Anti-psoriatic effect of Lavandula angustifolia essential oil and its major components linalool and linalyl acetate

Bhatt

Chemistry & Biodiversity

et al. 2021

Self Cite

Artemisia pallens Wall. ex DC., popularly known as davana, has gained considerable attention because of its unique fragrance, high economic value, and pharmacological properties. The compositional complexity of davana essential oil (DO) has been a challenge for quality control. In this study, the chemical profile of DO was developed using polarity‐based fractionation and a combination of gas chromatographic (GC‐FID), hyphenated chromatographic (GC/MS), and spectroscopic (Fourier‐Transform Infra‐Red, 1D, 2D‐Nuclear Magnetic Resonance) techniques. The analysis led to the identification of ninety‐nine compounds. Major components of the DO were cis‐davanone (D3, 53.0 %), bicyclogermacrene (6.9 %), trans‐ethyl cinnamate (4.9 %), davana ether isomer (3.4 %), spathulenol (2.8 %), cis‐hydroxy davanone (2.4 %), and trans‐davanone (2.1 %). The study led to identifying several co‐eluting novel minor components, which could help determine the authenticity of DO. The rigorous column‐chromatography led to the isolation of five compounds. Among these, bicyclogermacrene, trans‐ethyl cinnamate, and spathulenol were isolated and characterized by spectroscopic methods for the first time from DO. Pharmacological profile revealed that the treatment of DO and D3 inhibited the production of pro‐inflammatory cytokines (TNF‐α, IL‐6) induced by lipopolysaccharide (LPS) in primary macrophages without any cytotoxic effect after administration of their effective concentrations. The result of this study indicates the suitability of DO and D3 for further investigation for the treatment of chronic skin inflammatory conditions.

Section: Resultssupporting

confidence: 91%

New Insights into the Chemical Composition, Pro‐Inflammatory Cytokine Inhibition Profile of Davana (Artemisia pallens Wall. ex DC.) Essential Oil and cis‐Davanone in Primary Macrophage Cells

Bhatt

Chemistry & Biodiversity

et al. 2021

Self Cite

“…Topical application of 100 μL 10% lavender oil for four days resulted in anti-psoriatic activity comparable with that of 100 μg 1% mometasone cream used as positive control. In addition, the inhibition of inflammatory markers such as TNF-α, IL-1β, -17 and -22 (Rai et al, 2020). However, the potential application of the plant extract of L. angustifolia in skin inflammatory conditions such as psoriasis is insufficiently explored.…”

Section: Introductionmentioning

confidence: 99%

Biotechnologically Produced Lavandula angustifolia Mill. Extract Rich in Rosmarinic Acid Resolves Psoriasis-Related Inflammation Through Janus Kinase/Signal Transducer and Activator of Transcription Signaling

et al. 2021

Psoriasis is a common skin pathology, characterized by dysregulation of epidermal keratinocyte function attended by persistent inflammation, suggesting that molecules with anti-inflammatory potential may be effective for its management. Rosmarinic acid (RA) is a natural bioactive molecule known to have an anti-inflammatory potential. Here we examined the effect of biotechnologically produced cell suspension extract of Lavandula angustifolia Mill (LV) high in RA content as treatment for psoriasis-associated inflammation in human keratinocytes. Regulatory genes from the nuclear factor kappa B (NF-κB) and Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathways were upregulated upon stimulation with a combination of interferon gamma (IFN-γ), interleukin (IL)-17A and IL-22. We also observed that both LV extract and RA could inhibit JAK2, leading to reduced STAT1 phosphorylation. Further, we demonstrated that LV extract inhibited phosphoinositide 3-kinases (PI3K) and protein kinase B (AKT), which could be implicated in reduced hyperproliferation in keratinocytes. Collectively, these findings indicate that the biotechnologically produced LV extract resolved psoriasis-like inflammation in human keratinocytes by interfering the JAK2/STAT1 signaling pathway and its effectiveness is due to its high content of RA (10%). Hence, both LV extract and pure RA possess the potential to be incorporated in formulations for topical application as therapeutic approach against psoriasis.

“…Caution should be exercised when using L. angustifolia oil as some irritative properties have been found. Topical treatments of L. angustifolia oil have been shown to be irritative to the skin of mice at 10% in polyethylene glycol 200 (Rai et al, 2020) and at 2.5 mg/ear (Cardia et al, 2018). Furthermore, L. angustifolia oil concentrations of 30 and 90 ug/mL have been shown to be cytotoxic, while lower concentrations were not (Cardia et al, 2018).…”

Section: Cytotoxicity and Irritative Propertiesmentioning

confidence: 99%

Spices and herbs as immune enhancers and anti-inflammatory agents: A review

Garnier¹,

Shahidi²

2021

JFB

Spices and herbs have been used in traditional medicine for centuries, with research starting to accumulate on their beneficial properties. Of these properties, the immune-enhancing and anti-inflammatory capabilities of many spices and herbs have led to promising results. The current review article aims to explore the current research of several spices and herbs as immune-enhancers and anti-inflammatory agents. The spices and herbs examined are African potato (Hypoxis hemerocallidea), allspice (Pimenta dioica), basil (Ocimum basilicum), black pepper (Piper nigrum), chili powders (Capsicum species), clove (Syzygium aromaticum), Devil’s claw (Harpagophytem procumbens), fenugreek (Trigonella foenum-graecum), ginger (Zingiber officinale), lavender (Lavandula angustifolia), oregano (Origanum vulgare), rooibos (Aspalathus linearis), rosemary/sage (Salvia rosmarinus/officinalis), saffron (Crocus sativus), South African geranium (Pelargonium sidoides), and turmeric (Curcuma longa). All the spices and herbs exhibited immune-enhancing or immunomodulatory and anti-inflammatory capabilities through various processes. Rooibos and oregano had the most contradictory results, with some studies finding pro-inflammatory properties, especially at high doses regarding oregano. Turmeric had the most extensive research with positive results.