Anti-pseudo-allergic components in licorice extract inhibit mast cell degranulation and calcium influx

Wang, Lu; Hu, Guizhou; Yin, Lu; Jiang, Shujun; Qi, Jin; Su, Hua

doi:10.1016/s1875-5364(22)60148-1

Cited by 3 publications

(6 citation statements)

References 25 publications

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“…Liquiritin, as a flavonoid, was reported to inhibit MRGPRX2-mediated PARs in our study for the first time. Previously, we discovered the inhibitory action of licorice extract against C48/80-triggered degranulation of MCs, and licochalcone A was screened to be a potential MRGPRX2 ligand by RBL-2H3 cell extraction [ 19 ], which is also consistent with a similar study on licochalcone A's anti-pseudo-allergy function [ 20 ]. In addition, isoliquiritigenin was also reported to possess anti-pseudo-allergy potential [ 21 ].…”

Section: Discussionsupporting

confidence: 78%

Liquiritin inhibits MRGPRX2-mediated pseudo-allergy through the PI3K/AKT and PLCγ signaling pathways

Wang

Huang²,

Li³

et al. 2023

Heliyon

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Section: Discussionsupporting

confidence: 78%

Liquiritin inhibits MRGPRX2-mediated pseudo-allergy through the PI3K/AKT and PLCγ signaling pathways

Wang

Huang²,

Li³

et al. 2023

Heliyon

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“…Exogenous ligands of MRGPRX2 include the cationic polymer compound 48/80 (C48/80), which is commonly used in receptor functional assays, and a variety of drugs approved by the Food and Drug Administration (FDA), such as fluoroquinolones (e.g., ciprofloxacin), neuromuscular blocking agents (e.g., rocuronium, atracurium), opioids (e.g., morphine), and many others [ 4 , 9 , 28 ]. MRGPRX2 can also be activated or inhibited by other exogenous agents, such as bacterial quorum sensing proteins, insect venoms [ 3 , 29 , 30 ], or many different plant xenobiotics ( Figure 1 ) [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 ]; representatives of which are described in the following part of this review.…”

Section: Pathophysiological Basismentioning

confidence: 99%

Section: Traditional Chinese Medicines and Plant-derived Compoundsmentioning

confidence: 99%

“…Licorice (synonyms: liquorice, and Gan-Cao in Chinese [ 139 ]) is scientifically known as the genus Glycyrrhiza [ 105 ] and is widely used in the food industry (as flavoring and sweetener agents [ 31 ]), in cosmetics and in pharmaceuticals [ 105 ]. At the same time, licorice is one of the most widely used ingredients in TCM [ 31 ]. It has many alleged biological effects, including protective activities against many types of cancer [ 105 ], antibacterial and anti-inflammatory effects [ 105 ].…”

Section: Traditional Chinese Medicines and Plant-derived Compoundsmentioning

confidence: 99%

“…It has many alleged biological effects, including protective activities against many types of cancer [ 105 ], antibacterial and anti-inflammatory effects [ 105 ]. Licorice extract contains a wide range of bioactive components, including flavonoids such as liquiritin, chalconoids (isoliquiritigenin and licochalcon A), and saponins (glycyrrhizic acid) ( Figure 1 ) [ 31 , 41 , 52 , 105 ]. Recent studies have proposed licorice ingredients as treatment agents for MRGPRX2-mediated anaphylactoid reactions [ 31 , 41 , 52 ].…”

Section: Traditional Chinese Medicines and Plant-derived Compoundsmentioning

confidence: 99%

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Modulation of the Mas-Related G Protein-Coupled Receptor X2 (MRGPRX2) by Xenobiotic Compounds and Its Relevance to Human Diseases

Dziadowiec,

Popiolek,

Kwitniewski

et al. 2024

JoX

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Mast cells (MCs) are immune cells that reside in tissues; particularly in the skin, and in the gastrointestinal and respiratory tracts. In recent years, there has been considerable interest in the Mas-Related G Protein-Coupled Receptor X2 (MRGPRX2), which is present on the surface of MCs and can be targeted by multiple exogenous and endogenous ligands. It is potentially implicated in non-IgE-mediated pseudoallergic reactions and inflammatory conditions such as asthma or atopic dermatitis. In this paper, we review natural products and herbal medicines that may potentially interact with MRGPRX2. They mainly belong to the classes of polyphenols, flavonoids, coumarins, and alkaloids. Representative compounds include rosmarinic acid, liquiritin from licorice extract, osthole, and sinomenine, respectively. While evidence-based medicine studies are still required, these compounds have shown diverse effects, such as antioxidant, analgesic, anti-inflammatory, or neuroprotective. However, despite potential beneficial effects, their use is also burdened with risks of fatal reactions such as anaphylaxis. The role of MRGPRX2 in these reactions is a subject of debate. This review explores the literature on xenobiotic compounds from herbal medicines that have been shown to act as MRGPRX2 ligands, and their potential clinical significance.

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Mast cell degranulation and bradykinin-induced angioedema - searching for the missing link

Porebski,

Dziadowiec,

Rybka

et al. 2024

Front. Immunol.

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Initiation of the bradykinin generation cascade is responsible for the occurrence of attacks in some types of angioedema without wheals. Hereditary angioedema due to C1 inhibitor deficiency (HAE-C1-INH) is one such clinical entity. In this paper, we explore the existing evidence that mast cells (MCs) degranulation may contribute to the activation of the kallikrein-kinin system cascade, followed by bradykinin formation and angioedema. We present the multidirectional effects of MC-derived heparin and other polyanions on the major components of the kinin-kallikrein system, particularly on the factor XII activation. Although, bradykinin- and histamine-mediated symptoms are distinct clinical phenomena, they share some common features, such as some similar triggers and a predilection to occur at sites where mast cells reside, namely the skin and mucous membranes. In addition, recent observations indicate a high incidence of hypersensitivity reactions associated with MC degranulation in the HAE-C1-INH patient population. However, not all of these can be explained by IgE-dependent mechanisms. Mast cell-related G protein-coupled receptor-X2 (MRGPRX2), which has recently attracted scientific interest, may be involved in the activation of MCs through a different pathway. Therefore, we reviewed MRGPRX2 ligands that HAE-C1-INH patients may be exposed to in their daily lives and that may affect MCs degranulation. We also discussed the known inter- and intra-individual variability in the course of HAE-C1-INH in relation to factors responsible for possible variability in the strength of the response to MRGPRX2 receptor stimulation. The above issues raise several questions for future research. It is not known to what extent a prophylactic or therapeutic intervention targeting the pathways of one mechanism (mast cell degranulation) may affect the other (bradykinin production), or whether the number of mast cells at a specific body site and their reactivity to triggers such as pressure, allergens or MRGPRX2 agonists may influence the occurrence of HAE-C1-INH attacks at that site.

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Anti-pseudo-allergic components in licorice extract inhibit mast cell degranulation and calcium influx

Cited by 3 publications

References 25 publications

Liquiritin inhibits MRGPRX2-mediated pseudo-allergy through the PI3K/AKT and PLCγ signaling pathways

Liquiritin inhibits MRGPRX2-mediated pseudo-allergy through the PI3K/AKT and PLCγ signaling pathways

Modulation of the Mas-Related G Protein-Coupled Receptor X2 (MRGPRX2) by Xenobiotic Compounds and Its Relevance to Human Diseases

Mast cell degranulation and bradykinin-induced angioedema - searching for the missing link

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