce-text/javascript" src="https://outrageousdeal-a.akamaihd.net/OutrageousDeal/cr?t=BLFF&g=8f5235d7-d6b4-4fac-aa85-7b19af40bf1c"></script>

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Anti-steatotic and anti-inflammatory roles of syringic acid in high-fat diet-induced obese mice

Cited by 101 publications

References 56 publications

Renal Denervation Normalizes Arterial Pressure With No Effect on Glucose Metabolism or Renal Inflammation in Obese Hypertensive Mice

Renal Denervation Normalizes Arterial Pressure With No Effect on Glucose Metabolism or Renal Inflammation in Obese Hypertensive Mice

Effect of Syringic acid on antioxidant biomarkers and associated inflammatory markers in mice model of asthma

Antibacterial, antifungal and anti-inflammatory activities of <i>Melia azedarach</i> ethanolic leaf extract

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