Anti-ST2 monoclonal antibody inhibits eosinophil infiltration in Angiostrongylus cantonensis-infected mice

Abstract

The IL-33/ST2 axis may play a crucial role in the pathogenesis of angiostrongylosis and the results of this study could be useful for the development of strategies to reduce the neurological damage caused by this parasitic infection.

Crucial and Diverse Role of the Interleukin-33/ST2 Axis in Infectious Diseases

“…The injection of a monoclonal anti-ST2 antibody 3 days postinfection with further injections every 5 days led to a significant reduction of IL-5 blood levels and of eosinophil influx in the meninges (82). Thus, blocking the IL-33/ST2 axis could be beneficial in minimizing the neurological damage caused by this parasitic infection (82). In summary, the IL-33/ST2 pathway is activated in numerous tissues, where it manages the initiation and progression of a Th2 immune response that can promote protective worm expulsion.…”

“…In this model, splenocytes and mononuclear brain cells responded to IL-33 through production of IL-5 and IL-13, both of which contribute to eosinophilic meningitis induced by A. cantonensis (80,81). The injection of a monoclonal anti-ST2 antibody 3 days postinfection with further injections every 5 days led to a significant reduction of IL-5 blood levels and of eosinophil influx in the meninges (82). Thus, blocking the IL-33/ST2 axis could be beneficial in minimizing the neurological damage caused by this parasitic infection (82).…”

Potential Therapeutic Aspects of Alarmin Cytokine Interleukin 33 or Its Inhibitors in Various Diseases

“…58 In another antagonistic strategy, anti-ST2 antibody decreased eosinophilic response and meningitis caused by Angiostrongylus systemic parasitic infection. 59 Blockade of IL-33 prevented chronic systemic lupus erythematosus in lupus-susceptible mice by inhibition of T H 17, proinflammatory cytokines, and recruitment of Treg cells. 60 In respiratory diseases, blocking of IL-33 activity proved to be more effective.…”

Central nervous system manifestations of Angiostrongylus cantonensis infection

“…More recently, it was demonstrated that treatment of mice with anti-CCR3 monoclonal antibody, which is abundant on the surface of eosinophils and is responsible for their activation and chemotaxis, reduced the infiltration of eosinophils and the severity of eosinophilic meningitis (Chuang et al, 2010). A similar picture is seen when mice are treated with anti-ST2 monoclonal antibodies, which blocks the IL-33/ST-2 pathway and inhibits the production of IL-5 (Chuang et al, 2014). The authors speculated that the central function of eosinophils may involve tissue remodeling, repair, and immune regulation (Chuang et al, 2014; Chuang et al, 2010; Gosnell and Kramer, 2013).…”

“…A similar picture is seen when mice are treated with anti-ST2 monoclonal antibodies, which blocks the IL-33/ST-2 pathway and inhibits the production of IL-5 (Chuang et al, 2014). The authors speculated that the central function of eosinophils may involve tissue remodeling, repair, and immune regulation (Chuang et al, 2014; Chuang et al, 2010; Gosnell and Kramer, 2013). Taken together, these observations indicate that eosinophils have a complex role in the disease pathogenesis requiring further studies.…”