Anti-secretory, anti-inflammatory and anti-Helicobacter pylori activities of several fractions isolated from Piper carpunya Ruiz &amp; Pav.

Quilez, Ana Maria; Berenguer, B.; Gilardoni, Gianluca; Souccar, Caden; Mendonça, Sérgio; Oliveira, Luís Flávio Souza de; Martín-Calero, M.J.; Vidari, Giovanni

doi:10.1016/j.jep.2010.01.060

Cited by 70 publications

(44 citation statements)

References 40 publications

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“…Cnidoscolus aconitifolius (F. Euphorbiaceae) es una planta fácil de cultivar con alta productividad en varias partes de la región suramericana y tiene un alto valor nutritivo (Ross-Ibarra & Molina-Cruz, 2002), por lo que es usada, comúnmente, tanto para propósitos medicinales como alimenticios (Escalante-Erosa, Ortegón-Campos, Parra-Tabla, & Peña-Rodríguez, 2004). Las hojas de Piper carpunya (F. Piperaceae) son ampliamente utilizadas en la medicina popular en los países tropicales y subtropicales de América del Sur como tratamiento de inflamaciones, úlceras y diarreas (Quílez et al, 2010). Parthenium hysterophorus (F. Asteraceae) ha mostrado efectos citotóxicos frente a A. salina (Al-Mamun, Hamid, Islam, & Chowdhury, 2010) y es usada para el tratamiento de llagas ulceradas, inflamaciones y enfermedades cardiovasculares (Madan, Gogia, & Sharma, 2011), diabetes (Patel, Chitra, Prassanna, & Krishnaraju, 2008), como antibacterial (Pandey, 2007) y también ha demostrado tener actividad antitumoral (Reddy et al, 2011).…”

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Concentraciones de alcaloides, glucósidos cianogénicos, polifenoles y saponinas en plantas medicinales seleccionadas en Ecuador y su relación con la toxicidad aguda contra Artemia salina

Jaramillo-Jaramillo

Jaramillo-Espinoza

D’Armas

et al. 2016

RBT

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Concentraciones de alcaloides, glucósidos cianogénicos, polifenolesy saponinas en plantas medicinales seleccionadas en Ecuador y su relación con la toxicidad aguda contra Artemia salina Alcoholic and aqueous extracts from leaves of these selected plants were prepared at different concentrations. To assess cytotoxicity of these extracts, different bioassays with A. salina were undertaken, and the mortality rates and LC 50 were obtained. Besides, concentrations of alkaloids, cyanogenic glycosides, phenols, tannins and saponins were determined by spectrophotometric methods; this constituted the first report of quantification of secondary metabolites in the selected plants from Ecuador. T. officinale had the highest concentration of total phenols (22.30 ± 0.23 mg/g) and tannins (11.70 ± 0.10 mg/g), C. aconitifolius of cyanogenic glycosides (5.02 ± 0.37 µg/g) and P. hysterophorus of saponins (6.12 ± 0.02 mg/g). Tannins values obtained were not adverse to their consumption. Alcoholic and aqueous extracts of selected plants had hemolytic activity depending on the concentration of saponins. Although the values of cyanogenic glycosides were permissible, it was necessary to monitor the presence of this metabolite in plants to minimize health problems. LC 50 values ranged from extremely toxic (3.37 µg/mL) to highly toxic (274.34 μg/mL), in P. carpunya and T. officinale, respectively. From correlation analysis, it was observed that increase values of alkaloids concentrations had highly significant (p<0.001) acute toxicity against A. salina, while at a higher polyphenol concentration the level of plants cytotoxicity decreased significantly (p<0.001). The results of principal component analysis showed that saponins apparently were in synergy with polyphenols to decrease cytotoxicity, but antagonize with alkaloids and cyanogenic glycosides, indicating that these secondary metabolites present variability in the mechanisms of action against A. salina, as cytotoxic compounds. These results also demonstrate that polyphenols and saponins can be lethal at low concentrations, demonstrating the potential of brine shrimp bioassay as a model to evaluate plant extracts containing low concentrations of chemical compounds with high polarities. The significant positive correlation between cytotoxicity and concentration of alkaloids confirmed by the bioassay of brine shrimp can be useful to identify promising sources of antitumor compounds, and to evaluate tolerable limits not affecting other benign cells. Contents of secondary metabolites found in the selected plants confer them great pharmacologic values. Rev. Biol. Trop. 64 (3):

