Anti-solvent and co-solvent effect of CO2 on the solubility of griseofulvin in acetone and ethanol solutions

Morphology and growth control of griseofulvin recrystallized by compressed carbon dioxide as antisolvent

“…Solvent and conditions were selected from thermodynamic data that reported solubility of griseofulvin in CO 2 +acetone mixtures [20].…”

The impinging jets technology: A contacting device using a SAS process type

“…However, very few information was obtained on this system. In the case of acetone, De Gioannis et al [5] gave some solubility values of griseofulvin at 39°C and 10 MPa: 0.65· 10 − 3 mol mol − 1 for X =34% and 6.15· 10 − 7 mol mol − 1 for X = 0%. Between these two values, particularly in our case X =10%, it is difficult to extrapolate, but this solubility is non negligible and can explain the reported yield.…”

Particle Formation and Product Formulation Using Supercritical Fluids

“…The initial concentration of the solution and the solvent/antisolvent ratio are the most influential parameters when operating above the mixture critical point, whereas the fluid mechanics parameters, including nozzle and precipitator design, only slightly influence the process (113). Additionally, when operating above or below mixture critical point, the precipitation mechanism and particle characteristics reportedly are different (114)(115)(116)(117)(118)(119)(120)(121). Martin & Cocero (122) and Sierra-Pallares et al (123) developed a model to analyze the mechanism of particle formation in the SAS process and to study the effects of the operating parameters on particle size and solid recovery.…”