Anti-snake venom: use and adverse reaction in a snake bite study clinic in Bangladesh

Amin, Ruhul; Mamun, Smh; Rashid, Rehnuma; Rahman, Mohammad Masudur; Ghose, Aniruddha; Sharmin, Sadia; Rahman, Md. Sadique; Faiz, MA

doi:10.1590/s1678-91992008000400009

Cited by 41 publications

(23 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For the same reason, males were more afflicted with bites than females. Similar results have been reported by many studies in Africa and Asia (18,21,(26)(27)(28).…”

Section: Discussionsupporting

confidence: 91%

Epidemiological profile of snakebites in Morocco

Arfaoui¹,

Hmimou²,

Ouammi³

et al. 2009

J. Venom. Anim. Toxins incl. Trop. Dis

View full text Add to dashboard Cite

ABSTRACT:The present work aims to find the epidemiological profile of snakebites in Morocco through a retrospective study of 1,423 snakebite cases that occurred between 1992 and 2007. Data were obtained from medical charts of envenomation at the Poison Control and Pharmacovigilance Center of Morocco. Results revealed that 86% of the snakebites had occurred in rural areas and that males were significantly more affected than females at a sex ratio of 23:20. Furthermore, 35% of the bites happened during the summer, with a peak of 215 cases in June (15.1%). We also discovered that 67.3% of the patients were bitten during the day. The age group that comprised the most agriculturally active persons, from 20 to 44 years old, was the most affected by snakebites (551 cases). In terms of evolution, patients who were at least 60 years of age (8.89%) as well as those who were less than 10 years old (7.50%) presented higher mortality. According to clinical severity grades, the data revealed a 70% predominance of grade 2 cases (430). Deaths had occurred only in patients with grades 3 and 4. Furthermore, grade 4 patients presented 100% mortality whereas grade 3 registered 10.7%. The distribution of snakebites according to administrative regions in Morocco showed a predominance of the Souss-Massa-Daraa region both in terms of frequency (32%) and mortality (72.1%). Our study clearly displayed the severity and extent of the snakebite problem in the country, thus revealing that public health authorities should give more attention to this serious situation.

show abstract

“…For the same reason, males were more afflicted with bites than females. Similar results have been reported by many studies in Africa and Asia (18,21,(26)(27)(28).…”

Section: Discussionsupporting

confidence: 91%

Epidemiological profile of snakebites in Morocco

Arfaoui¹,

Hmimou²,

Ouammi³

et al. 2009

J. Venom. Anim. Toxins incl. Trop. Dis

View full text Add to dashboard Cite

show abstract

“…14 The severity of a venomous bite is more dangerous than the antivenom if it remains untreated, while active management of venomous snakebites through proper guidelines should be practiced without fear. 15 Most of the cases that we came across during our study were of poisonous type 71.5%, which is almost similar to the result that was seen in the study done by Punde DP which showed 67.5% cases of poisonous type of snakebite. 16 Laboratory investigations like bleeding time and clotting time were done and also patient was assessed clinically for the type of snake bite prior to the administration of ASV.…”

Section: Discussionsupporting

confidence: 90%

A prospective observational study of drug usage in the management of snake bite patients and their outcome in a tertiary care teaching hospital

Hirebail

Nagabushan

Prakash

2017

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

Background: The objectives of the study were to assess the pattern of management of snakebite especially with respect to use of anti- snake venom and other supportive treatment given and to assess the effect of anti-snake venom on different types of snakebite and to assess their outcome.Methods: A prospective observational study was conducted over a period of 6 months, after getting approval from Institutional Ethics committee. Total of 144 snake bite patients were analysed for six months duration for use of anti-snake venom and other supportive treatment in their management and were assessed for their outcome like recovery, morbidity and mortality.Results: Out of 144 snake bite patients analysed, 71.5% had poisonous type and 28.4% had non- poisonous type of snake bite. Among the total number of snakebites, 47.2% were unknown type and among the known type 25% were viper, 13.2% cobra, 7.6% krait, 6.3% sea snake and 0.7% green snake. Anti-snake venom (ASV) was given to 62 patients depending on severity, of which, 22 patients developed reaction to ASV. Patient with reaction to ASV were treated with corticosteroid and antihistamine injection. Morbidity was seen in 29.1% of patients who developed either cellulitis or gangrene of bitten area, which was more commonly seen among viper bite patients (54.7%).Conclusions: Snakebite is one of the commonest tropical diseases leading to envenomation and poisoning especially in rural areas of tropical countries which has to be treated as early as possible to prevent complications. Majority of the cases in our study were of viper bite and most of them have recovered after treatment.

show abstract

“…7 The percentage of anti-snake venom reaction cases was much higher up to 88.57%, pyrogenic reaction was 80.64% and anaphylaxis was 64.51%. 8 Delayed reaction in the form serum sickness was not reported in our study. The criteria to define serum sickness were pre-defined as three or more of fever, erythematous rash, urticaria myalgia, arthralgia, headache, malaise, nausea and vomiting 5-20 days post-antivenom.…”

Section: Discussioncontrasting

confidence: 50%

“…Nearly 80% of anaphylactic reactions were due to urticaria. 8 All reactions had occurred within 30minutes of the commencement of ASV. Reactions had started as early as 4 minutes of starting ASV in this group.…”

Section: Discussionmentioning

confidence: 99%

Anti-snake venom induced reactions among children with snake envenomation

Varadarajan

Ravikumar

Jagadeeswari

et al. 2017

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: Snake envenomation in children is a neglected tropical condition with high morbidity and mortality. Life threatening neurotoxic and hemotoxic envenomation in children demands timely Anti Snake Venom (ASV) administration to improve the outcome.Methods: This was a prospective observational study undertaken at the pediatric intensive care unit of tertiary care referral center at Chengalpattu. All the 26 children with evidence of snake envenomation were recruited after informed consent of the caregivers during the study period. Clinical presentation and ASV related reactions were studied.Results: In this study of 26 children with envenomation, neurotoxic envenomation was more common. Foot was the common bite site. 10 of the 18 children (55.5%) had nocturnal bites. Ptosis, local swelling, hypotonia, headlag, vomiting and shock were the common clinical features. Polyvalent antivenom was used in all these children. ASV reactions of varying severity was encountered in 18 of the 26 children (69.2%). All the acute ASV reactions were encountered in the first 30 minutes. All the 18 children had rashes to begin with. Rashes and itching were the common feature of ASV reactions. Among children with reactions shock was seen in 50 %. Overall mortality was 3.85% (one child). None died due to anaphylaxis. The administration of ASV in primary and secondary centers was not carried out in time and the occurrence of anaphylaxis were not managed with inj adrenaline prior to referral. Inj pheniramine maleate, atropine and hydrocortisone were used by those centers. Referral after ASV reactions led to delay in completion of ASV administration.Conclusions: Occurence of ASV reactions is high in children (69%). There is an undue delay in ASV completion with ASV reactions. There is an urgent need for prevention of ASV reactions either by monovalent venoms or premedication prior to ASV administration.

show abstract

Anti-snake venom: use and adverse reaction in a snake bite study clinic in Bangladesh

Cited by 41 publications

References 13 publications

Epidemiological profile of snakebites in Morocco

Epidemiological profile of snakebites in Morocco

A prospective observational study of drug usage in the management of snake bite patients and their outcome in a tertiary care teaching hospital

Anti-snake venom induced reactions among children with snake envenomation

Contact Info

Product

Resources

About