Anti-solvent crystallization behavior of triphenylmethanol in a droplet-based microfluidic device

Yan, Jinrui; Lü, Jun; Qiu, Junjie; Guo, Yaohao; Zhao, Teng; Bao, Bo

doi:10.1016/j.ces.2023.118971

Cited by 3 publications

(2 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Next, we observed the oiling-out crystallization process by a microfluidic platform mentioned in our previous work . A total of 0.2 g of pyraclostrobin was weighed and then dissolved in 20 mL of isopropanol.…”

Section: Methodsmentioning

confidence: 99%

Microfluidic Crystallization for Screening of Spherical Particles of Pyraclostrobin

Zhong,

Guo,

Bao

2024

Ind. Eng. Chem. Res.

Self Cite

View full text Add to dashboard Cite

The semicontinuous antisolvent crystallization process of pyraclostrobin was investigated utilizing an integrated microfluidic device that encompasses both microfluidic channels and an agitated crystallizer. We successfully regulated the crystal morphology as quasi-spherical particles and narrowed the particle size distribution compared with that of the raw materials. We explored the impact of ultrasound powers, initial concentration, antisolvent content, and stirring rate on crystal morphology. Our innovative approach involves precisely manipulating the stirring rate and solvent content, resulting in diverse crystal morphologies. Notably, we unveil two distinct mechanisms governing the formation of spherical particles, which can be attributed to the variability in the oil droplet sizes. Our apparatus and approach enable the efficient screening of spherical particles, advocating minimal reagent consumption. This achievement holds the potential to be scaled across a variety of fields ranging from pharmaceuticals to material science.

show abstract

Section: Methodsmentioning

confidence: 99%

Microfluidic Crystallization for Screening of Spherical Particles of Pyraclostrobin

Zhong,

Guo,

Bao

2024

Ind. Eng. Chem. Res.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Ultrasound-assisted and microfluidics-assisted antisolvent crystallization methods were also reviewed for their promoting effects on micromixing of solvent and antisolvent, which is one of the pertinent factors in antisolvent crystallization [95][96][97][98][99][100]. One of the major problems for large-scale production of pharmaceuticals using ultrasound-assisted antisolvent crystallization is the need for special equipment to maintain homogenous ultrasound energy throughout the reactor.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Recent Progress in Antisolvent Crystallization of Pharmaceuticals with a Focus on the Membrane‐Based Technologies

Haghighizadeh,

Mahdavi,

Rajabi

2024

Chem Eng & Technol

View full text Add to dashboard Cite

Continuous crystallization of pharmaceuticals has been in the center of attention during the past two decades, with a more focus on the large‐scale production of active pharmaceutical ingredients. The increasing demand for pharmaceuticals requires high‐throughput production of drug crystals with different solubilities, stabilities, shapes, habits, polymorphs, and size distributions. With numerous advantages including low cost, ease of scale‐up, and superior control over polymorph and size distribution of drug crystals, antisolvent crystallization is one of the most promising crystallization methods recently attempted. However, it fails to deliver the required characteristic where the crystal systems tend to grow and for the preparation of metastable polymorphs. This review focuses on the most recent efforts to tackle these drawbacks by coupling antisolvent crystallization with cooling, supercritical‐assisted, microfluidics‐assisted, and membrane‐assisted crystallization. This systematic review aims to provide a concise summary of each coupled antisolvent technique and their positive and negative aspects. This review can be used as a guideline for pharmacist, biologists, and chemists, who are interested in the crystal engineering of pharmaceuticals to pave the way for further developments in this field.

show abstract

Over a decade of progress: Crystallization in microfluidic systems

Jang,

Kim,

Seo

et al. 2024

Chemical Engineering Journal

View full text Add to dashboard Cite

Anti-solvent crystallization behavior of triphenylmethanol in a droplet-based microfluidic device

Cited by 3 publications

References 74 publications

Microfluidic Crystallization for Screening of Spherical Particles of Pyraclostrobin

Microfluidic Crystallization for Screening of Spherical Particles of Pyraclostrobin

Recent Progress in Antisolvent Crystallization of Pharmaceuticals with a Focus on the Membrane‐Based Technologies

Over a decade of progress: Crystallization in microfluidic systems

Contact Info

Product

Resources

About