Anti-psychotics adherence among out-patients with schizophrenia in Hong Kong

Hui, Christy Lai Ming; Chen, Eric; Kan, C. S.; Yip, Ka Chee; Law, C.W.; Chiu, Chaw-Chi

doi:10.2302/kjm.55.9

Cited by 47 publications

(55 citation statements)

References 25 publications

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“…Among various factors such as long duration and serious adverse effects of medication and lack of social and family support [5,6], a lack of insight into the illness and medication taking is one of the most important inhibiting factors influencing medication adherence to antipsychotics and other treatments in patients with schizophrenia spectrum disorders [7]. In addition, acute and severe psychopathology (for example, suspicions and delusional beliefs), and any delay in seeking treatment during the early stages of schizophrenia, can render it difficult for prompt and efficacious interventions and understanding about the significance of medication adherence, thus reducing the likelihood of their adherence behaviors [6,8].…”

Section: Introductionmentioning

confidence: 99%

Effects of motivational interviewing-based adherence therapy for schizophrenia spectrum disorders: a randomized controlled trial

Chien

Mui

Cheung

et al. 2015

Trials

127

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BackgroundNon-adherence to antipsychotic medication is commonly found in schizophrenia and other psychotic disorders, thus forming a major obstacle to long-term maintenance treatment and contributing to high relapse rates. With limited evidence on the success of interventions in enhancing medication adherence, this controlled trial was designed to test and evaluate the effectiveness of an adherence therapy (AT) for outpatients with schizophrenia spectrum disorders, based on a motivational interviewing approach over a six-month follow-up period.MethodsA single-blind, randomized controlled trial with a repeated-measures, two parallel groups design was conducted in a random sample of 114 participants with schizophrenia spectrum disorders in one community psychiatric nursing service. After pre-test, the participants were randomly assigned to either an eight-session course of AT plus usual care or usual psychiatric care (n = 57 per group). The main outcomes, including medication adherence, symptom severity, insight into treatment, hospitalization rate, and functioning, were measured at baseline and immediately and six months post-intervention.ResultsA total of 110 participants completed this trial and thus the attrition rate was 3.5 %. Results of repeated-measures analysis of variance followed by Helmert’s contrasts test indicated that the AT participants reported significantly greater improvements in their insight into illness and/or treatment, psychosocial functioning, symptom severity, number of re-hospitalizations, and medication adherence (F = 5.01 to 7.45, P = 0.007 to 0.030) over six months follow-up, when compared with usual care.ConclusionsMotivational interviewing-based AT for people with schizophrenia can be effective to reduce symptom severity and re-hospitalizations, and improve medication adherence, functioning, and insight into illness and/or treatment over a medium term (six months) period of follow-up. Further study on the effects of AT in people with psychotic disorders in terms of diverse sociodemographic and illness characteristics, and a longer term (for example, over 12 months) follow-up period is recommended.Trial registrationThe trial was registered at Clinicaltrials.gov (identifier: NCT01780116) on 6 July 2014.

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Section: Introductionmentioning

confidence: 99%

Effects of motivational interviewing-based adherence therapy for schizophrenia spectrum disorders: a randomized controlled trial

Chien

Mui

Cheung

et al. 2015

Trials

127

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“…[28] This may be attributed to the distrust of young patients, in the first stages of disease, of the diagnosis and their need for treatment. However, other studies stated that older patients are at increased risk of non-adherence due to age related factors such as workingmemory loss and impaired executive performance, in addition to their administering multiple medications.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Risk Factors of Non-Adherence in Psychiatric Patients in Taif, Saudi Arabia

Alalyani¹

2017

WJPR

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Objectives: To estimate the prevalence of non-adherence to medication among and to explore the different reasons for drug non adherence among patient in mental health hospital in Taif city. Subjects and methods:It is a Cross-sectional descriptive study. The study included 255 patients who were following in Mental HealthHospital clinic. The total number was 255 patients, 233 patients were included in the study and 22 were excluded from the study according to eligibility criteria. The tool of the study was a self-administered questionnaire, which consists of three Parts: Demographic data, psychiatric diagnosis and reasons of not take the treatment. Result:Incidence of non-adherence was high (84.1%). The factors that increased the likelihood of non-adherence were absence of job, familial support and health education about medication use in addition to occurrence of side effects. Conclusion: The frequency of non-adherence is relatively high among the patients with psychiatric disorders in Taif city. Prevention strategies should focus on enhancing socioeconomic status (education and employment) and effective health education of patients to enable them to deal with adverse drug effects.

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“…13 regarding patient's age, younger patients show higher non-adherence rates than older ones. 50 Faith healers (9.61%), lack of family education (7.69%), were the most important psychosocial reasons for non-adherence to psychiatric medicines. 51 Compliance from the family members is also a dependent factor in non-adherence as has been revealed.…”

Section: Medication-related Factorsmentioning

confidence: 99%

Factors for Non - Compliance of Medication in Patients With Psychotic Illness

Kishore¹,

Manjeera²,

Gopalkrishnan³

et al. 2015

jemds

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Non-compliance is a significant problem in all patient population, from children to elderly. It is a serious problem and has many effects on overall treatment and prognosis of the illness. In spite of recent progress in the treatment of psychosis during the last decades, non-compliance continues to be a frequent phenomenon, often associated to potentially severe clinical consequences and high costs. The contributing factors of non-compliance in psychotic disorders can be divided in medication-related and patient-related. It is closely related to treatment outcome. This article is intended to review various factors related to non-compliance and relationship between them.

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Anti-psychotics adherence among out-patients with schizophrenia in Hong Kong

Cited by 47 publications

References 25 publications

Effects of motivational interviewing-based adherence therapy for schizophrenia spectrum disorders: a randomized controlled trial

Effects of motivational interviewing-based adherence therapy for schizophrenia spectrum disorders: a randomized controlled trial

Prevalence and Risk Factors of Non-Adherence in Psychiatric Patients in Taif, Saudi Arabia

Factors for Non - Compliance of Medication in Patients With Psychotic Illness

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