Anti-scorpion venom activity of Thapsia garganica methanolic extract: Histopathological and biochemical evidences

Bouimeja, Btissam; Hidan, Moulay Abdelmonaim El; Touloun, Oulaid; Laaradia, Mehdi Ait; Dra, Loubna Ait; Khoudri, Noureddine El; Chait, Abderrahman; Boumezzough, Ali

doi:10.1016/j.jep.2017.10.003

Cited by 10 publications

(2 citation statements)

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“…A similar observation of myocardial fiber’s focal fragmentation was detected in mice envenomed 3h with a LD 50 of B. occitanus venom. 41 Yet the animals treated with Androctonus australis hector scorpion venom presented the degeneration of myocardiocytes, accumulation of polymorphonuclear, granulocytes, macrophages and lymphocytes; associated with edema, acute hemorrhages and necrosis in the myocardium ventricle. 15…”

Section: Discussionmentioning

confidence: 99%

“…A similar observation of myocardial fiber's focal fragmentation was detected in mice envenomed 3h with a LD 50 of B. occitanus venom. 41 Yet the animals treated with Androctonus australis hector scorpion venom presented the degeneration of myocardiocytes, accumulation of polymorphonuclear, granulocytes, macrophages and lymphocytes; associated with edema, acute hemorrhages and necrosis in the myocardium ventricle. 15 The histological screening of the liver of envenomed by both venoms showed a sinusoidal dilation, a remarkable destruction of hepatocytes (caryolysis, psycnosis and necrosis) in addition to a congestion and turgescence in mice treated by the Bo and Am venoms, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Induced pathophysiological alterations by the venoms of the most dangerous Moroccan scorpions Androctonus mauretanicus and Buthus occitanus: A comparative pathophysiological and toxic-symptoms study

et al. 2022

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Scorpion envenomation is a serious public health issue. Androctonus mauretanicus ( Am) and Buthus occitanus ( Bo) are the most dangerous scorpions in Morocco. Despite their medical relevance, no study has yet related their kinetics of symptom apparition and the consequent tissue disorders at the same interval post-injection. This work achieved the first comparative pathophysiological and toxic-symptoms study between the Am and Bo venoms from a biochemical, toxicological and physiopathological standpoint. The activity of venoms and their subletal dose were determined by administration of increasing concentrations of the venoms. 30, 60 and 120 min following the experimental envenomation in mice, the profile of clinical symptoms was underlined and the main organs: brain, heart, lungs, liver and kidneys were removed for histological examination. The Am venom is a rich source of proteins and three-times more toxic than the Bo. The most observed clinical symptoms are neurological and cardiopulmonary. The Am venom caused histopathological alterations at 30, 60, and 120 min which were more important than the Bo. This study highlighted that both venoms exhibited a strong toxicity with variable intensities. Moreover, we showed the presence of correlation between the level of histopathological disorders observed and the intensity of signs appeared at the same time following venom inoculation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%