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Concentraciones de alcaloides, glucósidos cianogénicos, polifenoles y saponinas en plantas medicinales seleccionadas en Ecuador y su relación con la toxicidad aguda contra Artemia salina

Jaramillo-Jaramillo

Jaramillo-Espinoza

D’Armas

et al. 2016

RBT

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“…Previous study suggested that the flavonoids (vitexin, isovitexin, rhamnopyranosylvitexin and isoembigenin), nervogenic acid and geranylbenzoate isolated from the ethanolic extract of Piper carpunya may contribute to the anti-myeloperoxidase activity, as well as to their anti-Helicobacter pylori effect. These flavonoids may also be responsible for the important inhibition of H+, K+-ATPase pathway, additionally the obtained phytosterols and phytol could be involved in these gastroprotective activities (Quilez et al, 2010).…”

Section: Flavonoids Isolated From Piper Carpunya Ruiz and Pavmentioning

confidence: 99%

Role of Natural Antioxidants in Gastritis

Elseweidy¹

2011

Gastritis and Gastric Cancer - New Insights in Gastroprotection, Diagnosis and Treatments

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“…They have long been the basis for usually used traditional medicines in some Asian countries [10]. Amid nutrients of citrus fruits, flavonoids have been more lately documented as having several benefits that contain antioxidant, antimicrobial, anti-inflammatory, and anti-cancer properties [11,12]. The flavonoids extracted from citrus fruit containing citrus aurantium L. are mostly consisted of hesperidin, naringenin, and nobiletin.…”

Section: Introductionmentioning

confidence: 99%

Cardio Protective Effects of Hydroalcholic Citrus Aurantium Extract on Myocardial Infarction Induced by Isoproterenol in Male Rats

2017

JCCR

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The citrus aurantium has traditionally been used by the people of Iran. The aim of this study was to evaluate the protective effects of hydroalcholic citrus aurantium extract on electrocardiographic, biochemical and pathological changes after myocardial infarction induced by isoproterenol in rats. 24 male Wistar rats were divided randomly into 4 groups: Control, extract, isoproterenol, and isoproterenol + pre-treatment with extract for two weeks. At the end of the experiment, ECG was recorded in lead II. Finally, blood samples were taken and cardiac marker enzymes such as creatine kinase, lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase, along with oxidative stress markers such as malondialdehyde, superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase, and lipid profile were determined.Myocardial infarction induced by isoproterenol produced a significant increase in the heart rate, ST-segment elevation, decrease in R amplitude, and a significant increase in the level of cardiac marker enzymes: LDH, CK-MB, AST, ALT and ALP in serum. Also, isoproterenol significantly reduced SOD, CAT, GSH, GP X and increased MDA activity, disturbance in lipid profile, and inflammatory process in cardiac myocytes. Pretreatment with citrus aurantium extract for two weeks significantly reduced the effect of isoproterenol on electrocardiographic parameters, cardiac biomarkers, oxidative stress indices, lipid profile and cardiac myocytes injuries.Results indicated that citrus aurantium extract ameliorates the cardio-toxic effects of isoproterenol through reinforcement of antioxidant defense system and may be of value in treatment of myocardial infarction. Further studies are required to determine the precise mechanism of the therapeutic effect of the extract.

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Anti-secretory, anti-inflammatory and anti-Helicobacter pylori activities of several fractions isolated from Piper carpunya Ruiz & Pav.

Cited by 70 publications

References 40 publications

Concentraciones de alcaloides, glucósidos cianogénicos, polifenoles y saponinas en plantas medicinales seleccionadas en Ecuador y su relación con la toxicidad aguda contra Artemia salina

Concentraciones de alcaloides, glucósidos cianogénicos, polifenoles y saponinas en plantas medicinales seleccionadas en Ecuador y su relación con la toxicidad aguda contra Artemia salina

Role of Natural Antioxidants in Gastritis

Cardio Protective Effects of Hydroalcholic Citrus Aurantium Extract on Myocardial Infarction Induced by Isoproterenol in Male Rats

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