Anti‐K formation is not associated with the storage time of transfused red blood cells

Abstract

Within the range of storage times used in normal clinical practice in the Netherlands, no association could be found between RBC storage time and anti-K formation.

Incidence of alloantibody formation after ABO‐D or extended matched red blood cell transfusions: a randomized trial (MATCH study)

“…In the study with the highest proportion of these specificities almost 30% of the patients had a transfusion history suggesting that an antigen booster is necessary to reach detectable antibody levels to these antigens . Regarding Rh and K antibodies, we observed that in the majority of responding patients, 1 to 2 incompatible units (RBCs or PLTs) were sufficient to induce antibodies, confirming the relative high immunogenicity of these antigens (D. Evers, R.A. Middelburg, S. Zalpuri, et al, submitted for publication) …”

“…7 Regarding Rh and K antibodies, we observed that in the majority of responding patients, 1 to 2 incompatible units (RBCs or PLTs) were sufficient to induce antibodies, confirming the relative high immunogenicity of these antigens (D. Evers, R.A. Middelburg, S. Zalpuri, et al, submitted for publication). 29 Residual non-D-matched RBC in PLT products have been reported to be the offender of anti-D in mainly immunosuppressed hematooncology patients, with reports of 0% to 14%, [30][31][32] while non-D antibodies have been scarcely reported. [33][34][35] In this study seven non-D antibodies (five anti-E, one anti-e and anti-K) were formed by six EM patients after cognate antigen exposure through (nonmatched) PLT transfusions.…”

The prevalence of anti‐K in Canadian prenatal patients

“…Use of K– units to prevent alloimmunization in young females would be an additional benefit of mass phenotyping programs. There has been interest in introducing further measures to prevent D alloimmunization, such as genotyping of D– donors to find D variants that may be missed on serologic typing . In countries such as Canada and the United States that have not implemented prophylactic measures to prevent K alloimmunization, a more effective way to further reduce HDFN may be to provide K‐matched units to female patients.…”

Mechanisms underlying red‐cell alloimmunization in sickle‐cell disease

“…A more recent study did not find also any relationship between anti-K formation and storage time of transfused red blood cells. [36]. In humans with SCD, Fasano et al [25] found no correlation between immunization and the age of the RBCs used for transfusion.…”

“…A more recent study did not find also any relationship between anti‐K formation and storage time of transfused red blood cells. . In humans with SCD, Fasano et al .…”