Anti-Sporothrix Antibody Detection in Domestic Cats as an Indicator of a Possible New Occurrence Area for Sporotrichosis in North Brazil

Bernardes-Engemann, Andréa Reis; Almeida, Marcos de Abreu; Bison, Ividy; Rabello, Vanessa Brito de Souza; Ramos, Mariana Lucy Mesquita; Pereira, Sandro Antônio; Almeida‐Paes, Rodrigo; Brasil, Arthur Willian de Lima; Zancopé‐Oliveira, Rosely Maria

doi:10.1007/s11046-022-00644-7

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…The current scenario of sporotrichosis shows signs of frank expansion. The map was drawn based on case reports available on the literature [ 5 , 10 , 12 , 15 , 31 , 32 , 68 , 91 , 98 , 99 , 100 , 101 , 105 , 108 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 ].…”

Section: Figurementioning

confidence: 99%

Current Progress on Epidemiology, Diagnosis, and Treatment of Sporotrichosis and Their Future Trends

Rodrigues

Gonçalves

Carvalho

et al. 2022

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Sporotrichosis, a human and animal disease caused by Sporothrix species, is the most important implantation mycosis worldwide. Sporothrix taxonomy has improved in recent years, allowing important advances in diagnosis, epidemiology, and treatment. Molecular epidemiology reveals that S. brasiliensis remains highly prevalent during the cat-transmitted sporotrichosis outbreaks in South America and that the spread of S. brasiliensis occurs through founder effects. Sporothrix globosa and S. schenckii are cosmopolitan on the move, causing major sapronoses in Asia and the Americas, respectively. In this emerging scenario, one-health approaches are required to develop a creative, effective, and sustainable response to tackle the spread of sporotrichosis. In the 21st century, it has become vital to speciate Sporothrix, and PCR is the main pillar of molecular diagnosis, aiming at the detection of the pathogen DNA from clinical samples through multiplex assays, whose sensitivity reaches remarkably three copies of the target. The treatment of sporotrichosis can be challenging, especially after the emergence of resistance to azoles and polyenes. Alternative drugs arising from discoveries or repositioning have entered the radar of basic research over the last decade and point to several molecules with antifungal potential, especially the hydrazone derivatives with great in vitro and in vivo activities. There are many promising developments for the near future, and in this review, we discuss how these trends can be applied to the Sporothrix-sporotrichosis system to mitigate the advance of an emerging and re-emerging disease.

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Section: Figurementioning

confidence: 99%

Current Progress on Epidemiology, Diagnosis, and Treatment of Sporotrichosis and Their Future Trends

Rodrigues

Gonçalves

Carvalho

et al. 2022

JoF

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“…This ELISA protocol was also validated for diagnosis of sporotrichosis in cats, with better efficiency than the S. schenckii concanavalin-A binding antigenic fraction, as seen with human sera [ 166 ]. In addition, it was used to investigate an area supposedly without sporotrichosis endemicity, but with around 31% of positive samples from cats living in urban areas of the city [ 167 ]. Alvarado and collaborators developed an ELISA using a similar antigen produced by S. schenckii .…”

Section: Sporotrichosismentioning

confidence: 99%

Immunologic Diagnosis of Endemic Mycoses

Almeida‐Paes

Bernardes-Engemann

Motta

et al. 2022

JoF

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The endemic mycoses blastomycosis, coccidioidomycosis, histoplasmosis, paracoccidioidomycosis, cryptococcosis, sporotrichosis, talaromycosis, adiaspiromycosis, and emergomycosis are mostly caused by geographically limited thermally dimorphic fungi (except for cryptococcosis), and their diagnoses can be challenging. Usual laboratory methods involved in endemic mycoses diagnosis include microscopic examination and culture of biological samples; however, serologic, histopathologic, and molecular techniques have been implemented in the last few years for the diagnosis of these mycoses since the recovery and identification of their etiologic agents is time-consuming and lacks in sensitivity. In this review, we focus on the immunologic diagnostic methods related to antibody and antigen detection since their evidence is presumptive diagnosis, and in some mycoses, such as cryptococcosis, it is definitive diagnosis.

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Anti-Sporothrix Antibody Detection in Domestic Cats as an Indicator of a Possible New Occurrence Area for Sporotrichosis in North Brazil

Cited by 2 publications

References 28 publications

Current Progress on Epidemiology, Diagnosis, and Treatment of Sporotrichosis and Their Future Trends

Current Progress on Epidemiology, Diagnosis, and Treatment of Sporotrichosis and Their Future Trends

Immunologic Diagnosis of Endemic Mycoses

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