Anti-Saccharomyces cerevisiae IgG and IgA antibodies are associated with systemic inflammation and advanced disease in hidradenitis suppurativa

Assan, Florence; Gottlieb, J.; Tubach, Florence; Lebbah, Saïd; Guigue, Nicolas; Hickman, G.; Pape, E.; Madrange, Marine; Delaporte, E.; Sendid, Boualem; Aubin, F.; Derouin, Francis; Bretagne, Stéphane; Richette, Pascal; Smahi, Asma; Sbidian, É.; Bachelez, Hervé

doi:10.1016/j.jaci.2020.01.045

Cited by 38 publications

(31 citation statements)

References 9 publications

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“…were found to correlate to disease severity [89]. In addition, Saccharomyces cerevisiae yeast and one of its wall components, mannans, may also play a role in HS: anti-Saccharomyces cerevisiae antibodies (ASCAs) have been found in HS-serum and to be specifically present in comparison to psoriasis vulgaris and healthy controls,underlining its importance as a biomarker [90]. Assan et al even reported a significant elevation in the severe cases (Hurley III stage), suggestive for a prognostic marker for disease severity [90].…”

Section: Skin Microbiome In Hsmentioning

confidence: 99%

Gut–Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions

et al. 2021

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The microbiome plays an important role in a wide variety of skin disorders. Not only is the skin microbiome altered, but also surprisingly many skin diseases are accompanied by an altered gut microbiome. The microbiome is a key regulator for the immune system, as it aims to maintain homeostasis by communicating with tissues and organs in a bidirectional manner. Hence, dysbiosis in the skin and/or gut microbiome is associated with an altered immune response, promoting the development of skin diseases, such as atopic dermatitis, psoriasis, acne vulgaris, dandruff, and even skin cancer. Here, we focus on the associations between the microbiome, diet, metabolites, and immune responses in skin pathologies. This review describes an exhaustive list of common skin conditions with associated dysbiosis in the skin microbiome as well as the current body of evidence on gut microbiome dysbiosis, dietary links, and their interplay with skin conditions. An enhanced understanding of the local skin and gut microbiome including the underlying mechanisms is necessary to shed light on the microbial involvement in human skin diseases and to develop new therapeutic approaches.

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Section: Skin Microbiome In Hsmentioning

confidence: 99%

Gut–Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions

et al. 2021

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“…A range of efforts have been made to identify such biomarkers also beyond cytokines. 52,160,161 Conclusion HS is a complex, immunologically mediated disease that involves different components simultaneously: an inflammasome-driven innate component with dominance of neutrophilic granulocytes, a significant anti-inflammatory component, and strong activation of the Th1 and the Th17 pathways, but not the Th22 pathway. Anaerobic bacteria and cell-damage-associated molecules play an inflammation-triggering role.…”

Section: Role Of Specific Cytokines In Hidradenitis Suppurativamentioning

confidence: 99%

Aetiology and pathogenesis of hidradenitis suppurativa

2020

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Summary Hidradenitis suppurativa (HS) is a chronic inflammatory disorder. Patients develop inflamed nodules and abscesses and, at later stages of disease, epithelialized tunnels and scars in skinfolds of axillary, inguinal, gluteal and perianal areas. Quality of life is affected due to severe pain, purulent secretion, restricted mobility and systemic involvement. Genetics and lifestyle factors including smoking and obesity contribute to the development of HS. These factors lead to microbiome alteration, subclinical inflammation around the terminal hair follicles, and infundibular hyperkeratosis, resulting in plugging and rupture of the follicles. Cell‐damage‐associated molecules and propagating bacteria trigger inflammation and lead to massive immune cell infiltration that clinically manifests as inflamed nodules and abscesses. The immune system plays a key role also in the progression and chronification of skin alterations. Innate proinflammatory cytokines (e.g. interleukin‐1β and tumour necrosis factor‐α), mediators of activated T helper (Th)1 and Th17 cells (e.g. interleukin‐17 and interferon‐γ), and effector mechanisms of neutrophilic granulocytes, macrophages and plasma cells are involved. Simultaneously, skin lesions contain anti‐inflammatory mediators (e.g. interleukin‐10) and show limited activity of Th22 and regulatory T cells. The inflammatory vicious circle finally results in pain, purulence, tissue destruction and scarring. Chronic inflammation in patients with HS is also frequently detected in organs other than the skin, as indicated by their comorbidities. All these aspects represent a challenge for the development of therapeutic approaches, which are urgently needed for this debilitating disease. This scholarly review focuses on the causes and pathogenetic mechanisms of HS and the potential therapeutic value of this knowledge.

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“…HS patients have been shown to also have autoantibodies against citrullinated and extracellular matrix proteins 93 . Immunoglobulin producing plasma cells 95 and B cells 96 are major producers of IgD, IgG, IgM, ASCA and anti‐CCP antibodies 92,94,95 characterized in HS. The mechanisms of B‐cell‐mediated activation of other cells and potential pathogenicity are yet to be determined.…”

Section: Tissue T and B Cells In Hsmentioning

confidence: 99%