Anti-retinal autoantibodies in experimental ocular and systemic toxoplasmosis

Garweg, Justus G.; Kozak, Y. de; Goldenberg, Brigitte; Boehnke, Matthias

doi:10.1007/s00417-009-1242-z

Cited by 10 publications

(6 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This intravitreal injection in the rabbit model was also combined with a previous systemic infection to test the hypothesis of an autoimmune component in OT. However, their results did not indicate the stimulation of a reaction against retinal antigens by T. gondii presence in the eye (Garweg et al, 2009). More recently, intravitreal injection has been introduced in the mouse model (Lu et al, 2005;Charles et al, 2007).…”

Section: Modeling Physiopathology In Animalsmentioning

confidence: 92%

New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis

Pfaff

de-la-Torre

Rochet

et al. 2014

International Journal for Parasitology

View full text Add to dashboard Cite

Section: Modeling Physiopathology In Animalsmentioning

confidence: 92%

New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis

Pfaff

de-la-Torre

Rochet

et al. 2014

International Journal for Parasitology

View full text Add to dashboard Cite

“…The detection of ARAs in patients who ultimately had diagnoses of inherited retinal degeneration and posterior uveitis is not unexpected and has been previously reported. [22][23][24] There was some overlap in the molecular weights of the ARAs between the two groups and no discernable difference in the ARA patterns between the two groups. There were also patients in both groups who did not have detectable ARAs.…”

Section: Resultsmentioning

confidence: 94%

Correlation of Immunological Markers with Disease and Clinical Outcome Measures in Patients with Autoimmune Retinopathy

Stanwyck

Chan

Sood

et al. 2020

Trans. Vis. Sci. Tech.

View full text Add to dashboard Cite

To determine if immunological markers (1) are significantly different between autoimmune retinopathy (AIR) patients and controls and (2) correlate with disease progression in AIR patients. Methods: We enrolled patients with a possible AIR diagnosis, as well as control participants without eye disease, autoimmunity, or cancer. Immunological markers were tested in all participants. In addition, AIR patients had up to three blood draws for testing over their disease course. For AIR patients, clinical measures, including visual acuity (VA) and Goldmann visual field (GVF) area, were recorded at each draw. We used the Mann-Whitney U test to compare the immunological markers between AIR patients and controls. We used multilevel mixed-effect regression to investigate the correlation between markers and clinical parameters over time in AIR patients. Results: Seventeen patients with AIR and 14 controls were included. AIR patients had a higher percent of monocytes (Z = 3.076, P = 0.002). An increase in immunoglobulin G against recoverin was correlated with a VA decrease (β = 0.0044, P < 0.0001). An increase in monocyte proportion was correlated with a decrease in GVF area (β = −7.27, P = 0.0021). Several markers of B-cell depletion were correlated with GVF improvement. Conclusions: Monocytes may play a role in AIR pathophysiology and be a disease activity marker. B-cell depletion markers correlated with clinical parameter improvement, particularly GVF. Translational Relevance: This work elucidates immunologic markers that may improve the accuracy of diagnosis and treatment of AIR.

show abstract

“…The literature on autoreactivity against retinal components in the context of ocular toxoplasmosis encompasses the response against S-antigen (arrestin), rhodopsin, inter-photoreceptorbinding protein (IRBP) and extracts from human, bovine or primate retina (15)(16)(17)(18)(19)(20)(21)(22)(23). Attempts have been made to determine the association between clinical features in OT and the presence of anti-retinal autoantibodies.…”

Section: Discussionmentioning

confidence: 99%

“…Besides the damage caused by the parasite and the inflammatory response against it, an immune response triggered against autoantigens could be occurring and aggravating the clinical signs. In fact, several works related to OT and autoimmunity have been published, particularly on detection of antibodies or autoreactive lymphocytes using retinal extracts or isolated antigens -like rhodopsin or S antigen-in humans and rodent or lagomorph experimental models (15)(16)(17)(18)(19)(20)(21)(22)(23). Nevertheless, there is no consensus about the role of these responses as a cause or exacerbation of the eye disease; neither there is agreement on the mechanism of autoimmunity elicitation, i.e.…”

Section: Introductionmentioning

confidence: 99%

Autoantibodies Against Ubiquitous and Confined Antigens in Patients With Ocular, Neuro-Ophthalmic and Congenital Cerebral Toxoplasmosis

et al. 2021

View full text Add to dashboard Cite

Toxoplasma gondii infection can trigger autoreactivity by different mechanisms. In the case of ocular toxoplasmosis, disruption of the blood-retinal barrier may cause exposure of confined retinal antigens such as recoverin. Besides, cross-reactivity can be induced by molecular mimicry of parasite antigens like HSP70, which shares 76% identity with the human ortholog. Autoreactivity can be a determining factor of clinical manifestations in the eye and in the central nervous system. We performed a prospective observational study to determine the presence of autoantibodies against recoverin and HSP70 by indirect ELISA in the serum of 65 patients with ocular, neuro-ophthalmic and congenital cerebral toxoplasmosis. We found systemic autoantibodies against recoverin and HSP70 in 33.8% and 15.6% of individuals, respectively. The presence of autoantibodies in cases of OT may be related to the severity of clinical manifestations, while in cases with CNS involvement they may have a protective role. Unexpectedly, anti-recoverin antibodies were found in patients with cerebral involvement, without ocular toxoplasmosis; therefore, we analyzed and proved cross-reactivity between recoverin and a brain antigen, hippocalcin, so the immunological phenomenon occurring in one immune-privileged organ (e.g. the central nervous system) could affect the environment of another (egg. the eye).

show abstract

Anti-retinal autoantibodies in experimental ocular and systemic toxoplasmosis

Abstract: Our data afford no evidence of similarities between toxoplasmic and retinal antigens, nor of infection-induced humoral autoimmunity. They indicate rather that retinal autoantigens are liberated in the context of inflammatory tissue destruction due to ocular toxoplasmosis.

Cited by 10 publications

References 43 publications

New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis

New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis

Correlation of Immunological Markers with Disease and Clinical Outcome Measures in Patients with Autoimmune Retinopathy

Autoantibodies Against Ubiquitous and Confined Antigens in Patients With Ocular, Neuro-Ophthalmic and Congenital Cerebral Toxoplasmosis

Contact Info

Product

Resources

About