Anti-SGPG antibody in CIDP: Nosological position of IgM anti-MAG/SGPG antibody-associated neuropathy

Spinal Nerve Root Hypertrophy on MRI: Clinical Significance in the Diagnosis of Chronic Inflammatory Demyelinating Polyradiculoneuropathy

“…We studied 14 MRI o f a c o n t r o l ( A, B ) a n d a r e p r e s e n t a t i v e c a s e ( c a s e 2 i n T a b l e 1 (9,22), and frequently produces conduction block (7,9). Total protein in CSF has been reported to show a significantly positive correlation with diameters of spinal nerve roots (10) …”

Asymmetrical and Isolated Hypoglossal Nerve Palsy Accompanied by a New Subset of Anti-ganglioside Antibodies in a Patient with Diffuse Large B Cell Lymphoma

“…In patients with autoimmune neuropathy, anti-ganglioside IgM antibodies are associated with chronic disease, including malignant lymphoma, through the mechanism of ‘binding site drift’, while anti-ganglioside IgG antibodies are associated with acute diseases, including Guillain-Barré syndrome, through the mechanism of ‘molecular mimicry’ (7). Some previously reported cases of autoimmune neuropathy in malignant lymphoma were associated with anti-ganglioside IgM antibodies, including anti-GM1, anti-GD1b, and anti-GQ1b IgM antibodies (1), while cases with M protein were accompanied by anti-SGPG IgM antibodies (8, 9). Anti-GM1 IgM antibodies are related to an asymmetrical neuropathy, while anti-GQ1b and anti-SGPG IgM antibodies are usually associated with polyneuropathy (8, 9); one exception exists in a reported case of asymmetrical facial nerve palsy in a patient who was positive for anti-SGPG IgM antibodies (10).…”

“…Some previously reported cases of autoimmune neuropathy in malignant lymphoma were associated with anti-ganglioside IgM antibodies, including anti-GM1, anti-GD1b, and anti-GQ1b IgM antibodies (1), while cases with M protein were accompanied by anti-SGPG IgM antibodies (8, 9). Anti-GM1 IgM antibodies are related to an asymmetrical neuropathy, while anti-GQ1b and anti-SGPG IgM antibodies are usually associated with polyneuropathy (8, 9); one exception exists in a reported case of asymmetrical facial nerve palsy in a patient who was positive for anti-SGPG IgM antibodies (10). Based on previous reports, the anti-GM1 and anti-SGPG IgM antibody positivity might have been associated with the asymmetrical and isolated hypoglossal nerve palsy in the present case.…”

An anti‐ganglioside antibody‐secreting hybridoma induces neuropathy in mice

“…FACS analysis was done on these cells after immunostaining. Sera also were collected from SCID mice implanted with anti‐MAG clone at the end of the experiment and tested for reactivity against sulfated glucuronyl paragloboside (SGPG) by ELISA according to previously described methods 47…”